Clinical trials: Ejection Fraction
Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may…
- Conditions
- Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction
- Trial name
- PREFER-HF (NCT03480633)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure
Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction
A randomized, double-blinded, placebo-controlled crossover study to assess effect of isosorbide mononitrate with dose up-titration on activity tolerance as assessed by (hip-worn, tri-axial) accelerometry.
- Trial name
- NEAT-HFpeF (NCT02053493)
- Testing
- Isosorbide Mononitrate
- Where
- 22 sites in United States
- Volunteers
- 110 people
- Sponsor
- Adrian Hernandez
MASH - Metabolic Dysfunction-Associated Steatohepatitis, Heart Failure With Preserved Ejection Fraction (HFPEF)
Resmetirom in Patients With MASH and HFpEF
This Phase 1b multicenter randomized double-blind placebo-controlled study evaluates the safety, tolerability and hepatic pharmacodynamic effects of resmetirom in adults with metabolic dysfunction-associated steatohepatitis…
- Trial name
- NCT07830758
- Testing
- Resmetirom
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Ferric Carboxymaltose, Heart Failure With Reduced Ejection Fraction
Iron Intravenous Therapy in Reducing the Burden of Severe Arrhythmias in Heart Failure With Reduced Ejection Fraction
An open label,single-center, non-interventional prospective study with the aim on investigating the effect of intravenous ferric carboxymaltose in restoring iron status and reducing the risk of severe arrhythmic events in…
- Conditions
- Ferric Carboxymaltose, Heart Failure With Reduced Ejection Fraction, Arrhythmias, Cardiac
- Trial name
- RESAFE (NCT04974021)
- Testing
- Ferric carboxymaltose
- Where
- Greece
- Volunteers
- 106 people
- Sponsor
- Aristotle University Of Thessaloniki
Heart Failure With Preserved Ejection Fraction (HFPEF), Left Ventricular End Diastolic Pressure (LVEDP)
Evaluation of Left Ventricular Filling Pressures During Exercise
Heart failure with preserved ejection fraction (HFPEF) is common and is a real public health issue. Diagnosis, especially when there are no congestive signs, is difficult.
- Trial name
- PREFFORT (NCT01714752)
- Testing
- measure of left ventricular and diastolic pressure at exercise
- Where
- France
- Volunteers
- 60 people
- Sponsor
- French Cardiology Society
Heart Failure With Reduced Ejection Fraction
Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Risk Stratification
A number of large randomized studies have demonstrated the importance of left ventricle ejection fraction (LV EF) for ventrucular tachyarhrythmia's (VT) prediction.
- Trial name
- PERFECT (NCT05539898)
- Testing
- ICD implantation
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- Astrakhan Federal Centre For Cardiac Surgery
Cardiac Disease
The Effects of Neurophysiological Facilitation Techniques After Coronary Artery Bypass Graft Surgery
The aim of the study is to investigate the effects of neurophysiological facilitation techniques, applied in addition to Phase I cardiac rehabilitation in the early postoperative period after coronary artery bypass graft (CABG)…
- Trial name
- NCT06640699
- Testing
- exercise
- Volunteers
- 36 people
- Sponsor
- Istanbul University - Cerrahpasa
Mitral Regurgitation
Dutch-AMR: Early Mitral Valve Repair Versus Watchful Waiting in Asymptomatic Patients With Severe Mitral Regurgitation
Rationale: Severe asymptomatic organic Mitral Valve (MV) regurgitation with preserved left ventricular (LV) function is a challenging clinical entity as data on the recommended treatment strategy for these patients are scarce and…
- Trial name
- Dutch-AMR (NCT03975998)
- Testing
- Mitral valve repair
- Where
- 6 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- UMC Utrecht
Aortic Stenosis
Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis
Whether to intervene in asymptomatic patients with severe aortic stenosis and normal left ventricular ejection fraction remains controversial.
- Trial name
- AVATAR (NCT02436655)
- Testing
- surgical aortic valve replacement
- Where
- 14 sites in Belgium, Croatia and 7 more
- Volunteers
- 157 people
- Sponsor
- Clinical Centre of Serbia
Atrial Fibrillation
Spironolactone in Atrial Fibrillation
This study aims to assess whether treatment with a drug called spironolactone, which is an aldosterone inhibitor, can improve ability to cope with exertion, quality of life and ability of the heart to relax better in symptomatic…
- Trial name
- IMPRESS-AF (NCT02673463)
- Testing
- Spironolactone
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Birmingham
Heart Failure With Preserved Ejection Fraction (HFpEF)
Characteristics, Phenotypes, and TRAITS of Heart Failure With Preserved Ejection Fraction (TRAITS-HFpEF)
Heart failure with preserved ejection fraction (HFpEF), a certain type of heart failure, occurs when the heart doesn't pump blood around the body properly. It can cause breathlessness, tiredness, and swollen feet or ankles.
- Trial name
- TRAITS-HFpEF (NCT05383287)
- Where
- United Kingdom
- Volunteers
- 1,250 people
- Sponsor
- Manchester University NHS Foundation Trust
Heart Disease, Heart Failure
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
Heart failure (HF) is a global public health issue that affects more than 63 million people worldwide. The clinical and economic burden of HF on health care systems is substantial.
- Conditions
- Heart Disease, Heart Failure, Cardiovascular Disease, Heart Failure, Systolic
- Trial name
- PHRASE-HF (NCT06675552)
- Where
- 6 sites in Germany
- Volunteers
- 338 people
- Sponsor
- AstraZeneca
Heart Failure, Diastolic
Physiologic Accelerated Pacing as a Treatment in Patients With Heart Failure With Preserved Ejection Fraction
Part I: Week 0-12: Quantify the effects of lower heart rate (HR) elevation on symptoms and function in patients with heart failure with preserved ejection fraction (HFpEF).
- Trial name
- PACE HFpEF (NCT04546555)
- Testing
- Dual chamber pacemaker, Accelerated Physiologic Pacing, Nocturnal Pacing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Daniel L Lustgarten
Heart Failure With Left Ventricular Ejection Fraction Greater Than or Equal to 40 Per Cent, Healthy Volunteers
A Study to Compare How Much of the Study Treatment Finerenone Gets Into the Blood When the Same Amount is Taken in One and in Two Tablets of Different Strengths in Healthy Male Participants
In this bioequivalence study, healthy male participants took the study treatment finerenone in the form of one and two tablets of different strengths by mouth.
- Trial name
- NCT07116512
- Testing
- Finerenone (BAY94-8862): intervention A, Finerenone (BAY94-8862): intervention B
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bayer
Heart Failure, Ejection Fraction
Tapering Heart Failure Medication in Patients With Heart Failure With Recovered Ejection Fraction; Open Label Prospective Random Trial
Study start date is on Nov 27th 2024. A patient with an initial ejection fraction (EF) of less than 40%, whose follow-up shows an improvement to an EF of 50% or higher, along with the left ventricular end-diastolic diameter…
- Conditions
- Heart Failure, Ejection Fraction, Recovery of Function
- Trial name
- HFrecEF (NCT06724653)
- Testing
- RAS blocker tapering group, Beta blocker tapering out
- Where
- 2 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- Chungnam National University Hospital
Heart Failure With Reduced Ejection Fraction
Exercise and NO in HFrEF
Heart disease is the leading cause of death in the United States, accounting for one in every four deaths in 2010 and costing over $300 billion annually in health care, medication, and lost productivity.
- Trial name
- NCT03136029
- Testing
- Antioxidant, Tetrahydrobiopterin (BH4), Exercise training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- VA Office of Research and Development
Heart Failure and Preserved Ejection Fraction, Atrial Fibrillation (AF)
Finerenone's Impact on Cardiac Electrical Stability in HFpEF
To evaluate the efficacy of finerenone in reducing the incidence of any electrical instability or arrhythmias in the form of new-onset atrial fibrillation or atrial flutter (AFF), atrial tachycardia, extrasystoles (premature…
- Conditions
- Heart Failure and Preserved Ejection Fraction, Atrial Fibrillation (AF), Arrythmia
- Trial name
- NCT07866287
- Testing
- Finerenone
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Heart Failure With Reduced Ejection Fraction
Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.
The purpose of the study was to determine the effect of LCZ696 vs. enalapril on improvement of exercise capacity in patients with chronic heart failure with reduced ejection fraction.
- Trial name
- NCT02768298
- Testing
- LCZ696, Enalapril
- Where
- 34 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Analysis of Cardiac Biomarker Racial Discrepancies
The goal is to review cardiac biomarkers present on admission between African American patients with new onset Heart Failure compared to a comparable cohort of Caucasian patients to establish whether there is a clinically…
- Trial name
- NCT05224557
- Testing
- No intervention
- Where
- United States
- Sponsor
- Methodist Health System
Heart Failure
Efficacy and Safety of Xinyue Capsule in the Treatment of Heart Failure With Preserved Ejection Fraction
The purpose of this study is to evaluate the effect of Xinyue Capsule in the improvement cardiac function and reduction the level of heart failure biomarker NT-proBNP in patients suffering from HF with an ejection fraction…
- Trial name
- NCT06946095
- Testing
- Chinese patent medicine
- Volunteers
- 246 people
- Sponsor
- Beijing Anzhen Hospital
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