Clinical trials: Effect of Drug
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Hand-Foot Syndrome
The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot Syndrome
Chemotherapy or target therapy-induced hand-foot syndrome in cancer patients affects the quality of life. At present, there is no better treatment for this side effect of chemotherapy or target therapy.
- Trial name
- NCT05949307
- Testing
- acupuncture, laser acupuncture
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
The Main Focus of This Study is to Evaluate the Safety of Zingiber Officinale L. Tablets as Hypolipidemic Agent in Hypertensive Patients
Protective Effect of Zingiber Officinale L. Extract in Hypertensive Patients
Hyperlipidemia is a well-known risk factor for cardiovascular diseases (CVDs). Coronary heart disease, stroke, and atherosclerosis are among the primary cause of death.
- Trial name
- NCT05682911
- Testing
- Zingiber officinale L. tablets, Simvastatin 20mg
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Jinnah Sindh Medical University
Nausea
Bioavailability Study of Anti Nausea Medication With and Without Food (EUR-1025)
This study is to assess the effect of food on a single dose of Ondansetron when taken with a meal on an empty stomach.
- Trial name
- ODO-P8-689 (NCT00981487)
- Testing
- Ondansetron
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Tricuspid Regurgitation, Tricuspid Valve Disease
Investigation of a Transcatheter Tricuspid Valved Stent Graft in Patients With Carcinoid Heart Disease
The purpose of this investigation is to see if the TRICENTO Valved Stent Graft implant reduces tricuspid regurgitation (TR) and improves the symptoms and quality of life in 15 participants with carcinoid heart disease, and who…
- Conditions
- Tricuspid Regurgitation, Tricuspid Valve Disease, Carcinoid Syndrome, Carcinoid Heart Disease
- Trial name
- TRICAR (NCT05064514)
- Testing
- Transcatheter Tricuspid Valved Stent Graft
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen Mary University of London
Small Cell Lung Carcinoma
Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain
This phase I/II trial studies the effects and safety of giving lithium carbonate (lithium) to patients with small cell lung cancer (SCLC) undergoing radiation therapy to the brain (PCI; prophylactic cranial irradiation).
- Trial name
- NCT01553916
- Testing
- Lithium Carbonate, Prophylactic cranial irradiation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Washington University School of Medicine
Anesthesia
Hypnoanalgesia for Dermatological Surgery in Children
This randomized clinical trial will evaluate the effect of hypnosedation on the need of sedation and analgesia in a pediatric population undergoing dermatological surgery, both during the procedure, and 24 hours after surgery.
- Trial name
- NCT04707014
- Testing
- Hypnosis, Attention-distracting techniques
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Complejo Hospitalario de Toledo
Healthy Participants
A Study of Experimental Medication BMS-986278 Given to Healthy Participants
The purpose of this study is to investigate experimental medication BMS-986278 given to healthy participants.
- Trial name
- NCT03429933
- Testing
- BMS-986278
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Drug Compliance
The Effect of Motivational Interviewing on the Adherence to Medication of Patients With COVID-19 Diagnosed at Home
Summary Objective: The aim of this study is to determine the effect of health education supported by motivational interviewing on drug therapy compliance of patients with COVID-19 who are followed at home.
- Trial name
- MOTIVATION (NCT05676021)
- Testing
- motivational interview
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Anaemia
Single Dose, Pharmacokinetic, Safety, Tolerability and QTc Study of GSK1278863 in Healthy Volunteers
This study is being performed to comply with regulatory requirements that all new non-antiarrhythmic drugs must be assessed for potential effects on cardiac repolarization through electrocardiographic evaluation in a 'Thorough…
- Trial name
- NCT02293148
- Testing
- GSK1278863 75 mg, GSK1278863 500 mg, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Tardive Dyskinesia, Antipsychotic Agents
Randomized Controlled Trial of Pyridoxine for Tardive Dyskinesia
Purpose: Tardive dyskinesia (TD) is a involuntary movement disorder that can occur following long term treatment with antipsychotic medications and for which few treatment options exist.
- Trial name
- NCT03287778
- Testing
- Pyridoxine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
DDI (Drug-Drug Interaction)
Drug-Drug Interaction Study of Befotertinib Capsules in Healthy Participants.
This study adopts a single-center, open-label, same-subject sequential crossover clinical trial design, aiming to evaluate the effects of oral administration of rifampicin or itraconazole on the pharmacokinetic profiles of…
- Trial name
- NCT07809815
- Testing
- Befotertinib and rifampicin, Befotertinib and itraconazole
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Healthy Volunteers
Safety and Immunological Effects of Two Mistletoe Preparations in Healthy Volunteers
The objective of this clinical trial is to describe safety, tolerability and the course of parameters of the immune system during administration of different doses of two subcutaneously administered mistletoe preparations…
- Trial name
- NCT01378702
- Testing
- mistletoe preparations
- Where
- Germany
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Liver Cirrhosis
Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial
Proton-pump inhibitors (PPI) are commonly prescribed in an uncritical manner to patients with liver cirrhosis without a clear evidence-based indication.
- Trial name
- STOPPIT (NCT04448028)
- Testing
- Esomeprazole 20mg
- Where
- Germany
- Volunteers
- 476 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mesenchymal Stromal Cells, Psoriasis
Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment in Patients With Moderate to Severe Psoriasis
The purpose of this study is to evaluate the efficacy and safety of Adipose derived Mesenchymal Stem Cells (AD-MSCs) plus Calpocitriol Ointment with moderate to severe psoriasis.
- Conditions
- Mesenchymal Stromal Cells, Psoriasis, Drug Effect, Drug Toxicity
- Trial name
- NCT03392311
- Testing
- Calcipotriol ointment, adipose-derived multipotent mesenchymal stem cells
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Healthy
Drug-drug Interaction Between Digoxin, Furosemide, Metformin, and Rosuvastatin
To investigate the mutual interaction potential of digoxin, furosemide, metformin, and rosuvastatin when given alone or together as a cocktail, and to investigate the effect of high doses of metformin or furosemide on…
- Trial name
- NCT02231931
- Testing
- Digoxin, Rosuvastatin, Digoxin, Furosemide, Metformin hydrochloride, Rosuvastatin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Breastfeeding Self-Efficacy, Postpartum Women
Digital Storytelling and Breastfeeding Education
The aim of this study was to evaluate the effect of breastfeeding education provided using the digital storytelling method on mothers' breastfeeding self-efficacy and breastfeeding success.
- Conditions
- Breastfeeding Self-Efficacy, Postpartum Women, Health Education, Breastfeeding
- Trial name
- NCT07657819
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Zübeyde Ceylan
Cognition, Affect (Mental Function)
BiomeBakery Project
This study aims to investigate the chronic effects of prebiotic fibre-fortified functional bakery product on cognitive, affective, inflammatory, metabolic, and anthropometric outcomes in healthy adults aged 60-75 years with mild…
- Conditions
- Cognition, Affect (Mental Function), C Reactive Protein
- Trial name
- NCT06796712
- Testing
- Prebiotic fibre fortified bread roll, Regular bread roll
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Reading
Menopause
Qing'E Formula Therapy on Menopausal Symptoms
The objective of this study is to evaluate whether a Chinese medicine formula (Qing'E) is effective in alleviating menopausal symptoms and safety.
- Trial name
- NCT01805765
- Testing
- Qing'E pills
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine