Clinical trials: Effectiveness
Type 2 Diabetes Mellitus (T2DM), Obesity and Overweight
CK-0045 Proof-of-concept Study in Participants With Overweight / Obesity and Type 2 Diabetes
The goal of this clinical trial is to learn if treatment with CK-0045 improves blood sugar control after a meal in participants with type 2 diabetes mellitus (T2DM) and overweight/obesity.
- Trial name
- NCT06611930
- Testing
- CK-0045
- Where
- 2 sites in Germany
- Volunteers
- 90 people
- Sponsor
- Cytoki Pharma
Osteoarthritis
Efficacy of Myalgesin™ to Support Joint Function in Patients With Knee Osteoarthritis
Myalgesin is a botanical preparation consisting of celery seed extract,extract of dried Boswellia serrata, and dried extract of Phellodendron bark.
- Trial name
- NCT00577330
- Testing
- Myalgesin™ (celery seed extract, Boswellia serrata extract, Phellodendron extract)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- ProThera, Inc.
Sepsis
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Dose Exploration Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Characteristics of STC314 Injection Administered Intravenously in Sepsis Patients
One study evaluated the efficacy and safety of intravenous STC314 injection in patients with sepsis Sex and pharmacokinetic profiles of a multicenter, randomized, double-blind, placebo-controlled II Phase I dose exploration…
- Trial name
- Sepsis (NCT06548854)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Grand Medical Pty Ltd.
Arthroplasty, Replacement, Knee, Robotics
Comparison of Ambulatory and Functional Improvement by Morning Walk
The aim of this study is to determine the clinical efficacy and feasability of gait rehabilitation robot through approving functional improvement by an end-effector typed gait robot in patients underwent total knee arthroplasty.
- Trial name
- NCT03183856
- Testing
- Morning walk, no Morning walk
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Ulsan University Hospital
Chronic Pain, Insomnia
The Efficacy of CALPXT96™in Improving Sleep Quality in Patients With Chronic Non-cancer Pain
California Poppy has been traditionally used in Herbal Medicine as an analgesic, mild sedative and/or sleep aid. However there are no human clinical trial data to support its use.
- Trial name
- CALPXT96 (NCT02232256)
- Testing
- CALPXT96
- Where
- Canada
- Sponsor
- 9305-9954 Quebec Inc
Chronic Hepatitis B
Study to Evaluate the Efficacy and Safety of AHB-137 in Treatment-naive Participants With Chronic Hepatitis B (CHB)
The study is to evaluate the efficacy and safety of AHB-137 in CHB participants. The total duration of the study, including screening phase, treatment phase and follow-up phase.
- Trial name
- NCT06829329
- Testing
- AHB-137, NAs
- Where
- 6 sites in China
- Volunteers
- 105 people
- Sponsor
- Ausper Biopharma Co., Ltd.
Premature Birth
A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants
This study is designed to test the hypothesis that among infants born at less than 30 weeks, weighing less than 1500 g at delivery, and receiving initial respiratory support non-invasively or on invasive respiratory support and…
- Trial name
- NCT03085329
- Testing
- Seattle-PAP, Conventional bubble nasal CPAP
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Seattle Children's Hospital
Urothelial Carcinoma
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
This study is being done to see if a drug called disitamab vedotin, alone or with pembrolizumab, works to treat HER2 expressing urothelial cancer. It will also test how safe the drug is for participants.
- Trial name
- NCT04879329
- Testing
- disitamab vedotin, pembrolizumab
- Where
- 221 sites in United States, Argentina and 10 more
- Volunteers
- 372 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Constipation-predominant Irritable Bowel Syndrome
A Chinese Herbal Medicine for IBS-C
This double-blind, placebo-controlled randomized pilot clinical trial will test the hypothesis that granules of CDD-2105, a Chinese herbal medicine formula, will have efficacy in alleviating constipation and abdominal pain in…
- Trial name
- CDD2105RCT1 (NCT06319729)
- Testing
- CDD-2105
- Volunteers
- 78 people
- Sponsor
- Hong Kong Baptist University
Diabetes Mellitus Type 2
Effectiveness of Two Interventions in Patients With Low Educational Level With Diabetes to Reduce Inequalities in Self-care Behavior
The purpose of this cluster randomized trial is to determine whether an intervention implemented in a General Surgery, based in improving patient-provider communication, results in a better diabetes self-management in patients…
- Trial name
- NCT01849731
- Testing
- Face-to-face, Face-to-face intervention plus telephone reinforcement
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- Andalusian School of Public Health
Patients Hospitalized in the Hospices Civils of Lyon, COVID-19 Disease
Measurement of the Efficacy of MORPHINE in the Early Management of Dyspnea in COVID-19 Positive Patients
Morphine is used in the treatment of dyspnea and polypnea with a proven benefit on the improvement of these symptoms, both etiologically and symptomatically.
- Conditions
- Patients Hospitalized in the Hospices Civils of Lyon, COVID-19 Disease, Moderate to Severe Dyspnea, Without Resuscitation Objective Management
- Trial name
- CODYS (NCT04522037)
- Testing
- No intervention / Compare the difference in respiratory rate between H0 and H12 of the initiation of morphine between the control and interventional groups
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Common Variable Immunodeficiency
STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency
This study will determine whether an experimental medicine, STA-5326 mesylate, is safe to use in patients with common variable immunodeficiency (CVID) who have inflammation of the gut.
- Trial name
- NCT00263237
- Testing
- STA-5326
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hepatitis C
Real-world Effectiveness and Safety of Treatment With DAAs in Patients With CHC(Chronic Hepatitis C)
This is a multi-center, open-label clinical study. This study was aimed to assess the real-world effectiveness and safety of treatment with listed DAAs in patients with CHC and cirrhosis in Southern area of China.
- Trial name
- NCT03887637
- Testing
- DAAs
- Volunteers
- 180 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Primary Immune Thrombocytopenia
Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia
This is a Phase 2, open-label, multicenter, multiple subcutaneous injection, safety and efficacy study of PF-06835375 in adult participants with primary immune thrombocytopenia (ITP).
- Trial name
- NCT05070845
- Testing
- PF-06835375
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 61 people
- Sponsor
- Pfizer
Neurotoxicity, Pain
Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
RATIONALE: Lamotrigine may be effective in reducing pain, numbness, tingling, and other symptoms of peripheral neuropathy. It is not yet known whether lamotrigine is effective in treating peripheral neuropathy caused by…
- Conditions
- Neurotoxicity, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00068445
- Testing
- lamotrigine
- Where
- 23 sites in United States
- Volunteers
- 131 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Primary Care, Advance Directives
Effectiveness Brief Information Advanced Directives Primary Care
The knowledge and completion of advanced directives (ADs) by the population is generally low. Primary care could develop a very important role to inform and assist in the preparation of this document because of its accessibility.
- Conditions
- Primary Care, Advance Directives, Randomized Controlled Trial
- Trial name
- NCT03302572
- Testing
- Brief information group
- Where
- Spain
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Crohn´s Disease
Trichuris Suis Ova (TSO) Suspension Versus Placebo in Active Crohn's Disease
This study will run in centers in Germany, Denmark, Austria, Czech Republic, and Switzerland, only. This proof-of-concept study aims to evaluate the efficacy of three doses of oral TSO suspension vs.
- Trial name
- TRUST-2 (NCT01279577)
- Testing
- Low dose TSO, Medium dose TSO, High dose TSO
- Where
- Germany
- Volunteers
- 254 people
- Sponsor
- Dr. Falk Pharma GmbH
Enuresis, Nocturnal
The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings.
The aim of this study is to investigate the importance of clinical characterization of children with monosymptomatic nocturnal enuresis (MNE) in order to improve treatment efficacy.
- Trial name
- DRYCHILD (NCT03389412)
- Testing
- Desmopressin, Conditional alarm
- Where
- 6 sites in Belgium, China and 2 more
- Volunteers
- 324 people
- Sponsor
- University of Aarhus
Trigeminal Neuralgia
A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia
This is a double-blind, randomized withdrawal study comparing CNV1014802 with placebo in patients with trigeminal neuralgia who have successfully responded to CNV1014802 in an initial open-label phase.
- Trial name
- NCT01540630
- Testing
- CNV1014802
- Where
- United Kingdom
- Volunteers
- 67 people
- Sponsor
- Biogen
Lateral Patellar Syndrome
To Compare the Clinical Efficacy of Arthroscopic Lateral Retinacular Release and Exercise Therapy in the Treatment of Lateral Patellar Crush Syndrome
One hundred patients with lateral patellar compression syndrome (LPCS) were recruited and divided into two groups: arthroscopic treatment group and rehabilitation conservative treatment group.
- Trial name
- NCT06988930
- Testing
- Control group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
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