Clinical trials: Effect of Drugs
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Schizophrenia
Novel Candidate Genes for Treatment Response to Antipsychotics in Schizophrenia
Schizophrenia is a severe and chronic mental disorder. The lifetime risk of schizophrenia is around 1%. Its course is chronic and frequently disabling. The keystone of schizophrenia treatment is antipsychotic medications.
- Trial name
- GEXANT (NCT02205437)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Cannabis, Drug Effect
The Pharmacokinetics and Pharmacodynamics of Hemp-based Topical Cannabinoid Products
This study will evaluate the pharmacokinetic and pharmacodynamic effects of hemp-based Cannabidiol (CBD) topical products (e.g., lotions, creams, patches) that contain low levels of delta-9-tetrahydrocannabinol (THC).
- Trial name
- NCT04741477
- Testing
- CBD, THC
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Angina
Effect of Febuxostat Compared to Placebo on Exercise Tolerance in Participants With Chronic Stable Angina
The purpose of this study is to evaluate the effect of febuxostat, once daily (QD), compared to placebo as an add on to stable anti-anginal therapy, on the total exercise time of participants with Chronic Stable Angina.
- Trial name
- NCT01549977
- Testing
- Febuxostat
- Where
- 21 sites in United States
- Volunteers
- 1 people
- Sponsor
- Takeda
Hypertriglyceridemia, HIV Infections
Effect of Soluble Fiber on Hypertriglyceridemia and Immune Profile in HIV-positive Individuals.
The purpose of this study was to assess the effect of soluble fiber® (partially hydrolyzed guar gum) supplementation on hypertriglyceridemia and immune profile in HIV-positive individuals on HAART.
- Trial name
- NCT00540111
- Testing
- soluble fiber® (partially hydrolyzed guar gum)
- Volunteers
- 19 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Platelet Aggregation, ADP Blockers
Aggreguide A-100 ADP Assay Evaluation
The study is to characterize the AggreGuide ADP Assay's performance.
- Trial name
- NCT02112539
- Testing
- platelet aggregation measurement
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Aggredyne, Inc.
Malaria
Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir
The purpose of this study is to assess the effect of multiple doses of ganaplacide and lumefantrine combination on the substrates of cytochrome P450 (CYP) 3A4 (midazolam), CYP2C8 (repaglinide), CYP2D6 (dextromethorphan), organic…
- Trial name
- NCT05236530
- Testing
- Midazolam, Repaglinide, Dextromethorphan
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy
Drug Interaction Study of ASC42 With Atorvastatin
The purpose of this study is to determine whether ASC42 alters the pharmacokinetics of atorvastatin in healthy subjects.
- Trial name
- NCT05464628
- Testing
- Atorvastatin, ASC42
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Gannex Pharma Co., Ltd.
Healthy
A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participants
The main purpose of this study is to assess the effect of carbamazepine on the amount of orforglipron in the bloodstream and how long it takes the body to get rid of orforglipron when given orally in healthy study participants.
- Trial name
- NCT06370728
- Testing
- Orforglipron, Carbamazepine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hypertansion
Generative AI-Supported Personalized Education Compared With Printed Material for Adults With Hypertension
This study evaluates whether generative artificial intelligence-supported personalized education can improve hypertension knowledge and medication adherence in adults with hypertension compared with standard printed educational…
- Trial name
- GenAI-HYPER (NCT07776834)
- Testing
- Standard Hypertension Education, Generative AI-Supported Personalized Hypertension Education
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Akdeniz University
Allergy, Allergy;Food
Allergy Diagnostic Test Based on Microchip Technology
The purpose of this study is to develop a microarray-based diagnostic test system for the determination of allergen specific IgE in human blood serum.
- Conditions
- Allergy, Allergy;Food, Allergy Pollen, Allergy Drug
- Trial name
- NCT06167564
- Testing
- Routine allergy tests, Newly developed microarray-based diagnostic test system
- Where
- Belarus
- Volunteers
- 400 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Alexithymia, Empathy Skills
Film-Based Medical Education and Social Justice Course: Effects on Alexithymia and Empathy in Medical Students
This study will examine whether a 14-week elective course that uses films and guided discussion on social justice in health care can improve medical students' empathy skills and reduce alexithymia (difficulty recognizing and…
- Conditions
- Alexithymia, Empathy Skills, Education, Medical, Social Justice Advocacy
- Trial name
- NCT07399366
- Testing
- Film-Based Medical Education and Social Justice Elective
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Polypharmacy, Adverse Drug Reaction
Deprescribing of Symptomatic Medications in Rehabilitative or Subacute Care Patients
Deprescribing is a systematic method of withdrawing potentially inappropriate or unnecessary medications and is warranted in the elderly due to the high prevalence of polypharmacy.
- Trial name
- NCT03354845
- Testing
- Deprescribing intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bright Vision Hospital
Kidney Transplant; Complications, Toxicity
Effect of Tacrolimus Formulation on Neurological Side Effects in Older Kidney Transplant Recipients
Previous studies have shown that elderly patients experience higher trough levels of tacrolimus and are more sensitive to the effects of medications, they experience higher occurrence and severity of such medication related…
- Conditions
- Kidney Transplant; Complications, Toxicity, Drug Toxicity, Neurotoxicity
- Trial name
- NCT03461445
- Testing
- Envarsus, IR Tacrolimus
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, Davis
Analgesia
Analgesic Effect of a New Analgesic Based Gel(Douloff) Versus Oral Paracetamol in Acute Soft Injuries
Herbal medicine is commonly used to treat pain, but little is known about its effectiveness and its place in the common arsenal of analgesics .The question of whether such herbal combinations could have similar efficacy to oral…
- Trial name
- DOULOFF (NCT05647681)
- Testing
- Douloff, paracetamol
- Volunteers
- 1,100 people
- Sponsor
- University of Monastir
Parkinson Disease
GM1 Ganglioside Effects on Parkinson's Disease
The purpose of this trial is to examine the short term effects (24 Weeks) of GM1 on Parkinson's disease (PD) symptoms, as well as the effects of long-term treatment (120 Weeks) with GM1 on disease progression, and to examine the…
- Trial name
- NCT00037830
- Testing
- GM1 ganglioside
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Thomas Jefferson University
Cancer, Cardiotoxicity
BIOMARKER and IMAGING CHARACTERISATION of INFLAMMATORY ATHEROMA in PATIENTS RECEIVING IMMUNOTHERAPY and ANGIOGENESIS INHIBITORS
The advent of immunotherapy (immune checkpoint inhibitors [ICI]) has been an extremely important advancement for cancer treatment in recent decades.
- Conditions
- Cancer, Cardiotoxicity, Atherosclerotic Disease
- Trial name
- BIOCAPRI (NCT06597045)
- Testing
- PET/CT with 18-FDG
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Kidney Transplant
Study Comparing Sirolimus With Cyclosporine in a Calcineurin Inhibitor (CNI)-Free Regimen in Kidney Transplant Recipients
The purpose of this study is to determine if one drug is superior to another with regard to safety and the preservation of renal function after a kidney transplant.
- Trial name
- NCT00137345
- Testing
- sirolimus
- Where
- 82 sites in United States, Argentina and 19 more
- Volunteers
- 500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Obstructive Sleep Apnea
Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy
This clinical trial will evaluate the effect of treatment with hypoglossal nerve stimulation on the underlying mechanisms of obstructive sleep apnea.
- Trial name
- HNS-CoDSE (NCT07337239)
- Testing
- Additional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Antwerp
Mental Retardation
Effect of Valproate on Propofol
The aim of this study is to evaluate the effect of valproate on the required dose of propofol for sedation in patients with mental retardation.
- Trial name
- NCT01170377
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Okayama University
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