Clinical trials: Elderly Cancer Patients
Chronic Lymphocytic Leukemia
Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy, such as fludarabine and chlorambucil, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00262795
- Testing
- Fludarabine, Chlorambucil
- Where
- 88 sites in Austria, Germany
- Volunteers
- 206 people
- Sponsor
- German CLL Study Group
Acute Myeloid Leukemia
TBF Conditioning Regimen for Haploidentical Stem Cell Transplantation in Elderly AML Patients in First Complete Remission
Acute myeloid leukemia (AML) is a serious blood cancer that mainly affects older adults. For patients who achieve their first complete remission (CR1), allogeneic hematopoietic stem cell transplantation (HSCT) may provide a…
- Trial name
- TBF-AML (NCT07563920)
- Testing
- Thiotepa, Busulfan (BU), Fludarabine
- Volunteers
- 93 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cancer, Older Adults
Comprehensive Health Assessment for my Cancer Treatment Plan
Geriatric assessment (GA) predicts treatment toxicity and overall mortality in older adults with cancer. To improve treatment decision making in older adults with cancer, the American Society of Clinical Oncology (ASCO) and the…
- Trial name
- CHAMP-F (NCT05499975)
- Testing
- Self-reported online geriatric assessment (CHAMP)
- Where
- 3 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia
Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy
This phase II trial studies how well eltrombopag olamine works in improving the recovery of platelet counts in older patients with Acute Myeloid Leukemia (AML) undergoing induction (the first treatment given for a disease)…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
- Trial name
- NCT02071901
- Testing
- eltrombopag olamine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Case Comprehensive Cancer Center
Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy
LIVELUNG - Impact of CGA in Patients Diagnosed With Localized NSCLC Treated With SBRT
Older patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT) often die from other causes than lung cancer due to age-related comorbidities.
- Conditions
- Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy, Comprehensive Geriatric Assessment
- Trial name
- LIVELUNG (NCT05919641)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 4 sites in Denmark
- Volunteers
- 130 people
- Sponsor
- Odense University Hospital
Solid Tumors
Study to Evaluate the Effect of Age (Geriatric) and Kidney Function on the Safety, Efficacy and Pharmacokinetics of OctreoScan in Patients Who Have New or Recurrent Tumors
The objective of this study was to evaluate the effect of age (geriatric) and renal function on the safety, efficacy and pharmacokinetics of OctreoScan at the recommended clinical dose in this patient population.
- Trial name
- NCT00944372
- Testing
- Indium In-111 pentetreotide
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Mallinckrodt
Esophageal Cancer, Radiation Therapy
Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy
The goal of this clinical trial is to explore the therapeutic efficacy of immune checkpoint inhibitors combined with radical radiotherapy in elderly patients with esophageal cancer.
- Conditions
- Esophageal Cancer, Radiation Therapy, Immunotherapy, Chemotherapy
- Trial name
- NCT05817201
- Testing
- Toripalimab, Tegafur, IMRT
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Prostate Cancer, Radiotherapy Side Effect
Hypofractionated Radiotherapy in Prostate Cancer Patients Aged 75 Years or Older.
The majority of all new prostate cancer cases are diagnosed in men aged > 70 years, with the highest incidence in men aged > 90 years.
- Trial name
- NCT04535908
- Testing
- Hypofractionated radiotherapy
- Where
- Austria
- Volunteers
- 23 people
- Sponsor
- Medical University of Graz
Sarcopenia, Gastrointestinal Neoplasms
Preoperative Sarcopenia and Postoperative Outcomes in Older Patients With Gastrointestinal Cancer
This prospective cohort study aims to evaluate the association between preoperative sarcopenia and postoperative outcomes in patients aged 60 years or older undergoing elective surgery for gastrointestinal cancer.
- Trial name
- NCT07817758
- Testing
- Preoperative Sarcopenia Status
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Glioblastoma
Biopsy Versus Resection in Elderly Glioblastoma Patients. A Prospective Cohort Study.
This trial is set up as a prospective observational cohort study to identify if either biopsy or resection should be the surgical modality of choice in elderly glioblastoma patients with a newly diagnosed tumor.
- Trial name
- BIOPSY (NCT05641220)
- Where
- 6 sites in Netherlands
- Volunteers
- 325 people
- Sponsor
- Erasmus Medical Center
Acute Myeloid Leukemia
Elderly Patients With Acute Myeloid Leukemia (AML), Maintenance Phase After Complete Remission (CR)
Phase II Multicentric Trial Open Label, Multicenter, randomized to evaluate the efficacy of a Maintenance Therapy in First Complete Remission After Induction for Elderly (≥ 60) Fit Patients With Poor Prognosis Acute Myeloid…
- Trial name
- NCT01301820
- Testing
- azacitidine, Lenalidomide
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Innovative Leukemia Organisation
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Acute Myeloid Leukemia (AML)
VABu Conditioning in Elderly AML HSCT
This is an open-label, multi-center, single-arm clinical study evaluating the efficacy and safety of the VABu conditioning regimen in elderly patients (≥60 years) with acute myeloid leukemia (AML) undergoing allogeneic…
- Trial name
- NCT07583888
- Testing
- VaBU
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Acute Myeloid Leukemia
GRASPA Treatment for Patients With Acute Myeloblastic Leukemia
The protocol aims at adding GRASPA (L-asparaginase encapsulated in red blood cells, eryaspase) to standard chemotherapy (low-dose cytarabine) to treat patients older than 65 years diagnosed with AML and unfit for intensive…
- Trial name
- ENFORCE (NCT01810705)
- Testing
- GRASPA
- Where
- 21 sites in France
- Volunteers
- 123 people
- Sponsor
- ERYtech Pharma
Esophageal Squamous Cell Carcinoma (ESCC)
An Observational Study on the Safety and Efficacy of Immunotherapy Combined With Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
Title: Observational Study on the Safety and Efficacy of Immunotherapy Combined with Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma Study Purpose: This single-center, open-label…
- Trial name
- NCT07080437
- Testing
- Immunotherapy Therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Three Gorges Hospital of Chongqing University
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)
The primary objective of this study is to evaluate the efficacy of subcutaneous azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in adults with previously untreated, higher risk MDS who…
- Trial name
- NCT02775903
- Testing
- Azacitidine, Durvalumab
- Where
- 103 sites in United States, Austria and 10 more
- Volunteers
- 213 people
- Sponsor
- Celgene
Head and Neck Cancer
Magnesium Sulphate and Rocuronium in Patients Over 60
The purpose of this study is to evaluate the effects of MgSO4 administration on the pharmacodynamics of rocuronium in patients with 60 or more years of age.
- Trial name
- NCT01804205
- Testing
- Magnesium Sulfate
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pedro Rotava
Hypotension, Urologic Neoplasms
Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients
Spinal anesthesia-induced hypotension is a common and clinically significant complication in elderly patients undergoing oncologic surgery.
- Conditions
- Hypotension, Urologic Neoplasms, Aged, Spinal Anesthesia
- Trial name
- NCT07481851
- Testing
- Skin Conductance Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
HNSCC, Oral Cavity Cancer
Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited.
- Conditions
- HNSCC, Oral Cavity Cancer, Oropharynx Cancer, Hypopharynx Cancer
- Trial name
- SENIOR (NCT05337631)
- Where
- 18 sites in United States, Cyprus and 3 more
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg
Multiple Myeloma
Melphalan, Prednisone, and CC-5013 (Revlimid) as Induction Therapy in Multiple Myeloma
The purpose of this study is to evaluate the safety and efficacy of the association of Melphalan/Prednisone/Revlimid (MPR) as induction treatment for newly diagnosed myeloma patients over age 65 or those under 65 years who refuse…
- Trial name
- NCT00396045
- Testing
- Revlimid (CC-5013)
- Where
- 9 sites in Italy
- Volunteers
- 54 people
- Sponsor
- University of Turin, Italy
Cancer
Predisposing Factors Associated With Chemotherapy Toxicity in Elderly Cancer Patients
These days, there is higher proportion of elderly cancer patients. Most of them have comorbidities, borderline performance status and nutritional status.
- Trial name
- NCT02317757
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Mahidol University
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