Clinical trials: Effect of Drugs
Parkinson Disease, Dyskinesia, Drug-Induced
Open Label, Safety, Tolerability and Efficacy of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
The purpose of this study is to generate long-term safety, tolerability and efficacy data for AFQ056 in patients who have participated in and completed any AFQ056 phase II study in PD-LID (Parkinson's disease, L-dopa induced…
- Conditions
- Parkinson Disease, Dyskinesia, Drug-Induced, Levodopa
- Trial name
- NCT01173731
- Testing
- AFQ056
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 66 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Nephropathy, Medication Compliance
Effect of Low GI/ Glycemic Load (GL) Diet in Diabetic Nephropathy Patients
low GI and low GL diet have more beneficial effect for diabetic nephropath patients compared with conventional diet. low GL may have more favorable effect than low GI diet.
- Trial name
- NCT02384902
- Testing
- low GI, conventional diet
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Isfahan University of Medical Sciences
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)
Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn…
- Trial name
- TEN metabolism (NCT05320653)
- Testing
- Medical nutrition
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pharmacokinetics of Isavuconazole, Pharmacokinetics of Ethinyl Estradiol and Norethindrone
Drug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone
The purpose of this study is to assess the effect of multiple doses of isavuconazole on the pharmacokinetics (PK) of a single dose of contraceptive in healthy post-menopausal women.
- Conditions
- Pharmacokinetics of Isavuconazole, Pharmacokinetics of Ethinyl Estradiol and Norethindrone, Healthy Volunteers
- Trial name
- NCT01597986
- Testing
- isavuconazole, Oral Contraceptive (ethinyl estradiol / norethindrone)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Healty Male Volunteers
CKD-397 Drug-drug Interaction Study (B)
The purpose of this study is to investigate to effect of tadalafil on the pharmacokinetic properies of tamsulosin
- Trial name
- CKD-397DDI(B) (NCT02247505)
- Testing
- Harnal-D Cap. 0.2mg, Cialis Tab. 5mg
- Where
- South Korea
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Glioblastoma
Bioavailability of Disulfiram and Metformin in Glioblastomas
Neuro-oncological trials may fail due to the drug never getting to the intended target (i.e. within the tumor micro environment).
- Trial name
- INSIDE (NCT03151772)
- Testing
- Disulfiram, Metformin
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Sahlgrenska University Hospital
Critical Illness, Respiratory Distress Syndrome, Adult
The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium
Pathophysiological changes influenced by multiple factors in critically ill patients, has a significant impact on pharmacokinetics (PK) and pharmacodynamics (PD) of cisatracurium.
- Conditions
- Critical Illness, Respiratory Distress Syndrome, Adult, Neuromuscular Blockade, Respiratory Failure
- Trial name
- NCT03337373
- Testing
- cisatracurium
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Colorectal Neoplasms, Anesthesia
Effects of Anesthetic Techniques on Time to Start of Adjuvant Chemotherapy Following Surgery for Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer in the world with a high postoperative mortality (2 - 6%) as well as a low 5-year survival (40%).
- Conditions
- Colorectal Neoplasms, Anesthesia, Drug Therapy, Surgery
- Trial name
- ENCORE (NCT04493905)
- Where
- Sweden
- Volunteers
- 5,500 people
- Sponsor
- European Society of Anaesthesiology
Breast Cancer, Neoplasm, Breast
Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
Breast cancer is the most commonly cancer in women in the overall global population. According to the World Cancer Research Fund International, there were more than 2.25 million new cases of breast cancer in women in 2020.
- Conditions
- Breast Cancer, Neoplasm, Breast, Breast Diseases, Antihypertensive Agents
- Trial name
- NCT05465031
- Testing
- Sacubitril-valsartan
- Where
- 4 sites in Poland
- Volunteers
- 600 people
- Sponsor
- Silesian Centre for Heart Diseases
Cardiovascular Diseases, Healthy Lifestyle
Effects of Integrated Cardiovascular Health Education Program on Older Adults at Risk of ASCVD
Despite older adults being exposed to an increased risk of atherosclerotic cardiovascular disease (ASCVD), they are generally underrepresented in cardiovascular prevention programmes.
- Conditions
- Cardiovascular Diseases, Healthy Lifestyle, Health Education
- Trial name
- NCT05434273
- Testing
- HE programme, Usual care
- Where
- Hong Kong
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Low Back Pain
Interprofessional Rehabilitation for Adults With Chronic Non-specific Low Back Pain
The primary aim of the study is to analyse the long-term effectiveness of an interprofessional and interdisciplinary rehabilitation program named "PASTOR", with a biopsychosocial approach for participants with chronic…
- Trial name
- PASTOR (NCT02056951)
- Testing
- Multidisciplinary rehabilitation, Interprofessional rehabilitation
- Where
- 4 sites in Germany
- Volunteers
- 536 people
- Sponsor
- University of Erlangen-Nürnberg
Obesity, Metabolic Syndrome X
Treatment of Antipsychotic-associated Obesity With a GLP-1 Analogue
To examine if 3 months of treatment with a GLP-1 (glucagon-like-peptide-1) analogue can induce weight loss in obese, non-diabetic patients with a diagnosis within the schizophrenic spectrum.
- Conditions
- Obesity, Metabolic Syndrome X, Drug-induced Obesity, Schizophrenia
- Trial name
- TAO (NCT01794429)
- Testing
- Exenatide
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Bjorn H. Ebdrup
DNA Sequencing
Ivermectin Neurotoxicity and ABCB1 Gene Mutations
The study report a unique case of severe intoxication in a child treated with oral ivermectin to prevent scabies infection. The ABCB1 gene sequencing found the child compound heterozygote for two nonsense mutations, one in each…
- Trial name
- NCT04174469
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier
Asthma
Clinical Effect of Reflexology and Homeopathy Added to Conventional Asthma Management
There is a lack of scientific evidence that homeopathy and reflexology is effective treatment of asthma. Systematic reviews have found that many clinical trials testing homeopathy and reflexology have major flaws, such as small…
- Trial name
- NCT01426061
- Testing
- Reflexology plus conventional treatment, Homeopathy plus conventional treatment, Conventional treatment
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- University of Aarhus
Nonalcoholic Fatty Liver, Osteoporosis, Postmenopausal
Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is a chronic, metabolic liver disease that is closely related to obesity, type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) in a bidirectional mode.
- Trial name
- OsteoNAFLD (NCT05493761)
- Testing
- Denosumab, Alendronate Sodium
- Where
- 3 sites in Greece
- Volunteers
- 72 people
- Sponsor
- Aristotle University Of Thessaloniki
Drug-induced Weight Gain
Effect of RDX-002 on Postprandial Triglycerides in Subjects Treated With Olanzapine
This Phase 1b Study RDX-002-22-09 has been planned to evaluate the effect of RDX-002 on postprandial triglycerides and ApoB48 levels in normal healthy subjects treated with the atypical antipsychotic drug, olanzapine.
- Trial name
- NCT05857566
- Testing
- RDX-002 + Olanzipine, Olanzapine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Response Pharmaceuticals
Inflammatory Bowel Disease (IBD), Medication Compliance
Telehealth Monitoring in Inflammatory Bowel Disease: Effects on Medication Compliance, Self-Efficacy, and Quality of Life
This randomized controlled trial aims to evaluate the effect of nurse-led telehealth monitoring on medication adherence, self-efficacy, and quality of life in individuals with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Disease (IBD), Medication Compliance, Quality of Life, Telehealth Monitoring
- Trial name
- NCT06971627
- Testing
- Nurse-led Telehealth Monitoring Program, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
Infection, Human Immunodeficiency Virus
A Phase IV, Open Label, 4-period Cross-over Study to Investigate a Drug Interaction Between Lamivudine and Sorbitol Oral Solutions in Healthy Volunteers
Lamivudine (3TC) is a nucleoside analogue indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and children.
- Trial name
- NCT02634073
- Testing
- Lamivudine, Sorbitol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Safety
Single Dose and Multiple Dose Escalation Trial of an Oral Formulation of MRX-4
A phase one study of the safety, tolerability, and pharmacokinetics of a new oxazolidinone antibiotic. Cohorts of healthy adults (female and male) will participate in: single dose escalation study of increasing doses of MRX-4…
- Trial name
- NCT03033342
- Testing
- Oral single doses of MRX-4, Oral multiple doses of MRX-4, MRX-4 co-administered with omeprazole
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- MicuRx
Colorectal Neoplasms, Diarrhea
Safety Study of the Chemotherapy Modulator PHY906 in Patients With Advanced Colorectal Cancer
The triple combination chemotherapy of irinotecan, 5-fluorouracil and leucovorin (CPT-11/5-FU/LV or Saltz regimen) is the treatment of choice for patients with advanced colorectal cancer.
- Trial name
- NCT00036517
- Testing
- PHY906
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- PhytoCeutica
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