Clinical trials: Effect Neonatal
Sickle Cell Anemia
Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia
A total of fifty severely affected patients with homozygous sickle cell disease or other sickling disorders (e.g. B negative or B positive Thalassemia/Sickle) who are greater than 18 years of age will be eligible for treatment.
- Trial name
- NCT00001197
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Reiki, Colic, Infantile
The Effects of Reiki Therapy in Infants With Colic
This double-blind, randomized controlled experimental study aims to determine the effect of Reiki therapy administered to infants with infantile colic (aged 3 weeks to 6 months) on infants' colic symptoms and crying duration, as…
- Trial name
- NCT07254520
- Testing
- Reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- University of Yalova
Tourette Syndrome
Dopaminergic Effects on Cortical Function in Tourette's (Levodopa Protocol)
Dr. Kevin J. Black at Washington University is conducting a study to learn whether we can use MRI scans to test dopamine function in the brain and to determine whether the brain performs memory tasks differently in Tourette…
- Trial name
- TSfMRI (NCT00634556)
- Testing
- levodopa solution 2mg/ml for i.v. use
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Preterm Neonates Pain Managment, PreTerm Neonate
Pain Managment in Preterm Neonates
To compare the effect of Intranasal versus Intravenous Fentanyl on oxidative stress by measuring MDA level just before and after 30 minutes from painful procedure and comparing the results.
- Trial name
- NCT07148882
- Testing
- fentanyl
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Atopic Dermatitis
Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE)
This is a multicenter, randomized, double-blind, placebo-controlled study to be conducted in the United States in subjects with atopic dermatitis.
- Trial name
- NCT03568331
- Testing
- Tradipitant
- Where
- 70 sites in United States
- Volunteers
- 375 people
- Sponsor
- Vanda Pharmaceuticals
Cystic Fibrosis
Clinical Effects of Exercise Program Added to Pulmonary Rehabilitation in Patients With Cystic Fibrosis
The aim of this study is to investigate the effects of postural exercise program added to pulmonary rehabilitation program on quality of life, exercise tolerance and postural stability in children with Cystic Fibrosis.
- Trial name
- NCT03295201
- Testing
- Active cycle of breathing techniques (ACBT), Postural Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Marmara University
Spinal Muscular Atrophy, SMA
SPACE Trial: Pyridostigmine vs Placebo in SMA Types 2, 3 and 4
A trial investigating the effects of pyridostigmine (mestinon) versus a placebo in a double-blind cross over trial in patients with hereditary proximal spinal muscular atrophy (SMA) types 2, 3 and 4.
- Conditions
- Spinal Muscular Atrophy, SMA, Kugelberg-Welander Disease
- Trial name
- SPACE (NCT02941328)
- Testing
- Pyridostigmine
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- UMC Utrecht
Infection, Neonatal
Intervention Study to Improve Maternal Handwashing
The purpose of the handwashing intervention trial is to determine whether an interactive, storytelling approach to promoting handwashing with soap by health care workers can improve mothers' handwashing behavior during the first…
- Trial name
- NCT02764528
- Testing
- Clinic, Clinic + home, Clinic + home + handwashing device
- Where
- Kenya
- Sponsor
- State University of New York at Buffalo
Induced Vaginal Delivery
Newborn Pain and Stress Levels in Oxytocin Induction at Birth
The aim of the study is to compare pain and stress levels in the early neonatal period in newborns with and without oxytocin induction. The research was conducted in a case-control study design.
- Trial name
- NCT06474000
- Testing
- Oxytocin induction group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Hemolytic Disease of the Newborn, Fetal Anemia
Neonatal Outcomes on Direct Fetal Intravenous Immunoglobulin During Intrauterine Transfusion for Rhesus Isoimmunization
The goal of this clinical trial is to learn if giving intravenous immunoglobulin directly to the fetus during intrauterine transfusion can improve newborn outcomes in pregnancies affected by rhesus isoimmunization.
- Conditions
- Hemolytic Disease of the Newborn, Fetal Anemia, Rhesus Isoimmunization, Erythroblastosis Fetalis Due to RH Antibodies
- Trial name
- NCT07885592
- Testing
- Intrauterine Transfusion, Intravenous immunoglobulin (IVIG)
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pes Planus
Effects of Custom-Designed 3D-Printed and CAD-CAM Insoles on Individuals With Flexible Flatfoot
This study aims to investigate the effects of custom-designed insoles produced using Computer Numerical Control (CNC) and 3D printers on plantar pressure distribution analysis, foot posture, plantar force distribution, foot pain…
- Trial name
- Insoles (NCT07022093)
- Testing
- Custom made insoles
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- GÖZDE KESİKBAŞ
Pain, Analgesia
EUROpean Pain Audit In Neonates
EUROPAIN Survey is an epidemiological study aimed at assessing current clinical practices regarding the use of sedative and analgesic drugs in newborns admitted to NICUs or PICUs in different countries in Europe.
- Conditions
- Pain, Analgesia, Sedation, Intesive Care
- Trial name
- EUROPAINsurvey (NCT01694745)
- Where
- 242 sites in Austria, Belgium and 16 more
- Volunteers
- 6,489 people
- Sponsor
- Hôpital Armand Trousseau
Primary Ciliary Dyskinesia
The Effect of a Dietary Supplement Rich in Nitric Oxide in Patients Diagnosed With Primary Ciliary Dyskinesia.
The purpose of this study is to determine the effect of a dietary supplement rich in nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on ciliary beat frequency assessed by high-speed digital…
- Trial name
- NCT04489472
- Testing
- Beet-it Juice
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
ADPKD, Glomerulonephritis
Effects of Systemic NO-Inhibition on Renal Hemodynamics in Patiens With Polycystic Kidney Disease and Chronic Glomerulonephritis
The study tests the hypothesis that systemic and renal nitric oxide availability is changed in polycystic kidney disease and chronic glomerulonephritis.
- Trial name
- NCT00345137
- Testing
- Ng-monomethyl-L-arginine (drug)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
Patients with diabetes have high blood sugar levels (hyperglycemia) because pancreatic beta-cells no longer produce sufficient insulin.
- Trial name
- NCT00813228
- Testing
- Sitagliptin (Januvia)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non Synostotic Plagiocephaly
Effect of Usage Time of Helmet in Babies With Deformational Plagiocephaly
Investigating the optimal usage time of helmet therapy is the aim of the study. Participants will be babies with deformational plagiocephaly. Plagiocephalometric assesments will be utilize to follow improvement of head symmetry.
- Trial name
- NCT03430739
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Hacettepe University
Pes Planus
Effect of Different Exercise Approaches on Balance and Proprioception in Individuals With Pes Planus
Pes planus; It can be defined as the valgus of the hindfoot while loading the foot, the disappearance of the medial longitudinal arch in the midfoot, and the supination of the forefoot relative to the hindfoot.
- Trial name
- NCT05549063
- Testing
- Mobility and Stability Exercise, Stretching Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Choledochal Cyst
A Longitudinal Cohort Study on the Changes of Physiological Mechanisms in Children After Biliary Tract Reconstruction
Through observational studies, the long-term changes in liver function, metabolic state, immune response and other aspects of children after biliary tract reconstruction during their growth process were systematically explored.
- Trial name
- NCT07530354
- Where
- 3 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wuhan Children's Hospital
White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting
The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot…
- Conditions
- White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Enamel Hypomineralization
- Trial name
- RI (NCT06696105)
- Testing
- Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Acute Chest Syndrome
Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin
The study evaluates the effect of platelet inhibition and / or lipid lowering in non-ACS-patients with symptoms suggestive for ACS, and elevated high-sensitivity troponin values
- Trial name
- GRAY-ZONE (NCT03820466)
- Testing
- Aspirin, Atorvastatin
- Where
- 7 sites in Germany
- Volunteers
- 68 people
- Sponsor
- Dr. med. Mahir Karakas
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