Clinical trials: Ejection Fraction
Heart Failure With Preserved Ejection Fraction
Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction
Heart failure (HF) affects 2-3% of the population, and is characterized by impaired sodium balance which results in fluid overload.
- Trial name
- ERES-HFpEF (NCT03837470)
- Testing
- 0.9% Sodium Chloride, Furosemide 40 mg
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Adhish Agarwal
Heart Failure, Sarcopenia
The Sarcopenia Study
The goal of this cross-sectional study is to investigate the prevalence of sarcopenia in patients with Heart Failure. The main question it aims to answer is: Whether there is a difference in the prevalence of sarcopenia across…
- Conditions
- Heart Failure, Sarcopenia, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05888688
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Left-sided Congestive Heart Failure
Collagen Markers in Heart Failure and Preserved Ejection Fraction
Assessment of cardiac fibrosis by echocardiography (Speckle tracking), IRM (late-enhancement imaging), biology (markers of collagen turn-over) and proteomics
- Trial name
- COLLAG4 (NCT01677494)
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Heart Failure, Heart Failure With Preserved Ejection Fraction
Frequency and Magnitude of Subclinical Systolic Dysfunction by Strain Imaging in Heart Failure With Preserved Ejection Fraction
Background: Originally thought to be purely due to LV diastolic dysfunction, studies in western countries have suggested that heart failure with preserved ejection fraction (HFpEF) is more complex.
- Trial name
- NCT04163861
- Testing
- 2d speckle tracking echocardiography, serum BNP level
- Where
- Bangladesh
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Heart Failure With Preserved Ejection Fraction
Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
- Trial name
- NCT05839028
- Where
- Russia
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Failure, Heart Failure With Reduced Ejection Fraction
Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips
Assessing the Efficacy of Artificial Intelligence in Left Ventricular Function Screening Using Parasternal Long Axis View Cardiac Ultrasound Video Clips ABSTRACT BACKGROUND: Echocardiography serves as a fundamental diagnostic…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Cardiac Failure, Echocardiography
- Trial name
- NCT06330103
- Testing
- Easy EF
- Where
- Thailand
- Volunteers
- 923 people, healthy volunteers welcome
- Sponsor
- Rayong Hospital
Heart Failure, Diastolic
CoQ10 and D-ribose in Patients With Diastolic Heart Failure
The purpose of this study is to compare the clinical benefits of CoQ10 and D-ribose taken by patients who have diastolic heart failure, or heart failure with preserved ejection fraction (HFpEF).
- Trial name
- NCT03133793
- Testing
- CoQ10, D-Ribose Oral Powder
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Chronic Heart Failure
Prediabetes and Newly Diagnosed Diabetes in Chronic Heart Failure
The aim the study is to determine the prevalence of prediabetic dysglycemia and newly diagnosed diabetes among individuals with CHF(chronic heart failure) in sohag university hospital patients .
- Trial name
- NCT05090202
- Testing
- hbA1C
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
MRI Scans
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
This study's main specific aims are; 1. To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion…
- Trial name
- NCT04600115
- Testing
- Adenosine, Regadenoson, O-15 labeled radioactive water
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Utah
Heart Failure
A Study to Assess the Reaction of Body for Four Different Formulations of AZD9977 (Part A) and Influence of Food and Lower Dose of a Selected Formulation (Part B) in Healthy Male Subjects
AZD9977 is an oral, selective mineralocorticoid receptor (MR) modulator. AZD9977 is a partial antagonist and partial agonist in reporter gene assays and has a different interaction pattern with the MR compared to eplerenone.
- Trial name
- NCT03804645
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure With Normal Ejection Fraction
The Heart Failure With Preserved Ejection Fraction (HFpEF) Pathophysiology Study.
The study addresses the hypothesis that a gradual build-up in arterial resistance and microvascular endothelial dysfunction due to common comorbidities such as hypertension and diabetes mellitus, on top of age related vascular…
- Trial name
- IDENTIFY-HF (NCT03186833)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Heart Failure, Heart Failure With Preserved Ejection Fraction
Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure
This is a study of the DASH diet (Dietary Approaches to Stop Hypertension) in the exploration of effective strategies for Heart failure (HF) with preserved ejection fraction (HFPEF) prevention.
- Trial name
- DASHF (NCT04113291)
- Testing
- DASH Diet, Usual diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pulmonary; Hypertension, Heart Failure
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown…
- Conditions
- Pulmonary; Hypertension, Heart Failure, Preserved Ejection Fraction
- Trial name
- PMED (NCT02980068)
- Testing
- 15N Nitrate, 14N Nitrate
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Heart Failure With Preserved Ejection Fraction, Hypertension
Clinical Significance and Diagnosis of Sarcopenia in Cardiac Patients
Obesity sarcopenia, characterized by the coexistence of excess fat and muscle mass reduction, may contribute to the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertension, Sarcopenic Obesity
- Trial name
- NCT04175080
- Where
- Poland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Cardiac Disease
PROSPECTIVE EVALUATION OF HEARTFOCUS
The study's objective is to evaluate if exams, performed with the HeartFocus software by novices, are of sufficient quality to visually analyze the left ventricular size, the left ventricular function, the right ventricular size…
- Trial name
- HF-01 (NCT05874128)
- Testing
- Using HeartFocus software with AI guidance (Novices), Using HeartFocus software without AI-guidance
- Where
- 2 sites in United States, France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- DESKi
Chest Pain, Shortness of Breath
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart…
- Trial name
- NCT06927973
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure
Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate…
- Trial name
- Alberta HEART (NCT02052804)
- Where
- 2 sites in Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy Volunteers
A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects
This study will evaluate pharmacokinetics (PK) of four different formulations with different release profiles of AZD9977 (PART A) in the fasted state, and one of the formulation will be selected for further development (Part B).
- Trial name
- NCT03450759
- Testing
- AZD9977 Oral suspension (reference), AZD9977 capsule, AZD9977 ER capsule (fastvrate)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
HFpEF - Heart Failure With Preserved Ejection Fraction
Serum IGF1 on Female HFpEF Patients
Study Title: Application of Serum IGF1 in the Diagnosis of Female Heart Failure with Preserved Ejection Fraction (HFpEF) Study Institution: Hong Kong University-Shenzhen Hospital Principal Investigator: Sidong Cai 1.
- Trial name
- IGF1 (NCT07015554)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Heart Failure, Congestive
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a
Heart failure with preserved ejection fraction or HFpEF, represents nearly 50% of all heart failure cases and is particularly common in the elderly. The disease has no current treatment options.
- Trial name
- NCT02772068
- Testing
- Istaroxime, Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Benjamin Levine