Clinical trials: Effectiveness
Aneurysm, Abdominal Aortic
First-in-Human Trial of the A3-Shield System for Stabilizing Abdominal Aortic Aneurysms
This clinical trial evaluates the safety and feasibility of the A3-Shield implant for stabilising small abdominal aortic aneurysms in adult patients.
- Trial name
- PRINCIPIIS-FIH (NCT07330752)
- Testing
- A3-Shield Implantation
- Where
- Uzbekistan
- Volunteers
- 12 people
- Sponsor
- Angiolutions GmbH
Parenting
Evaluation of the Comprehensive Family Support Program (PAIF)
The goal of this study is to evaluate the effectiveness of positive parenting programs targeted to parents of toddlers, children and adolescents carried out in Cantabria (Spain).
- Trial name
- NCT06285552
- Testing
- Positive parenting PAIF program
- Where
- Spain
- Volunteers
- 1,429 people, healthy volunteers welcome
- Sponsor
- University of Seville
Childhood Obesity, Overweight and Obese Children
Development and Evaluation of a Web-based Parental Role Modeling Program for Childhood Obesity Management
The goal of this clinical trial is to learn whether an online family health education program can help Vietnamese children aged 7-9 years with overweight or obesity develop healthier habits.
- Conditions
- Childhood Obesity, Overweight and Obese Children, Pediatric Obesity, Overweight and Obesity in Schoolchildren
- Trial name
- NCT07641452
- Testing
- Web-based parental role modeling program, Standard health education materials
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Do Thi Thu Huyen
COPD, Emphysema
Implementing and Evaluating the Genie Tool in COPD
The Generating Engagement in Network Involvement (GENIE) Tool is designed to support people to find and join social activities in their own neighbourhoods.
- Trial name
- GeCop (NCT02935452)
- Testing
- GENIE - social networking tool
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Southampton
Recurrent Breast Cancer, Metastatic Breast Cancer
B002 in Patients With HER2-positive Breast Cancer
To assess the safety and tolerability characteristics of B002 in patients with HER2-positive recurrent or metastatic breast cancer. The dose-limiting toxicity (DLT) was assessed and the maximum tolerated dose (MTD) was explored.
- Trial name
- B002-101 (NCT04382352)
- Testing
- Humanized Anti-HER2 Monoclonal Antibody Compound for Injection .R&D code: B002.
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Bone Metastases, Castration-Resistant Prostate Cancer
A Study of Alpharadin With Docetaxel in Patients With Bone Metastasis From Castration-Resistant Prostate Cancer (CRPC)
The main purpose of this study is to establish a recommended dose of Alpharadin to be used in combination with docetaxel in patients with bone metastases from castration-resistant prostate cancer and to investigate safety and…
- Trial name
- NCT01106352
- Testing
- Radium-223 dichloride (Xofigo, BAY88-8223), Docetaxel
- Where
- 7 sites in United States, France
- Volunteers
- 70 people
- Sponsor
- Bayer
Phobias, Acrophobia
Intelligent Virtual Reality Therapy System and Testing Its Clinical Efficacy
Objective: To take the existing VR technology to the next level, the investigators developed a novel Intelligent Virtual Reality Therapy System (IVRTS).
- Conditions
- Phobias, Acrophobia, Anxiety
- Trial name
- IVRTS (NCT04620447)
- Testing
- Intelligent Virtual Reality Therapy System (IVRTS)
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College of Medical Sciences, India
Efficacy, Self
Efficacy of Sublingual Versus Subcutaneous Allergen Immunotherapy in Patients With Bronchial Asthma
Asthma is characterized by airway inflammation and is manifested by acute episodes of obstruction related to loss of control of airway inflammation mostly in response to a viral respiratory tract infection .The significance of…
- Trial name
- Sublingual (NCT05786638)
- Testing
- Allergen Immunotherapy Extract
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University Hospital
Degenerative Disc Disease
XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)
The purpose of this study is to evaluate the safety and effectiveness of XL TDR in patients with single-level degenerative disc disease compared to other devices approved by the FDA for the same or similar indications.
- Trial name
- XL TDR (NCT00927238)
- Testing
- XL TDR, Lumbar fusion surgery
- Where
- 17 sites in United States
- Volunteers
- 246 people
- Sponsor
- NuVasive
Autism Spectrum Disorders
Effectiveness of Early Intervention in an Underserved Population
The purpose of this study is to test the applicability of a caregiver-implemented autism intervention protocol to a deliberately recruited low-income, underserved population.
- Trial name
- ESI-CO (NCT01250938)
- Testing
- ESI - Community Outreach
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of California, Los Angeles
Anxiety, Signs and Symptoms
Effectiveness of a Music Therapy Intervention in Cancer Patients Undergoing Active Treatment at the Jaén University Hospital: a Non-randomized Controlled Trial.
A cancer diagnosis and its clinical progression can cause patients physical, psychological, emotional, social, and spiritual distress.
- Conditions
- Anxiety, Signs and Symptoms, Oncologic Complications
- Trial name
- ECMONC (NCT07886658)
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Jaén
Type1diabetes
Personalized Automated Determination of Insulin Pump Setting for Subjects With Type 1 Diabetes Switching From MDI to Pump Therapy and Vice Versa- Safety and Efficacy Feasibility Study
The "MD-Logic Switch Advisor" is a software product that is designed to assist in insulin dosage decision making and has two components: A.
- Trial name
- NCT03574558
- Testing
- MD-Logic Switch Advisor
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Rabin Medical Center
Plaque Psoriasis
The Safety, Efficacy and Pharmacokinetics of ARQ-151 Cream in Subjects With Chronic Plaque Psoriasis
This is a parallel group, double blind, vehicle-controlled study in which roflumilast (ARQ-151) cream 0.3%, roflumilast cream 0.15%, or vehicle cream is applied once daily (QD) for 84 days to subjects with chronic plaque…
- Trial name
- ARQ-151-201 (NCT03638258)
- Testing
- Roflumilast Cream 0.3%, Roflumilast Cream 0.15%, Vehicle Cream
- Where
- 30 sites in United States, Canada
- Volunteers
- 331 people
- Sponsor
- Arcutis Biotherapeutics, Inc.
Enamel Caries
Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation
Double-blind, randomized, 3 group in situ study to assess effect of three toothpastes on enamel remineralization, as measured by change in integrated mineral loss (∆∆Z).
- Trial name
- NCT04155658
- Testing
- Experimental Toothpaste containing 1450ppm SMFP, Toothpaste containing 1450ppm SMFP, Toothpaste with no fluoride
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Hypercholesterolemia
LDL-Cholesterol Lowering Effect of KB2115 as Add on to Ezetimibe
Eprotirome (KB2115) is a liver selective thyroid hormone that can induce hyperthyroidism in the liver, while an euthyroid state is preserved in the extrahepatic tissue.
- Trial name
- NCT00677248
- Testing
- Eprotirome and ezetimibe
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karo Bio AB
Leukemia
Interleukin-2 in Treating Patients With Relapsed or Refractory Acute Myelogenous Leukemia
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill acute myelogenous leukemia cells. PURPOSE: Phase II trial to study the effectiveness of interleukin-2 in treating patients with acute myelogenous…
- Trial name
- NCT00003148
- Testing
- aldesleukin
- Where
- 10 sites in Austria, Belgium and 4 more
- Volunteers
- 86 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Wrinkle
Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
Study evaluating the efficacy of a micro coring device for the treatment of moderate to severe check wrinkles
- Trial name
- NCT03793348
- Testing
- MCD
- Where
- 6 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cytrellis Biosystems, Inc.
Advanced Lung Cancer
A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants…
- Trial name
- NCT06892548
- Testing
- BNT324, BNT327
- Where
- 91 sites in United States, Australia and 8 more
- Volunteers
- 594 people
- Sponsor
- BioNTech SE
Schizophrenia
Paliperidone Palmitate Effectiveness Assessment Registry - Longitudinal (PEARL)
The primary objective of this study is to determine if Australian patients with schizophrenia treated with paliperidone palmitate under conditions of continuous monitoring of outcomes over a 12-month period achieve relapse rates…
- Trial name
- NCT01362426
- Testing
- paliperidone palmitate
- Where
- 10 sites in Australia
- Volunteers
- 127 people
- Sponsor
- Janssen-Cilag Pty Ltd
Hypertrophic Obstructive Cardiomyopathy, Mitral Regurgitation
Mitral Regurgitation in Hypertrophic Obstructive Cardiomyopathy: Fix it in a Simple, Effective and Durable Way!
Septal myectomy is performed in selected cases to treat patients with hypertrophic obstructive cardiomyopathy (HOCM). The mechanism that causes obstruction involves both the outflow tract itself and the mitral apparatus, with the…
- Trial name
- NCT05850026
- Testing
- Septal myectomy and mitral valve repair with edge-to-edge technique
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Michele De Bonis
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