Clinical trials: Effects, Longterm
Type 2 Diabetes Mellitus
Sitagliptin (DPP-4 Inhibitor) and NPH Insulin in Patients With T2D
To compare the short and long term effects of inhibitor of the DPP-IV enzyme, sitagliptin , with bedtime NPH insulin in patients with T2D inadequately controlled with sulphonylurea plus biguanide: effects on beta cell function…
- Trial name
- NCT02607410
- Testing
- sitagliptin, NPH insulin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Asthma in Children
The Long-term Effect of RSV Infection
Respiratory Syncytial Virus (RSV) is a leading cause of childhood illness and hospitalization across the world. In addition to acute mortality and morbidity, RSV infection is associated with developing recurrent wheeze in…
- Trial name
- NCT03876249
- Testing
- exposure to RSV
- Volunteers
- 2,000 people
- Sponsor
- Child Health Research Foundation, Bangladesh
Myoma, Uterine Bleeding, Dysfunctional
Observation of Long-term Effects on Endometrium and Uterine Fibroids in Women With Ulipristal Acetate Therapy
A prospective observational study on italian women undergoing ulipristal acetate (uPa) therapy for symptomatic myomas and its impact on symptomatology and moreover on myomas architecture.
- Conditions
- Myoma, Uterine Bleeding, Dysfunctional, Uterine Bleeding Heavy, Dysmenorrhea
- Trial name
- NCT03972917
- Testing
- Transvaginal ultrasonographic examination
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Campania Luigi Vanvitelli
Brain Vascular Function, Cerebral Blood Flow
Mixed Nuts and Brain Vascular Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Trial name
- NCT04210869
- Testing
- Mixed Nuts
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cardiac Implantable Electronic Device (CIED), Shoulder Dysfunction
Long-term Effects of Early Shoulder Exercise After CIED Implantation
Shoulder dysfunction frequently occurs after cardiac implantable electronic device (CIED) implantation, adversely affecting quality of life.
- Trial name
- NCT07496554
- Testing
- Structured Stretching and Strengthening Program, Standard Post-operative Care, Pendulum Exercise Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Multiple Sclerosis
Long-Term Effects of Torso-Weighting
The goal of this pilot study is to test the protocol for investigating the longer-term effects of torso weighting on physical activity, number of falls, and muscle activation (when muscles turn on and off and how intensely) in…
- Trial name
- TWPS (NCT02743312)
- Testing
- Torso Weights, Fitbit Flex
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- San Francisco State University
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy
RATIONALE: Gathering information about how young patients with ependymoma respond to standard combination chemotherapy and learning about the long-term effects of this treatment may help doctors plan better treatment.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Children, Ototoxicity
- Trial name
- NCT00683319
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- 10 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Long Haul COVID, Postural Orthostatic Tachycardia Syndrome
Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort
The purpose of the study is three-fold. The primary aim is to identify the proportion of Long-Haul COVID (LHC) and non-LHC volunteers with relevant symptoms actually have postural orthostatic tachycardia syndrome (POTS).
- Trial name
- COVIVA (NCT05481177)
- Testing
- Ivabradine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Uniformed Services University of the Health Sciences
Diabetes Mellitus Type 1
Long Term CGM Treatment in Patients With Type 1 Diabetes Treated With Insulin Injections
A keystone in preventing diabetic complications in patients with type 1 diabetes is good glycaemic control. Frequent self-measurements of blood glucose (SMBG) levels have been an essential part of insulin dosing before meals.
- Trial name
- NCT02465411
- Testing
- Dexcom G4 or later generation
- Where
- 15 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Vastra Gotaland Region
Type 1 Diabetes
Long Term Effects of Diabetes of Very Young Children
To investigate neurocognitive and behavioral measures in 25 children aged 6-10 years diagnosed with diabetes for > 5 years who have received long-term insulin pump therapy (> 3 years) compared to a group of children matched for…
- Trial name
- NCT00707629
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Indiana University
Behavior Problem, Development Delay
Family Nurture Intervention, A Group Model in Connecticut
The purpose of this current study is to investigate the efficacy of a group model of Family Nurture Intervention in ameliorating behavioral problems in preschool-aged children.
- Conditions
- Behavior Problem, Development Delay, Emotional Disturbance, Family Conflict
- Trial name
- NCT02970565
- Testing
- Family Nurture Intervention, Nutrition and Play Intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sickle Cell Disease
Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease
The primary objectives of this prospective, observational study are (1) to describe the long-term cellular, molecular, and clinical effects of hydroxyurea therapy in sickle cell disease, and (2) to perform hydroxyurea…
- Trial name
- NCT00305175
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer
Short and Long Term Effects of a Physical Therapy Program After Breast Cancer Surgery
Objectives: To evaluate the pressure pain threshold, shoulder biomechanics, cardiorespiratory function and the quality of life associated with the short and long-term physical therapy rehabilitation following breast cancer…
- Trial name
- NCT04116281
- Testing
- Rehabilitation after breast cancer surgery
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidade Federal de Sao Carlos
Atrial Fibrillation
Radiofrequency Ablation Versus Balloon Cryoablation in Elderly Patients With Atrial Fibrillation
This study compares the procedural characteristics and effectivity of radiofrequency ablation and cryoablation in patients with atrial fibrillation that are 75 years or older.
- Trial name
- NCT04337567
- Testing
- radiofrequency ablation, ballon cryoablation
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Vivantes Netzwerk für Gesundheit GmbH
Long-term Effects Secondary to Cancer Therapy in Children, Sarcoma
Health-Related Outcomes in Patients Who Were Previously Treated for Rhabdomyosarcoma
RATIONALE: Cancer treatment may have risks that affect health outcomes later. It is not yet known what health outcomes may be related to previous treatment for rhabdomyosarcoma.
- Trial name
- NCT00003801
- Testing
- management of therapy complications, quality-of-life assessment
- Sponsor
- National Cancer Institute (NCI)
β-Thalassemia
Extension Study to Evaluate the Safety and Efficacy of Luspatercept in Participants With β-Thalassemia Previously Enrolled in A536-04 (A536-06/MK-6143-004)
Study A536-06 (MK-6143-004) is an open-label extension study for participants previously enrolled in study A536-04 (NCT01749540), to evaluate the long-term safety and tolerability of luspatercept in adult participants with…
- Trial name
- NCT02268409
- Testing
- luspatercept
- Where
- 7 sites in Greece, Italy
- Volunteers
- 51 people
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Knee Osteoarthritis
Effect of Physiotherapy After Total Knee Replacement
Physiotherapy plays an important part in rehabilitation after total knee arthroplasty. Even if this is a common practice, few studies have been performed on this issue.
- Trial name
- NCT00807716
- Testing
- walking skill group, usual physiotherapy care
- Where
- Norway
- Volunteers
- 57 people
- Sponsor
- University of Oslo
Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
The Long-term Effect of Tianqi Capsule Interventions to Prevent Diabetes in the REDUCES Study: a 8-year Follow-up Study
Objectives: This study is aimed to assess whether Tianqi Capsule interventions have a long-term effect on the risk of diabetes and provide evidence that early intervention by traditional Chinese medicine could delay the…
- Trial name
- NCT02848053
- Testing
- no intervention
- Volunteers
- 420 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Hepato-Renal Syndrome, Portal Hypertension
MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)
Heptorenal syndrome (HRS) is divided into two types. A non-acute kidney injury (NAKI-HRS), which is predominantly related to end-stage disease and a more acute kidney injury (HRS-AKI).
- Conditions
- Hepato-Renal Syndrome, Portal Hypertension, Acute Kidney Injury, Liver Diseases
- Trial name
- NCT03483272
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Hvidovre University Hospital
Anxiety Disorder, Head and Neck Cancer
Study of Anxiety and Avoidance of Others in Patients Previously Treated for Head and Neck Cancer
RATIONALE: Patients who undergo treatment for head and neck cancer may become anxious and avoid contact with other people. Learning how cancer treatment may cause anxiety in patients with head and neck cancer may help improve the…
- Conditions
- Anxiety Disorder, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00483639
- Testing
- Medical chart review, Liebowitz Social Anxiety Scale and the Social Phobia and Anxiety Inventory, management of therapy complications
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt-Ingram Cancer Center