Clinical trials: Elderly Cancer Patients
Multiple Myeloma
Lenalidomide and Dexamethasone Versus Melphalan Prednisone and Lenalidomide Versus Cyclophosphamide, Prednisone and Lenalidomide in Elderly Multiple Myeloma Patients
This is a multicenter, randomized, controlled, 3 arm parallel group study designed to evaluate the efficacy and safety of three all-oral combinations: lenalidomide with dexamethasone (Rd) in comparison with lenalidomide in…
- Trial name
- NCT01093196
- Testing
- Melphalan, Prednisone, Lenalidomide, Cyclophosphamide, Prednisone, Lenalidomide, Lenalidomide, dexamethasone
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- Fondazione EMN Italy Onlus
Chronic Lymphocytic Leukemia
Rituximab and Alemtuzumab in Treating Older Patients With Progressive Chronic Lymphocytic Leukemia
RATIONALE: Monoclonal antibodies, such as rituximab and alemtuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT01013961
- Testing
- alemtuzumab, rituximab
- Where
- 102 sites in United States
- Volunteers
- 31 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Postoperative Delirium, Gastrointestinal Tumors
Opioid-free Anesthesia and Postoperative Delirium
Postoperative delirium (POD) is a common acute and transient form of brain dysfunction in elderly patients following surgery that can lead to serious adverse clinical outcomes and even death.
- Trial name
- NCT07603596
- Testing
- OFA group, OBA group
- Volunteers
- 174 people
- Sponsor
- Qianfoshan Hospital
Cancer
A Geriatric Assessment Intervention for Older Cancer Patients Receiving Chemotherapy
The purpose of this study is to determine whether information regarding GA and GA-driven interventions improves outcomes in older cancer patients receiving first-line or second-line chemotherapy by comparing rates of chemotherapy…
- Trial name
- NCT01915056
- Testing
- GA-driven Intervention
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Rochester
Brain Neoplasms, Delirium - Postoperative
Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients
This study will compare three anesthesia medicines used to put people into a deep sleep during surgery: ciprofol, propofol, and sevoflurane. All three are commonly used for general anesthesia, but they work in different ways.
- Trial name
- NCT07799623
- Testing
- Ciprofol, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Multiple Myeloma
Melphalan+Prednisolon With or Without Thalidomide in Previously Untreated Elderly Patients With Multiple Myeloma
This is a multi-centre Phase III randomized controlled study of patients with multiple myeloma (MM). Eligible patients who are not candidates for transplantation will be randomized to receive eight courses of…
- Trial name
- NCT00934154
- Testing
- Thalidomide, Melphalan+Prednisolone
- Where
- 9 sites in Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Cigdem Sahinbas YILMAZ
Elderly Patient, Cancer
the Impact of Occupational Therapy : a Multicenter Randomized Controlled Trial
The purpose of this randomized controlled superiority trial is to evaluate the impact of occupational therapy assessment and intervention on the quality of life of elderly cancer patients.
- Conditions
- Elderly Patient, Cancer, Quality of Life
- Trial name
- OCEAN-OT (NCT05878782)
- Testing
- MCRO+Occupational therapy, MCRO without intervention
- Volunteers
- 232 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancer, Machine Learning
Predict 5-Year Survival in Elderly Gastric Cancer
In this study, elderly patients with gastric cancer who underwent radical gastrectomy in Union Hospital Affiliated to Fujian Medical University from 2012 to 2018 were included as a derived cohort, and the training set and…
- Trial name
- NCT06208046
- Where
- China
- Volunteers
- 2,187 people
- Sponsor
- Fujian Medical University
Cancer (Solid Tumors), Geriatric Oncology
TRTRM (ACTTOP) -Guided Dosing Strategy in Older Patients With Cancer
Older adults receiving systemic cancer treatments are at increased risk of developing severe treatment-related toxicities (TRT).
- Trial name
- NCT07484932
- Testing
- TRTRM-guided risk-stratified treatment strategy
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Breast Neoplasms, Neoplasm Metastasis
Study in Letrozole Combined With Metronomic Oral Cyclophosphamide in Elderly Metastasis Breast Cancer Patients
This is a randomized clinical trial to investigate the efficacy of letrozole combined with metronomic oral cyclophosphamide in elderly metastasis breast cancer patients.
- Trial name
- NCT02583828
- Testing
- Cyclophosphamide 50mg, Letrozole 2.5 mg
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Lymphoma
Rituximab and Combination Chemotherapy in Treating Older Patients With Previously Untreated B-Cell Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them.
- Trial name
- NCT00290667
- Testing
- pegfilgrastim, rituximab, cyclophosphamide
- Where
- 338 sites in Czechia, France and 7 more
- Volunteers
- 586 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Solid Cancer, Lymphopenia
PRaG-1 Plus PRaG Therapy in in Elderly Patients With Advanced Solid Tumors: A Prospective Clinical Trial (PRaG 10.0)
The goal of this clinical trial is to learn if a combination treatment using PRaG-1 Cordycepin Tablets with radiation therapy, immune-boosting injections, and immunotherapy drugs can help patients with advanced solid tumors.
- Conditions
- Solid Cancer, Lymphopenia, Radiotherapy, Immune Checkpoint Inhibitor
- Trial name
- NCT07267234
- Testing
- PD -1/PD-L1 monoclonal antibody
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Undernutrition, Cancer
Management of Malnutrition in Oncogeriatrics
In France, undernutrition affects almost three million people, a third of whom are over 70 (Diagnosing undernutrition earlier in the elderly aged 70 and over, n.d.).
- Trial name
- NCT06425315
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Postoperative Delirium (POD), Gynecologic Cancers
Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology
Early postoperative delirium (POD) is a common and distressing neuropsychiatric complication frequently observed in elderly patients undergoing major surgical interventions, including radical and cytoreductive gynecologic…
- Conditions
- Postoperative Delirium (POD), Gynecologic Cancers, Malnutitrion
- Trial name
- NCT07877285
- Testing
- Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Hodgkin Lymphoma, Coexisting Medical Conditions
Study Of Nivolumab Alone, Or In Combination With Vinblastin In Patients With Classical Hodgkin Lymphoma
This study is a multicentric phase II open-label trial consisting of 6 cycles Nivolumab (2 weeks interval) followed by a PET-CT scan. The treatment will be allocated according to PET and CT scan responses.
- Trial name
- NCT03580408
- Testing
- Nivolumab, Vinblastin
- Where
- 51 sites in Belgium, France
- Volunteers
- 64 people
- Sponsor
- The Lymphoma Academic Research Organisation
Sarcopenia, Lung Cancer
Lung Cancer Surgery in Sarcopenia Patients With Old Age
The presence of sarcopenia before lung resection surgery might be an important factor of short-term and long-term prognosis in lung cancer patients.
- Trial name
- LUCAS-PEN (NCT05346185)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Coronary; Ischemic, Arrhythmias, Cardiac
Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality
With the increasing aging population demographics and life expectancies, the number of very elderly patients undergoing surgery is rising.
- Conditions
- Coronary; Ischemic, Arrhythmias, Cardiac, Heart Failure, Peripheral Vascular Diseases
- Trial name
- OPTI-AGED (NCT02668250)
- Testing
- OPTI-AGED, Usual Care
- Where
- 29 sites in France
- Volunteers
- 2,495 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Metastatic Breast Cancer, 70 Years Old Patients and Over
Evaluating Lapatinib + Capecitabine in Patients Aged 70 and Over With HER2 Metastatic Breast Cancer.
GERICO 09/0907 is a Phase II multicentric trial evaluating the toxicity and activity of the combination of lapatinib and capecitabine in locally advanced or metastatic breast cancer over expressing HER2 for patients aged ≥ 70 who…
- Conditions
- Metastatic Breast Cancer, 70 Years Old Patients and Over, After One Line of Chemotherapy With Trastuzumab
- Trial name
- GERICO09 (NCT01262469)
- Testing
- lapatinib + capecitabine
- Where
- 20 sites in France
- Volunteers
- 4 people
- Sponsor
- UNICANCER
Multiple Myeloma, Frailty
Individualized Dynamic Frailty-tailored Therapy (DynaFiT) in Elderly Patients With NDMM
Frailty is dynamic and confers poor outcomes in elderly patients with newly diagnosed multiple myeloma (NDMM), mainly because of the high prevalence of treatment discontinuation due to intolerability.
- Trial name
- DynaFiT (NCT06099912)
- Where
- China
- Volunteers
- 131 people
- Sponsor
- FengYan Jin
Acute Myeloid Leukemia
GOELAMS SA4 Study: the Role of Fludarabine in the Treatment of Acute Myeloid Leukemia in the Elderly
In this study, patients were randomly assigned to either receive fludarabine or not (20 mg/m2/d) in addition to induction chemotherapy, consolidation chemotherapy and the 3 subsequent re-induction courses during maintenance.
- Trial name
- NCT00925873
- Testing
- Active comparator (no fludarabine), Experimental (fludarabine)
- Where
- France
- Volunteers
- 303 people
- Sponsor
- French Innovative Leukemia Organisation
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