Clinical trials: Efavirenz
HIV, Infant Exposure to Efavirenz
Option B+: Study on Safety, Viral Suppression, and Survival on Second Line ART
To characterize safety, durability, antiretroviral treatment (ART) resistance, and clinical outcomes for mothers and infants exposed to the efavirenz-based Option B+ regimen for Prevention of Mother to Child Transmission (PMTCT)…
- Trial name
- S4 (NCT02249962)
- Where
- Malawi
- Volunteers
- 12,011 people
- Sponsor
- University of North Carolina, Chapel Hill
Pharmacokinetics, Efavirenz
Itraconazole Pharmacokinetic With and Without Efavirenz Using the Capsule Formulation as Part of Talaromycosis Treatment in HIV-infected Adults
Talaromycosis continues to be a common opportunistic fungal infection among people living with HIV/AIDS (PLWHA) in Southeast Asia and remains a leading cause of death among this population.
- Conditions
- Pharmacokinetics, Efavirenz, Penicilliosis
- Trial name
- ITRAPK (NCT04031053)
- Testing
- Pharmacokinetic study
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Chiang Mai University
Anti-Retroviral Agents, Efavirenz
Switching TDF/FTC/EFV to TDF/FTC/RPV VS Continuing TDF/FTC/EFV in HIV Patients With Complete Virological Suppression
According to the Thai National Guidelines for Treatment of HIV/AIDS 2014, the recommended first line ART regimen was 2 NRTIs backbone, TDF and FTC; plus 1 NNRTI, EFV, with RPV as an alternative one.
- Conditions
- Anti-Retroviral Agents, Efavirenz, HIV-1-infection, Sustained Virologic Response
- Trial name
- STEREOS (NCT03251690)
- Testing
- Tenofovir/Emtricitabine/Rilpivirine, Tenofovir/Emtricitabine/Efavirenz
- Volunteers
- 246 people
- Sponsor
- Mahidol University
Efavirenz, Child Behavior
Neuropsychiatric Side Effects of Efavirenz in Children Living With HIV
Efavirenz is among the preferred antiretroviral drugs for HIV-infected children. Increasing evidence shows that central nervous system side-effects in adults are more common than previously thought.
- Conditions
- Efavirenz, Child Behavior, Cognitive Symptom, Medication Adherence
- Trial name
- NCT03227653
- Testing
- Efavirenz, Nevirapine, Lopinavir-Ritonavir Drug Combination
- Where
- 6 sites in Tanzania
- Volunteers
- 144 people
- Sponsor
- Radboud University Medical Center
Cytochrome P-450 CYP2B6, Efavirenz
Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients
Genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) are associated with lower rate of EFV metabolism and lead to high exposure, as well as a higher risk of neuropsychiatric adverse event especially homozygous variant CYP2B6…
- Conditions
- Cytochrome P-450 CYP2B6, Efavirenz, HIV
- Trial name
- NCT02421289
- Testing
- Efavirenz, CYP450 2B6
- Where
- Thailand
- Volunteers
- 190 people
- Sponsor
- Mahidol University
Efavirenz, Metabolism and Pharmacokinetics Changes
Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy Volunteers
The purpose of this study is to see if administration of medicines and genetic differences affects the activity of a liver enzyme called CYP2B6 in healthy volunteers.
- Trial name
- NCT01104376
- Testing
- Efavirenz, voriconazole
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Indiana University