Clinical trials: Effect Increased
Intracranial Pressure Increase
Change of Optic Nerve Sheath Diameter After Deflation of Pneumatic Tourniquet
The purpose of this study is to evaluate the change of the optic nerve sheath diameter after deflation of pneumatic tourniquet.
- Trial name
- NCT03782077
- Testing
- Deflation of pneumatic tourniquet
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Lifestyle, Quality of Life
Long Term Effects of a Structured Lifestyle Program
The aim of the present study was to describe a structured intervention to reduce cardiovascular risk in a clinical setting and to study the effects of the program on lifestyle habits and quality of life in individuals at risk…
- Trial name
- NCT02744157
- Testing
- Longterm effects after a structured lifestyle program
- Volunteers
- 102 people
- Sponsor
- Karolinska University Hospital
Aging, Older Adults
Effects of an Exercise Program With Augmented Reality
The objectives of the present research is to observe the effects of a multimodal program with augmented reality on cognition, functional fitness, quality of life, and physical activity in older people.
- Trial name
- NCT05727748
- Testing
- Multimodal exercise with augmented reality, Multimodal exercise, Control group
- Where
- Portugal
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Évora
Smoking
Checking Smoking Status as a Routine Vital Sign: A Cluster-Randomized Trial of Its Effect on Cessation Counseling
The purpose of this study is to determine if checking smoking status as a routine vital sign increases the delivery rate of cessation counseling to adult smokers in primary care practices.
- Trial name
- NCT00245323
- Testing
- Smoking status as a routine vital sign
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Virginia Commonwealth University
Overweight, Obesity
Does Dairy Benefit Bone & Body Composition in Overweight Girls Undergoing a Weight Management Program?
The purpose of this study is to examine whether increased dairy intake, at the level recommended by Canada's Food Guide, combined with healthy eating and exercise, will improve body composition and bone turnover over 12 weeks in…
- Conditions
- Overweight, Obesity, Children
- Trial name
- NCT02581813
- Testing
- I.D.E.A.L. for Adolescents Study - Higher Dairy, I.D.E.A.L. for Adolescents Study - Lower Dairy
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Brock University
Multiple Sclerosis
Sunphenon in Progressive Forms of Multiple Sclerosis
The investigators hypothesize that an oral Sunphenon EGCg (Epigallocatechin-Gallat, EGCG) treatment is - due to its antiinflamatoric and neuroprotective potence - significantly more effective than an oral placebo treatment…
- Trial name
- SUPREMES (NCT00799890)
- Testing
- Sunphenon EGCG
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Friedemann Paul
Alveolar Recruitment Manoeuver, Anesthesia
Effect Alveolar Recruitment Manoeuver on Stroke Volume a Randomized Study
Objective: to compare the effect of alveolar recruitment manouver through stepwise increase and decrease in airway pressure or sustained 30 secondes 30 cmH2O continuous positive airway pressure on cardiac stroke volume estimated…
- Trial name
- hemorecrut-2 (NCT04802421)
- Testing
- alveolar recruitment manoeuver
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Lateral Ankle Instability, Chronic Lateral Ankle Instability
Brostrom Chronic Lateral Ankle Instability Repairs Augmented With BioBrace®
The purpose of this investigation is to evaluate pre- and post-operative patient reported outcomes and functional scores after open non-augmented Broström repair or open Broström repair augmented with the BioBrace Implant.
- Conditions
- Lateral Ankle Instability, Chronic Lateral Ankle Instability, Brostrom Procedure, ATFL
- Trial name
- NCT07708584
- Testing
- Standard Brostrom Repair, Brostrom repair with augmentation
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Osteopenia
The Effect of Semaglutide on Bone Turnover in Patients With Increased Risk of Bone Fracture
The hypothesis for this study is that the GLP-1Ra Semaglutide has a positive effect on the balance between build-up and degradation as well as the strength of the bones in men and women aged 40-85 years at increased risk of bone…
- Trial name
- NCT04702516
- Testing
- Ozempic
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Morten Frost
Transfusion Adverse Reaction, Major Trauma
Blood Storage Related Mortality and Adverse Effects in Trauma Patients
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1.
- Conditions
- Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
- Trial name
- NCT07341139
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Intensive Care Unit Acquired Paresis, Muscle Wasting
Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP)
The primary hypothesis for this study is that Myostatin and FHL-1 are important in the development of ICUAP and that changes in activity levels of muscle will modify the levels of expression and activity of these proteins.
- Trial name
- NCT01321320
- Testing
- Active muscle stimulation
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
GLUT1 Deficiency Syndrome, GLUT1DS1
Sodium Lactate Infusion in GLUT1DS Patients
This study investigates the effect of lactate infusion on epileptic discharges on EEG and seizure frequency in glucose transporter 1 deficiency syndrome (GLUT1DS) patients.
- Conditions
- GLUT1 Deficiency Syndrome, GLUT1DS1, GLUT1DS2, Epilepsy
- Trial name
- NCT04112862
- Testing
- sodiumlactate
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- Radboud University Medical Center
Acute Respiratory Failure
Effect of Increased Muscular Work During Different Weaning Strategies in Critically Ill Patients
Most patients admitted to intensive care units require mechanical ventilation. Weaning from assisted/controlled ventilation begins when we recognize that the patient has recovered adeguately from acute respiratory failure.
- Trial name
- NCT00538746
- Testing
- BIPAP, PSV, PSV + CPAP
- Where
- Italy
- Sponsor
- Università degli Studi dell'Insubria
Energy Expenditure, Obesity
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
Our body fat (adipose tissue) is largely made up of white adipose tissue (WAT) that stores surplus energy as white fat depots. In addition, adult humans have another type of fat similar to the brown fat in babies that burns up…
- Conditions
- Energy Expenditure, Obesity, Brown Adipose Tissue
- Trial name
- NCT04595006
- Testing
- Cold Stimulation (CS), Browning Nutraceutical (BN), Cold Stimulation and Browning Nutraceutical (CSBN)
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Acute Kidney Injury
Patients Undergoing Continuous Venovenous Hemodiafiltration: Effects of Increased Blood Flow
Acute Kidney Injure (AKI) is a syndrome with high incidence and prevalence in Intensive Care Units (ICU). It is estimated that 50% of the in the sector present AKI at some point and 10 to 15% require renal replacement therapy…
- Trial name
- NCT05796661
- Testing
- Effects of increased blood flow during regional anticoagulation with 4% trisodium citrate in patients undergoing continuous venovenous hemodiafiltration
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Hospital Israelita Albert Einstein
Cirrhosis, Portal Hypertension
Effects of Dark vs. White Chocolate on the Postprandial Increase in Portal Pressure in Cirrhosis
This study was aimed at testing the hypothesis that supplementing a meal with dark chocolate, which holds potent antioxidant properties, might attenuate the postprandial increase in the hepatic venous pressure gradient (HVPG…
- Trial name
- NCT01408966
- Testing
- DarkChocolate, WhiteChocolate
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Hospital Clinic of Barcelona
Stroke Volume Variation, Arterial Pressure
Comparison of Hemodynamic Effect of 2 Methods for Alveolar Recruitment Maneuver in Anesthetized Patients
During general anaesthesia, pulmonary atelectasis has been shown to occur in 85 to 90% of patient. Pulmonary atelectasis increases occurrence of postoperative pulmonary complication including pneumoniae.
- Trial name
- Hemorecrut (NCT03215329)
- Testing
- abdominal or vascular surgery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Asthma
Behavioral Intervention to Increase Physical Activity in Patients With Asthma
The health benefits of physical activity (PA) are well documented and include improving in cardiovascular, obesity, mental health and all-cause mortality.
- Trial name
- NCT03705702
- Testing
- Education Program, Behavioral intervention
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Infection, Human Immunodeficiency Virus
A Study to Assess the Effect of High Fat Meal and Increased Gastric pH on the Bioavailability of an Extended Release Formulation of BMS-663068 in Healthy Subjects
The purpose of this study is to estimate the effect of high fat meal and increased gastric pH on BMS-663068 bioavailability
- Trial name
- NCT02666053
- Testing
- BMS-663068
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare