Clinical trials: Ejection Fraction
Heart Failure Acute, Heart Failure
Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University…
- Conditions
- Heart Failure Acute, Heart Failure, Echocardiography
- Trial name
- STRATS-AHF (NCT03513653)
- Testing
- Echocardiography with speckle-tracking imaging
- Where
- 3 sites in South Korea
- Volunteers
- 4,312 people
- Sponsor
- Seoul National University Hospital
Heart Failure and Reduced Ejection Fraction
Developing a Digital Aid to Improve ICD Decisions
Advanced heart failure, affecting 7 million Americans, has multiple causes and results in greatly increased risk of disability and death.
- Trial name
- NCT07084142
- Testing
- Online, patient-facing decision-making aid (app) with personalized risk information., Implantable Cardioverter Defibrillator (ICD), Online, patient-facing decision-making app without personalized risk information.
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Stanford University
Left Ventricular Dysfunction, Quality of Recovery
Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery
A randomized, controlled, double-blinded clinical trial evaluating the effect of the administration of a Maltodextrin solution on cardiac function in patients presenting for coronary artery bypass grafting surgery with a reduced…
- Conditions
- Left Ventricular Dysfunction, Quality of Recovery, Right Ventricular Dysfunction
- Trial name
- NCT05188222
- Testing
- Maltodextrin solution
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Jewish General Hospital
Iron Deficiency, Heart Failure With Reduced Ejection Fraction
Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction
A significant percentage of patients with heart failure and reduced ejection fraction (HFrEF) or mildly reduced ejection fraction (HFmrEF) have iron deficiency who are symptomatic.
- Conditions
- Iron Deficiency, Heart Failure With Reduced Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction
- Trial name
- NCT05992116
- Where
- Jordan
- Volunteers
- 450 people
- Sponsor
- Jordan Collaborating Cardiology Group
Type 2 Diabetes Mellitus (T2DM), Chronic Heart Failure (CHF)
Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction.
Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction--a multicenter randomized controlled study.
- Trial name
- GLID-HF (NCT07288749)
- Testing
- Glimepiride (oral)
- Where
- China
- Volunteers
- 1,484 people
- Sponsor
- Tongji Hospital
Myocardial Infarction, Autonomic Nervous System Diseases
Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction
The majority of deaths after myocardial infarction occurs in patients with preserved left ventricular ejection fraction (>35%) for whom no prophylactic strategies exist.
- Trial name
- SMART-MI (NCT02594488)
- Testing
- Medtronic Reveal LINQ implantable cardiac monitor
- Where
- 32 sites in Austria, Germany
- Volunteers
- 400 people
- Sponsor
- LMU Klinikum
Heart Failure With Normal Ejection Fraction
Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of HFpEF
Heart failure (HF) with preserved ejection fraction (HFpEF) has become the most prevalent form of HF in developed countries. Despite its increasing in prevalence, there is no evidence-based effective therapy for HFpEF The purpose…
- Trial name
- TRAINING-HF (NCT02638961)
- Testing
- IMT, FES, Standard treatment
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Universitat Jaume I
Aortic Valve Stenosis
Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis
Background: Aortic valve stenosis is a disease that makes a major heart valve get smaller. This reduces heart function and causes death.
- Trial name
- NCT01905852
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure With Preserved Ejection Fraction, Obesity
PErirenal Adipose Tissue and RenaL Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction
Rationale: Perirenal adipose tissue (PRAT) thickness has been associated to worsening renal function and hypertension. The role of PRAT in heart failure with a preserved ejection fraction (HFpEF) has never been established.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Obesity, Renal Insufficiency
- Trial name
- PEARL-HFPEF (NCT05219188)
- Testing
- 3.7 mS, CT radiation
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Heart Failure
Pulmonary REsistance Modification Under Treatment With Sacubitril/valsartaN in paTients With Heart Failure With Reduced Ejection Fraction
MAIN OBJECTIVE. Demonstration that use of sacubitril/valsartan influences parameters of right heart catheterization, including pulmonary artery pressure, and provokes changes in pulmonary circulation resistance in patients with…
- Trial name
- PRESENT-HF (NCT05487261)
- Testing
- Sacubitril-valsartan, Enalapril
- Where
- 5 sites in Poland
- Volunteers
- 260 people
- Sponsor
- Clinical Hospital Heliodor Swiecicki of the Medical University of Karol Marcinkowski in Poznań
Heart Failure With Preserved Ejection Fraction
Risk Factors In Heart Failure Patients With Preserved Ejection Fraction
This study aimed to identify the independent risk factors associated with heart failure readmission, cardiac mortality and all-cause death among patients discharged from Xiangtan Central Hospital with heart failure and preserved…
- Trial name
- RIPE-HF (NCT06487468)
- Volunteers
- 9,419 people
- Sponsor
- Xiangtan Central Hospital
Heart Failure With Reduced Ejection Fraction, Congestion
ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF
The overall hypothesis is that treatment with the SGLT2 inhibitor Ertugliflozin induces a differential regulation in interstitial fluid vs plasma volume, with more reduction of the volume from the interstitial fluid than from the…
- Trial name
- ERTU-SODIUM (NCT05152940)
- Testing
- Ertugliflozin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
ST-Elevation Myocardial Infarction (STEMI), Heart Failure With Preserved Ejection Fraction (HFpEF)
Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis
An observational, cross-sectional, longitudinal, microdosing Position Emission Tomography (PET) imaging study to investigate platelet derived growth factor receptor beta (PDGFRß) expression in the heart of patients with high or…
- Trial name
- PARIS (NCT06956560)
- Testing
- PET/MRI or separate PET/CT and MRI
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction (HFPEF)
AI-based Echocardiography for Detection of Cardiac Amyloidosis
Cardiac amyloidosis is characterized by deposition of misfolded protein in the myocardium causing mainly heart failure symptoms with preserved left ventricular ejection fraction.
- Conditions
- Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction (HFPEF), Left Ventricular Hypertrophy
- Trial name
- ORCHESTRA (NCT07529860)
- Testing
- AI-based echocardiogram
- Volunteers
- 200 people
- Sponsor
- Germans Trias i Pujol Hospital
Angioscintigraphy, Tomoscintigraphy
Determination of Left Ventricular Ejection Fraction Using Cardiac Angioscintigraphy
The purpose is to determine whether measurements of left ventricular ejection fraction (LVEF) obtained with angiographies recorded by conventional Anger camera or D-SPECT camera are equivalent.
- Trial name
- FEVED (NCT02869308)
- Testing
- stannous pyrophosphate, Technetium-99m, E-CAM Camera
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure，Congestive
Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)
The investigators sought to evaluate the effectiveness of treatment with furosemide + HSS in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated…
- Trial name
- NCT04628325
- Testing
- Furosemide
- Where
- 2 sites in Italy
- Volunteers
- 136 people
- Sponsor
- University of Palermo
Anemia
Anemia in Heart Failure With a Preserved Ejection Fraction (HFPEF)
The purpose of this study is to determine if treating anemia with subcutaneous erythropoetin in patients with heart failure and a preserved ejection fraction (HFPEF) will be associated with reverse ventricular remodeling…
- Trial name
- NCT00286182
- Testing
- Erythropoietin alpha
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Mathew S. Maurer
Heart Failure, Cardiac Failure
A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function
The purpose of this study is to evaluate the effects of BMS-986231 on systolic and diastolic parameters in patients with heart failure and low ejection fraction.
- Conditions
- Heart Failure, Cardiac Failure, Reduced Ventricular Ejection Fraction
- Trial name
- NCT03357731
- Testing
- HNO Donor, Nitroglycerin (NTG)
- Where
- 18 sites in United States, Japan and 2 more
- Volunteers
- 49 people
- Sponsor
- Bristol-Myers Squibb
Heart Failure
Real World Experience in Heart Failure With Reduced Ejection Fraction (HFrEF) Patients Treated With sAc/vaL.
The study is a cohort observational, retrospective, non-interventional study.
- Trial name
- NCT05448872
- Testing
- Sacubitril/Valsartan
- Where
- Italy
- Volunteers
- 924 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure With Preserved Ejection Fraction, Remote Monitoring in Heart Failure
Managing Congestion in Heart Failure: A Mechanistic Study in Patients With HFpEF
The goal of this clinical trial (MAGIC-HF) is to understand whether daily remote monitoring of pulmonary artery pressure using the CardioMEMS™ device and body water levels using a smart scale can improve the management of…
- Trial name
- MAGIC-HF (NCT06977477)
- Testing
- Remote Monitoring for Congestion Management in HFpEF Patients
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Otto-von-Guericke University Magdeburg
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