Clinical trials: Effects, Longterm
Type 2 Diabetes, Obesity
Effects of Caloric Restriction in Obesity and Type 2 Diabetes
The study investigates whether a long-term 25% caloric restriction can prevent onset and/or progression of renal function deterioration, retinal involvement and cardiovascular complications in overweight/obese type 2 diabetic…
- Trial name
- CRESO2 (NCT01930136)
- Testing
- Calorie restriction (25%), Ad libitum health diet
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Acute Pain
Acute Pain Episodes in Patients Under Opioid Maintenance Therapy : Clinical Management and Long Term Effects
To define a rational pharmacological management of pain for the subjects under opioid maintenance therapy (methadone or buprenorphine), it is first of all necessary to estimate the efficiency of the current practices on pain…
- Trial name
- NCT00738036
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Toulouse
Obscure Gastrointestinal Bleeding, Angiodysplasia
Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation
Background: Repeated episodes of bleeding from gastrointestinal vascular malformations refractory to endoscopic or surgical therapy often pose a major therapeutic challenge.
- Conditions
- Obscure Gastrointestinal Bleeding, Angiodysplasia, Gastric Antral Vascular Ectasia, Thalidomide
- Trial name
- NCT00964496
- Testing
- Thalidomide, Iron
- Volunteers
- 55 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Overweight, Obesity
SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial
Participants are being asked to participate in SELECT-LIFE study because participants take part in the SELECT trial. SELECT-LIFE study is a survey-based study that will start when the SELECT trial ends.
- Trial name
- SELECT-LIFE (NCT04972721)
- Testing
- No treatment given
- Where
- 38 sites in United States, Algeria and 22 more
- Volunteers
- 3,439 people
- Sponsor
- Novo Nordisk A/S
Coronary Artery Disease, Percutaneous Coronary Intervention
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.
Patients who undergo percutaneous coronary intervention (PCI) are commonly treated with antiplatelet therapy to prevent stent thrombosis and recurrence of events.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndromes, Antiplatelet Therapy
- Trial name
- HI-TECH 2 (NCT07582835)
- Testing
- Clopidogrel, Ticagrelor, Prasugrel
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Cardiocentro Ticino
Multiple Sclerosis
Retrospective Observational Study About Long-term Effect of Fampridine in Patients With Multiple Sclerosis
Mobility problems in multiple sclerosis (MS) is a frequent symptom. It might appear in almost 93% of patients in the first 15 years of the disease, being a clear problem for their normal living.
- Trial name
- RETROFAM (NCT02966808)
- Testing
- cognitive and behavioural questionnaires
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Peripheral Artery Disease, Diabetes Mellitus
Cocoa Flavanols and Painfree Walking Distance
To characterize potential vascular long-term effects of flavanols in patients with peripheral artery occlusive disease (PAOD), a placebo-controlled double-blinded randomized control study will be performed in 62 patients…
- Trial name
- NCT01064583
- Testing
- cocoa
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Sacroiliac Joint Dysfunction
Muscle Energy Techniques and Sacral Manipulation on Pain, Functional Disability and Quality of Life
The study will be randomized clinical trial. This study will be conducted in University of Lahore Teaching Hospital, Lahore, Pakistan.
- Trial name
- NCT05018780
- Testing
- Muscle Energy Technique, Sacral Manipulation
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- University of Lahore
Aspirin, Drug Safety
Pharmacy Based Pharmacoepidemiological Observational Study With Aspirin Protect 100 mg
In this non-interventional one year study, data about overall and particularly gastrointestinal tolerability, indications, cardiovascular risk factors and compliance are collected by basic questionnaires, which are handed out by…
- Conditions
- Aspirin, Drug Safety, Effects, Longterm
- Trial name
- NCT01669824
- Testing
- Acetylsalicylic acid (Aspirin, BAYE4465)
- Where
- Germany
- Volunteers
- 4,235 people
- Sponsor
- Bayer
COVID-19, SAR-CoV-2
Long-term Effects of COVID-19
The purpose of this study is to measure, monitor, and analyze long term effects of SARS-CoV-2. The main purpose is to assess the post-hospitalization outcomes of patients who were diagnosed with SAR-CoV-2 by comparing to patients…
- Trial name
- NCT05220514
- Testing
- (R)-1-(2-chlorophenyl)- N-[11C] ([11C] PK11195), 2-(4-[11C]methylamino phenyl)-6-hydroxybenzothiazole (11C]6-OH-BTA-1 or [11C]PIB)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Mayo Clinic
Anemia, Sickle Cell
Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study)
Sickle cell anemia (SCA) is an inherited blood disorder that can cause organ damage. The BABY HUG study is evaluating the use of the medication hydroxyurea at preventing organ damage in children with SCA.
- Trial name
- NCT00890396
- Testing
- Hydroxyurea
- Where
- 14 sites in United States
- Volunteers
- 163 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hospice and Palliative Care Nursing, Terminally Ill Patients
The Short-Term and Long-Term Effects of Providing Mechanical Bath in Terminally Ill Patients
Providing mechanical bathing (MB) is a commonly used strategy to maintain cleanness and comfort in patients with terminally illness. However, extra devices, costs, and human resources are required for such service.
- Trial name
- NCT06620146
- Testing
- mechanical bathing
- Where
- Taiwan
- Volunteers
- 245 people
- Sponsor
- National Taiwan University Hospital
Carotid Artery Stenosis
Enterprise Stent Implantation in the Treatment of Carotid Artery Stenosis With Ischemic Stroke
To investigate the long-term effects of intracranial implantation of Enterprise stent system versus antiplatelet medication on neurologic deficits, daily living abilities, and carotid artery stenosis in patients with…
- Trial name
- NCT02802072
- Testing
- Enterprise stent implantation, Only aspirin medication
- Volunteers
- 100 people
- Sponsor
- Beijing Chao Yang Hospital
Skeletal Muscle Physiology
Testosterone-induced Muscle Memory and Underlying Mechanisms
The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.
- Trial name
- NCT06188767
- Testing
- Testosterone Undecanoate
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Obesity
Long-term Effects of Bariatric Surgery
The primary objective of LABS-2 is to use standardized techniques and measures to assess the longer-term safety and efficacy of bariatric surgery by: 1. comparing post-surgical outcomes to pre-operative status 2.
- Trial name
- LABS-2 (NCT00465829)
- Where
- 9 sites in United States
- Volunteers
- 2,458 people
- Sponsor
- University of Pittsburgh
Long-term Effects Secondary to Cancer Therapy in Children, Sarcoma
Health-Related Outcomes in Patients Who Were Previously Treated for Rhabdomyosarcoma
RATIONALE: Cancer treatment may have risks that affect health outcomes later. It is not yet known what health outcomes may be related to previous treatment for rhabdomyosarcoma.
- Trial name
- NCT00003801
- Testing
- management of therapy complications, quality-of-life assessment
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases, Coronary Arteriosclerosis
Long-Term Effects of Subclinical CAD on Cardiac Function
To assess changes in coronary calcium measured by electron beam computed tomography (EBCT) as a predictor of coronary heart disease (CHD) events.
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- NCT00006497
- Sponsor
- University of California, Irvine
Caries,Dental
Long-term Effects of a Lay Health Advisor Intervention on Immigrant Children's Caries
The aim of this study was to evaluate the long-term effectiveness of a lay health advisor (LHA) intervention on immigrant children's caries and preventive behaviors.This randomized controlled trial included mother-child pairs in…
- Trial name
- NCT04562675
- Testing
- LHA intervention, brochure-only
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
To Assess Long-term Effects of COVID-19 in Patients Who Were Affected With COVID -19
Assessment of Long-term Effects (Complications) of COVID-19 in the Southern Part of Bangladesh - a Retrospective Observational Study.
An outbreak of the novel coronavirus nCoV-19 (SARS-CoV-2), responsible for the coronavirus disease-19 (COVID-19), was first detected in Hubei province, Wuhan, China, on December 31, 2019.
- Trial name
- NCT04987736
- Testing
- RT-PCR
- Where
- Bangladesh
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Sher-E-Bangla Medical College
Cognitive Function, Growth
Long-term Effects of Iron and Zinc Supplementation During Infancy on Cognitive Performance and Growth
The hypotheses of this study are: 1. Compared to children who received a placebo, children who received iron or zinc or iron and zinc combined will perform better on cognitive tests and will have better growth status at ages 8 to…
- Trial name
- FeZn_FU (NCT00824304)
- Where
- Thailand
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Mahidol University