Clinical trials: Ejection Fraction
Heart Failure, Congestive
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a
Heart failure with preserved ejection fraction or HFpEF, represents nearly 50% of all heart failure cases and is particularly common in the elderly. The disease has no current treatment options.
- Trial name
- NCT02772068
- Testing
- Istaroxime, Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Benjamin Levine
Heart Failure With Preserved Ejection Fraction (HFpEF)
A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers
This is an open-label, non-randomized, fixed sequence study conducted at a single study center with primary aim to assess the pharmacokinetics (PK) of AZD9977 in healthy volunteers when administered alone and in combination with…
- Trial name
- NCT03843060
- Testing
- AZD9977, Itraconazole
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure With Preserved Ejection Fraction, Non Alcoholic Fatty Liver
Relationship Between Heart Failure With Preserved Ejection Fraction and Nonalcoholic Fatty Liver Disease.
The aim of our study to determine the demography, relation between patients with heart failure with preserved ejection fraction and those with nonalcoholic fatty liver disease in Sohag university hospital.
- Trial name
- NCT05822622
- Testing
- echocardiography
- Where
- 2 sites in Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Heart Failure
The Role of Chronotropic Incompetence in Heart Failure With Normal Ejection Fraction (HFNEF)
What is heart failure with normal ejection fraction? The heart contracts (pumps) and relaxes with each heartbeat. In some people with heart failure, the heart contracts normally but there is reduced relaxation of the heart.
- Trial name
- NCT02354573
- Testing
- Ivabradine
- Where
- United Kingdom
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Type 2 Diabetes Mellitus in Obese, Heart Failure With Preserved Ejection Fraction
Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
Our goal of the study is to learn the effects of the diabetes medication named Pioglitazone, in type-2 diabetic obese participants with Heart failure. The main question it aims to answer are: 1.
- Trial name
- PIOHF (NCT05838287)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Heart Failure
Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate…
- Trial name
- Alberta HEART (NCT02052804)
- Where
- 2 sites in Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Failure With Preserved Ejection Fraction, Obesity, Mild
Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction
Study Aim is creation of the Hospital Register of patients with heart failure with preserved ejection fraction (HFpEF) for a comprehensive assessment of the influence of gender characteristics, clinical and anamnestic factors…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Obesity, Mild, Decompensated Heart Failure
- Trial name
- NCT06114498
- Testing
- Echocardiography, Bioimpedance, Immunoassay
- Where
- 2 sites in Russia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Heart Failure With Preserved Ejection Fraction (HFPEF)
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases.
- Trial name
- SENSORFIT-4HEA (NCT07251361)
- Testing
- Supervised training
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Heart Failure, Atherosclerosis
The "ABCDE" Score as a Five-step Vascular Ultrasound Examination in Heart Failure
Heart failure (HF) is a clinical syndrome caused by structural and/or functional cardiac abnormalities, resulting in a reduced cardiac output and/or elevated intra-cardiac pressures at rest or during stress.
- Trial name
- NCT03771209
- Testing
- ultrasound examination
- Where
- Italy
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure, Heart Failure With Reduced Ejection Fraction
Electronic S3 Prediction of Hospital Readmissions for HF Exacerbation
The study objective is to measure the value of the third heart sound (S3) for the prediction of recurrent heart failure (HF). For the purpose of this study, a heart failure event will be defined as a hospitalization with a…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT04112849
- Testing
- Measurement of S3 heart sound
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy
UTSW HP [13-C] Pyruvate Injection in HCM
The study objective is to identify the earliest changes in energy substrate metabolism in patients with cardiomyopathies (CMP). To achieve this objective, we plan first to test the hypothesis that patients with CMP present focal…
- Conditions
- Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy, Duchenne Muscular Dystrophy, Cardiac Sarcoidosis
- Trial name
- HPHCM (NCT03057002)
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Kidney Diseases, Left Ventricular Systolic Dysfunction
Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography
The goal of this observational study is to learn about the value of multimodal ultrasound in early detection of left ventricular systolic dysfunction in patients with chronic kidney disease(CKD).
- Trial name
- NCT06221891
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Heart Failure, Ischemic Cardiomyopathy
Molecular Pathways of Cardiac Remodellation in Patients With Acute and Chronic Left Ventricular Disfunction
Chronic heart failure represents an extremely complex clinical syndrome, defined as the inability of the heart muscle to generate a volume adequate to the metabolic needs of peripheral tissues, or to do so only in the face of…
- Trial name
- HFrEF (NCT05745571)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Heart Failure With Preserved Ejection Fraction, Healthy
Understanding the Mechanisms of Diastolic Dysfunction
Heart failure is a clinical syndrome marked by breathlessness, even at low levels of exertion, general fatigue, and fluid retention and is estimated to affect 5.1 million people in the United States.
- Trial name
- NCT03340233
- Testing
- MRI (cardiac) off-label use gadolinium contrast (IND exempt), MRI (cardiac)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Heart Failure With Preserved Ejection Fraction
Ventricular-Vascular Coupling in Heart Failure
This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e.
- Trial name
- NCT00207220
- Testing
- arterial tonometry, echocardiography
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Failure With Preserved Ejection Fraction (HFpEF), Atrial Fibrillation
Intracranial Pressure and a Potential Vicious Circle of Atrial Fibrillation in HFpEF
This study was designed to investigate predictors of atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF), with a particular focus on the potential relationship between venous…
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFpEF), Atrial Fibrillation, Optic Nerve Sheath Diameter, Intracranial Pressure
- Trial name
- heart failure (NCT07521293)
- Testing
- Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Cardiac Function in Young Athletes
Study to Assess the Effect of OXYJUN on Ejection Fraction and Markers of Cardiovascular Injury
Young athletes are usually regarded as a special subgroup of healthy individuals with a unique lifestyle who are apparently invulnerable and often capable of extraordinary physical achievement.
- Trial name
- Enduoxy (NCT02207101)
- Testing
- E-OJ-01 (OXYJUN)
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Heart Failure, Heart Failure With Preserved Ejection Fraction
PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study
This is a prospective multicenter study to decipher phenotypic variability within patients with heart failure and preserved left ventricular ejection fraction (HFpEF).
- Trial name
- NCT04189029
- Testing
- Extensive phenotyping
- Where
- France
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris