Clinical trials: Elder
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Depression, Anxiety
Positive Minds Strong Bodies Implementation
This study aims to address treatment and service disparities and prevent disability among racial/ethnic and linguistic minority elders.
- Conditions
- Depression, Anxiety, Physical Disability
- Trial name
- PMSB-E (NCT04545593)
- Testing
- Positive Minds Strong Bodies Enhanced, Enhanced Usual Care
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- Massachusetts General Hospital
Sedentary Lifestyle, Risk of Disability
The LIFE Study - Lifestyle Interventions and Independence for Elders
Based upon promising results from a pilot study among 424 sedentary older adults who were randomized to a physical activity intervention or a successful aging health education intervention, a Phase 3 multi-center randomized…
- Conditions
- Sedentary Lifestyle, Risk of Disability, Aging
- Trial name
- LIFE (NCT01072500)
- Testing
- Physical Activity, Successful Aging
- Where
- 8 sites in United States
- Volunteers
- 1,635 people
- Sponsor
- University of Florida
Vitamin D Deficiency, Accidental Falls
Improving Vitamin D Status in Home-bound Elders
In the past two decades, the role of vitamin D has extended beyond bone health to encompass a wide range of biological activities important to physical function in older adults.
- Trial name
- MOW VitD (NCT01410084)
- Testing
- Vitamin D3, Vitamin E
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Wake Forest University Health Sciences
Pneumococcal Infections
Immunogenicity and Reactogenicity of Pneumococcal Polysaccharide and Conjugate Vaccines in Native Elders
To test the hypothesis that immune responses to 23-valent pneumococcal polysaccharide vaccine (PPV-23) could be improved in Alaska Native elders by immune priming with 7-valent pneumococcal conjugate vaccine (PCV-7), we assessed…
- Trial name
- NCT00153543
- Testing
- PCV7 + PPV23, 2 months, PCV7 + PPV23, 6 months
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Mild Cognitive Impairment
Lithium As a Treatment to Prevent Impairment of Cognition in Elders
Alzheimer's disease (AD) is the most common cause of dementia in adults 65 years and older. AD leads to a complete loss of memory and independent function, and presently there is no cure.
- Trial name
- LATTICE (NCT03185208)
- Testing
- Lithium Carbonate
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Ariel Gildengers, MD
Dementia
PLAN: Dementia Literacy Education and Navigation for Korean Elders With Probable Dementia and Their Caregivers
Early detection of dementia allows for a transition to early dementia care that may delay or slow deterioration of cognitive functions and functional disabilities and enable families to adequately plan for the potential…
- Trial name
- PLAN (NCT03909347)
- Testing
- PLAN, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 574 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoporosis, Bone Loss
Zoledronic Acid for Osteoporosis in the Elderly
This trial will examine the safety, efficacy and feasibility of a single dose of intravenous zoledronic acid in the maintenance of skeletal integrity for frail, institutionalized women, who are most at risk for the deleterious…
- Conditions
- Osteoporosis, Bone Loss, Fragility Fractures
- Trial name
- ZEST (NCT00558012)
- Testing
- Intravenous zoledronic acid, Vitamin D 800 IU/daily, Calcium 1200 mg/daily
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Elder Abuse
Feasibility of VOICES Elder Abuse Intervention in Primary Care Setting (VOICES-PC Feasibility)
To test an interactive intervention to screen for Elder Abuse and Mistreatment (EM) in the Primary Care (PC) setting to promote self-identification and self-disclosure of EM.
- Trial name
- VOICES-PC (NCT05224843)
- Testing
- Virtual cOaching in making Informed Choices on Elder Mistreatment Self-Disclosure (VOICES)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer's Disease
Imaging Inflammation in Alzheimer's Disease
This study is being done to learn about inflammation and amyloid in Alzheimer's disease. A type of brain scan called a PET scan is used measure 1) inflammation and 2) abnormal accumulation of a the amount of a certain protein…
- Trial name
- NCT02831283
- Testing
- 11C-PBR28, 18F-Florbetaben, Lumbar puncture (optional)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Mitochondrial Function, Physical Function
Resveratrol to Enhance Vitality and Vigor in Elders
Resveratrol, a compound found in red wine and dark-skinned grapes, will improve the function of mitochondria (energy producing components) within the leg muscles of moderate functioning older adults.
- Trial name
- REVIVE (NCT02123121)
- Testing
- Resveratrol 1000 mg/day, Resveratrol 1500 mg/day, Vegetable cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Elder Abuse, Elder Mistreatment
Feasibility of Elder Mistreatment VOICES-CI Screening Tool
The aim of this study is to assess the feasibility of the VOICES Elder Abuse Intervention among older adults with cognitive impairment.
- Trial name
- VOICES-CI (NCT05216081)
- Testing
- Virtual cOaching in making Informed Choices on Elder Mistreatment Self-Disclosure (VOICES)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Yale University
Assisted Living, Resident to Resident Elder Mistreatment
Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living
Resident-to-resident elder mistreatment (R-REM) is a significant problem in long-term services and support settings (LTSS), and likely to cause physical and or psychological distress.
- Trial name
- NCT03383289
- Testing
- R-REM training
- Where
- United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Hebrew Home at Riverdale
Dementia, Caregiver Burden
Knowledge and Interpersonal Skills to Develop Exemplary Relationships (KINDER): Pilot Study
The purpose of this study is to determine the feasibility and acceptability of delivering the KINDER intervention to family caregivers to persons living with dementia.
- Conditions
- Dementia, Caregiver Burden, Relation, Family, Elder Abuse
- Trial name
- KINDER (NCT05783102)
- Testing
- Knowledge and Interpersonal Skills to Develop Exemplary Relationships
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Flu Vaccine
Senescent Immunity in Elders and Vaccine Responses (SILVER)
To study the effects of age on the immune system's response to flu vaccine and to study the connection between the immune system and physical and cognitive changes associated with aging.
- Trial name
- NCT04077424
- Testing
- Fluzone-High Dose Quadrivalent, Fluad, Flublock
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chronic Musculoskeletal Pain
Krill Oil for Pain in Elders
Chronic musculoskeletal pain contributes to mobility disability among older adults. Nutritional interventions, like omega-3 fatty acids, may help manage pain and improve physical function.
- Trial name
- KOPE (NCT06580912)
- Testing
- Krill oil, Mixed vegetable oil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Influenza
Intradermal Influenza Vaccine Study in Elders
This randomized trial compared the immunogenicity of 60% dose intradermal (ID) influenza vaccination to standard intramuscular (IM) vaccination of full-dose or 60% dose vaccine.
- Trial name
- NCT00504231
- Testing
- Fluzone Influenza Vaccine (2007-2008)
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- PATH
Arterial Stiffness, Inflammation
Bioactive Compounds in Watermelon Modulating Oxidative Stress and Inflammation in Elders
Watermelon is the only food with a unique combination of amino acids and antioxidants that may reduce artery stiffness. However, only 27% of older adults meet the daily recommendation for fruit intake.
- Trial name
- MOXIE (NCT03626168)
- Testing
- 100% watermelon juice
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Sense of Community
Community Spirit in Residence for the Elderly
The objective of our study is to observe and understand factors that emphasizes the creation of a community spirit. Specific objectives: 1.
- Trial name
- 437_EsCom (NCT06441877)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- TOPMED
Osteoarthritis (OA)
Effect of Chair Yoga on Elders With Osteoarthritis
The current study is a two-arm randomized controlled clinical trial to test the feasibility of recruiting, randomizing, and having older adults with osteoarthritis (OA) adhere to and safely complete the 8-week Sit 'N' Fit Chair…
- Trial name
- NCT02113410
- Testing
- Sit 'N' Fit Chair Yoga (SNFCY), Health Education Program (HEP)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Florida Atlantic University