Clinical trials: Effectiveness
Diabetes Mellitus, Hypertension
Effectiveness of Home-Based Health Messaging for Patients With Hypertension and Diabetes
Patients treated at Veterans Affairs (VA) medical centers are older and have multiple chronic conditions. Two of the most common conditions in the VA population are hypertension (HTN) and Type 2 diabetes (DM).
- Trial name
- NCT00119054
- Testing
- In Home Health Messaging Device
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Alzheimer Disease
ADvance II Study: DBS-f in Patients With Mild Alzheimer's Disease
The primary efficacy objective of this study is to test the hypothesis that DBS-f stimulation (ON) will slow cognitive and functional progression of AD, as compared to no stimulation (OFF), by measuring baseline…
- Trial name
- NCT03622905
- Testing
- DBS-f On, DBS Off
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 74 people
- Sponsor
- Functional Neuromodulation Ltd
Atopic Dermatitis
Long-term Extension Trial in Subjects With Atopic Dermatitis Who Participated in Previous Tralokinumab Trials - ECZTEND
The purpose of this extension trial is to evaluate the long-term safety of tralokinumab.
- Trial name
- NCT03587805
- Testing
- Tralokinumab
- Where
- 309 sites in United States, Belgium and 9 more
- Volunteers
- 1,672 people
- Sponsor
- LEO Pharma
α-thalassemia
the Safety and Efficacy Evaluation of HGI-002 Injection in Patients With Transfusion-Dependent α-Thalassemia
This is an open label study to evaluate the safety and efficacy of α-globin Restored Autologous Hematopoietic Stem Cells in α-Thalassemia Major Patients
- Trial name
- NCT05851105
- Testing
- α-globin restored autologous hematopoietic stem cells
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shenzhen Hemogen
Cold Agglutinin Disease
Therapy for Chronic Cold Agglutinin Disease
Chronic cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (anemia due to destruction of red blood cells by abnormal antibodies).
- Trial name
- NCT00373594
- Testing
- Rituximab, Fludarabine
- Where
- 6 sites in Norway, Russia
- Volunteers
- 30 people
- Sponsor
- University of Bergen
Heel Pain, Plantar Fasciitis
Effectiveness of Podiatry on Plantar Pain
MAIN OBJECTIVE: To value the effectiveness of the different quiropody interventions in the heel pain. SECONDARY OBJECTIVES: To evaluate the effectiveness of lasw different technologies in front of each one of the other…
- Conditions
- Heel Pain, Plantar Fasciitis, Plantar Pain
- Trial name
- EPOPLAPAIN (NCT00888394)
- Testing
- chiropody, basic orthesis, advantage orthesis
- Where
- 2 sites in Spain
- Volunteers
- 312 people
- Sponsor
- University of Malaga
Gastric Intestinal Metaplasia, Treatment
RFA for GIM Treatment
Use radiofrequency ablation (RFA) for Gastric intestinal metaplasia (GIM) treatment.
- Conditions
- Gastric Intestinal Metaplasia, Treatment, Radio-frequency Ablation
- Trial name
- NCT04348266
- Testing
- Radiofrequency ablation (RFA)
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Major Depression Disorder
Predictive Effect of Neuroinflammatory Factors of the MECT in Treatment of Senile Depression
To compare the correlation between the clinical efficacy of MECT treatment and baseline, 3 times, 8 times of treatment, 1 week after treatment, and 2 weeks after treatment in patients with depression and suicidal ideation.
- Trial name
- NCT05597566
- Testing
- modified electroconvulsive therapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Qinge Zhang
Diabetes Mellitus, Type 1, Overweight and Obesity
ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)
An initial pilot and feasibility study will be conducted using a Sequential, Multiple Assignment, Randomized Trial (SMART) design to identify acceptable and effective dietary strategies to optimize both glycemic control and…
- Trial name
- ACT1ON DP3 (NCT03651622)
- Testing
- Hypocaloric, low carbohydrate diet, Hypocaloric, moderate low fat diet, Mediterranean diet, no caloric restriction
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Overweight, Obesity
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
This is a study of tirzepatide in participants with overweight and obesity. The main purpose is to learn more about how tirzepatide affects body weight. The study has two phases: A main phase and an extension phase.
- Trial name
- SURMOUNT-1 (NCT04184622)
- Testing
- Tirzepatide
- Where
- 118 sites in United States, Argentina and 8 more
- Volunteers
- 2,539 people
- Sponsor
- Eli Lilly and Company
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Comparative Study on the Efficacy and Safety of Microwave Ablation and Lobectomy in the Treatment of Ground Glass Nodules Located in the Pulmonary Hilar Region
GGO is a characteristic focus of early lung cancer. Due to the abundant peripheral blood vessels and bronchial tissues around the GGO lesions located in pulmonary hilar, only lobectomy could be used for the surgical treat of…
- Trial name
- NCT05477251
- Testing
- microwave ablation, lobectomy
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Shoulder Joint Disorder
The Effectiveness of Megadose Shinbaro Pharmacopuncture for Patients With Chronic Shoulder Pain
This study is a prospective, case-control observational trial. The investigators will compare the Megadose Shinbaro Pharmacopuncture group to the control group to analyze the effectiveness of shoulder Megadose Shinbaro…
- Trial name
- NCT04222829
- Testing
- Megadose Shinbaro Pharmacopuncture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Jaseng Medical Foundation
Type 1 Diabetes
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).
- Trial name
- SAFEGUARD (NCT07187531)
- Testing
- High Dose SAB-142, Low Dose SAB-142
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 159 people
- Sponsor
- SAb Biotherapeutics, Inc.
Anal Squamous Cell Carcinoma, Colorectal Neoplasms
Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers
REFIT-MSS is a non-randomized, multicenter, open-label, multi-cohort, 2-stage, phase II trial to evaluate the efficacy and safety of regorafenib in combination with tislelizumab (referred as Rego-Tisle) in adult patients with…
- Conditions
- Anal Squamous Cell Carcinoma, Colorectal Neoplasms, Soft Tissue Sarcoma, Malignant Pleural Mesothelioma
- Trial name
- REFIT-MSS (NCT05582031)
- Testing
- Regorafenib in combination with Tislelizumab
- Sponsor
- Translational Research in Oncology
Dementia, Cognitive Impairment
Effective Strategies for Dementia Care
The purpose of this study is to determine whether the interventions of Snoezelen, structured reminiscence therapy and 10-minutes activation are effective to reduce apathy in long term care residents with dementia.
- Trial name
- WISDE (NCT00653731)
- Testing
- Snoezelen ©, structured reminiscence therapy, 10-minutes activation
- Where
- Germany
- Volunteers
- 327 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Geographic Atrophy
A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled study evaluating the efficacy and safety of lampalizumab administered by intravitreal injections in participants with geographic atrophy…
- Trial name
- SPECTRI (NCT02247531)
- Testing
- Lampalizumab
- Where
- 153 sites in United States, Argentina and 20 more
- Volunteers
- 975 people
- Sponsor
- Hoffmann-La Roche
Ankle Inversion Sprain, Chronic Instability of Joint
Effectiveness of Balance Training and Dynamic Neuromuscular Stabilization Training in Amateur Athletes with Chronic Ankle Instability
The goal of this clinical trial is to determine and compare the effects of balance and dynamic neuromuscular stabilization training on ankle function ability, functional instability severity, physical activity level, muscle…
- Conditions
- Ankle Inversion Sprain, Chronic Instability of Joint, Chronic Pain, Athlete Foot
- Trial name
- NCT06296537
- Testing
- Dynamic Neuromuscular Stabilization Training (DNS), Balance Training, Conventional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Medipol University
Pain, Postoperative
Study Of The Efficacy And Safety Of Pregabalin Compared To Placebo For Treatment Of Post-Surgical Pain From Hysterectomy
To assess the efficacy of pregabalin compared to placebo on pain following hysterectomy , measured using subject reported assessments of pain.
- Trial name
- NCT00468845
- Testing
- pregabalin (Lyrica)
- Where
- 42 sites in United States, Canada and 7 more
- Volunteers
- 501 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Lung, Diseases
Non-invasive Ventilation Assisted Fiber-optic Bronchoscopy
The purpose of this study is the evaluation of using bi-level positive airway pressure ventilation in candidates for fiber-optic bronchoscopy regarding benefits and drawbacks.
- Trial name
- NCT06115395
- Testing
- non- invasive ventilator, fiber-optic bronchoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Advanced Solid Tumor, Metastatic Solid Tumor
A Phase I Study of WM-S1-030 in Patients With Advanced Solid Tumors
This study evaluates the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WM-S1-030 in patients with advanced solid tumors.
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Colorectal Cancer, Lung Cancer
- Trial name
- NCT04801095
- Testing
- WM-S1-030
- Where
- 6 sites in Australia, South Korea
- Volunteers
- 100 people
- Sponsor
- Wellmarker Bio
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