Clinical trials: Elderly Cancer Patients
Breast Cancer, Cognitive/Functional Effects
Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly Diagnosed Breast Cancer or Colon Cancer
RATIONALE: Gathering health information from older patients undergoing chemotherapy may help doctors plan better treatment and improve the quality of life for these patients.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Colorectal Cancer, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00873600
- Testing
- chemotherapy, medical chart review, questionnaire administration
- Sponsor
- Case Comprehensive Cancer Center
Non-small Cell Lung Cancer
Pemetrexed With or Without Carboplatin for Elderly Non-squamous Non-small Cell Lung Cancer
The number of NSCLC patients above 70 years of age who are non-squamous histology is increasing around the world. Although previous guidelines often recommend single agent therapy for NSCLC, recent studies suggest that platinum…
- Trial name
- ACE (NCT01593293)
- Testing
- PemCarbo, Pem only
- Where
- South Korea
- Volunteers
- 266 people
- Sponsor
- Asan Medical Center
Lymphoma, Mantle-Cell
Induction Chemotherapy (R-CHOP Vs. R-FC) Followed by Interferon Maintenance Versus Rituximab Maintenance in MCL
The aim of this study is to answer the following independent questions in the treatment of mantle cell lymphomas: Can rituximab-fludarabine, cyclophosphamide (R-FC) improve the reduction of lymphoma mass compared to…
- Trial name
- MCLelderly (NCT00209209)
- Testing
- Rituximab, Cyclophosphamide, Doxorubicin
- Where
- 7 sites in Czechia, Denmark and 5 more
- Volunteers
- 570 people
- Sponsor
- European Mantle Cell Lymphoma Network
Pancreatic Cancer
Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma
NutriCa65-PDAC is a clinical study for patients aged 65 years or older with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
- Trial name
- NutriCa65-PDAC (NCT07821554)
- Testing
- Experimental: Personalised nutritional care delivered by a trained dietitian
- Where
- 5 sites in Denmark, Italy and 3 more
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
Gastric Cancer
The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer
The purpose of this study is to find out the effect of Dexmedetomidine for treatment of sleep deprivation, pain relief and postoperative recovery on middle-aged and elderly Patients with Gastric Cancer.
- Trial name
- NCT03117023
- Testing
- dexmedetomidine
- Volunteers
- 50 people
- Sponsor
- Nanjing PLA General Hospital
Lung Cancer
Pemetrexed, Carboplatin, and Bevacizumab as First-Line Therapy in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00798603
- Testing
- bevacizumab, carboplatin, pemetrexed disodium
- Where
- 217 sites in United States
- Volunteers
- 65 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
A Novel Approach Utilizing Organ Specific Age Proteomics
This study compares changes in P16INK4A expression and plasma proteomic signatures of specific organ age pre- and post-chemotherapy in women treated with adjuvant chemotherapy for early-stage breast cancer.
- Trial name
- NCT06789653
- Testing
- p16INK4a mRNA level assessment, organ-specific protein signatures assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Glioblastoma, Malignant Glioma
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy
This phase II trial studies how well fluorodopa F 18-positron emission tomography/magnetic resonance imaging scan (18F-DOPA-PET/MRI) works in imaging elderly patients with newly diagnosed grade IV malignant glioma or glioblastoma…
- Trial name
- NCT03778294
- Testing
- Computed Tomography, Fluorodopa F 18, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Frailty, Cancer
Predictive Value of Geriatric Oncology Screening and Geriatric Assessment in Older Patients With Solid Cancers
A Randomized Clinical Trial examining the effects of Comprehensive Geriatric Assessment as an add on to oncologic treatment. Participants included are cancer patients found eligible for oncologic treatment, age 70 or more, and…
- Conditions
- Frailty, Cancer, Age
- Trial name
- PROGNOSIS-RCT (NCT04686851)
- Testing
- Comprehensive Geriatric Assessment and follow-up
- Where
- Denmark
- Volunteers
- 322 people
- Sponsor
- Odense University Hospital
Cancer, Radiotherapy
Improved Function and Quality of Life for Older Patients Receiving Radiotherapy, Part II
This cluster randomized controlled pilot study is designed to test the feasibility, and potential effect of a multicomponent, community-based intervention aiming to improve quality of life (QoL) and function for older patients…
- Conditions
- Cancer, Radiotherapy, Older Patients
- Trial name
- NCT03881137
- Testing
- Geriatric assessment with management
- Where
- 2 sites in Norway
- Volunteers
- 178 people
- Sponsor
- Sykehuset Innlandet HF
Surgery, 75 Years Old and More
Place of Comprehensive Geriatric Assessment in Patients ≥ 75 Years Care, With Breast Cancer, After Screening With FOG (Oncology Geriatric Filter)
The risk of diagnosis of cancer increases with age, especially breast cancer in elderly women. Elderly population is heterogeneous, regarding physiological reserves, comorbidities, disability and geriatric conditions.
- Conditions
- Surgery, 75 Years Old and More, Female Breast Cancer
- Trial name
- NCT03059875
- Testing
- Medical consultation for a Standardized Geriatric Evaluation
- Where
- 6 sites in France
- Volunteers
- 79 people
- Sponsor
- Poitiers University Hospital
Colorectal Cancer
Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00303771
- Testing
- fluorouracil, irinotecan hydrochloride, leucovorin calcium
- Where
- 77 sites in France
- Volunteers
- 282 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Frailty, Postoperative Complications
Mortality Predictors in Patients 80+ After Major Abdominal Surgery: Role of Frailty and Physiological Reserve
The aim of this study is to identify independent risk factors for 30-day mortality in patients aged 80 and over who have undergone major abdominal surgery.
- Conditions
- Frailty, Postoperative Complications, Aged, 80 and Over, Abdomen Cancer
- Trial name
- NCT07440095
- Testing
- Major Abdominal Surgery and Frailty Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Colorectal Cancer
Predictors of One-Year Mortality After Curative Surgery in Patients Aged 80 Years or Older With Non-Metastatic Colorectal Cancer
The aim of this study is to determine which preoperative factors are associated with one-year postoperative mortality in patients aged ≥80 years undergoing curative surgery and compare outcomes between patients with or without…
- Trial name
- NCT06704646
- Testing
- Curative intent surgery
- Volunteers
- 310 people
- Sponsor
- National Taiwan University Hospital
Acute Myeloid Leukemia (AML)
Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation
This is a randomized, Phase-III, two-arm, open-label, multi-center study in adult patients with AML and NPM1 mutation ineligible for intensive chemotherapy.
- Trial name
- NCT01237808
- Testing
- Cytarabine, Etoposide, All-trans retinoic acid (ATRA)
- Where
- 33 sites in Germany
- Volunteers
- 144 people
- Sponsor
- University of Ulm
Ovarian Cancer
MITO-5: Weekly Carboplatin and Paclitaxel as First Line Chemotherapy for Elderly Patients With Ovarian Cancer
The purpose of this study is to evaluate the toxicity and activity of weekly administration of carboplatin and paclitaxel as first-line chemotherapy for elderly patients with ovarian cancer stage IC-IV.
- Trial name
- MITO-5 (NCT00401674)
- Testing
- carboplatin, paclitaxel
- Where
- 10 sites in Italy
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute, Naples
Acute Myeloid Leukemia
Elderly Patients With Acute Myeloid Leukemia (AML), Maintenance Phase After Complete Remission (CR)
Phase II Multicentric Trial Open Label, Multicenter, randomized to evaluate the efficacy of a Maintenance Therapy in First Complete Remission After Induction for Elderly (≥ 60) Fit Patients With Poor Prognosis Acute Myeloid…
- Trial name
- NCT01301820
- Testing
- azacitidine, Lenalidomide
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Innovative Leukemia Organisation
Non-small Cell Lung Cancer (NSCLC) Stage IV, Locally Advanced Non-Small Cell Lung Cancer
An Exploratory Clinical Study Of Bempemab Combined With Anlotinib As First-Line Treatment For Elderly Patients With Locally Advanced Or Metastatic Non-Small-Cell Lung Cancer
This exploratory clinical study evaluates the efficacy and safety of combining benmelstobart (a PD-L1 inhibitor) with anlotinib (a multi-target anti-angiogenic TKI) as a first-line, chemotherapy-free treatment for elderly…
- Conditions
- Non-small Cell Lung Cancer (NSCLC) Stage IV, Locally Advanced Non-Small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer
- Trial name
- BEACON-OLD (NCT07849712)
- Testing
- Benmelstobart Combined With Anlotinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang Cancer Hospital
Multiple Myeloma
Patient and Care Partner Experiences Living With Multiple Myeloma (PaCE-MM)
This research study is explore the impact over time of multiple myeloma and its associated treatments on the physical and cognitive function and quality of life of patients and their care partners and how these impacts affect the…
- Trial name
- PaCE-MM (NCT05276622)
- Testing
- Comprehensive Geriatric Assessment, Qualitative patient-care partner interviews, Surveys on well-being and function
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Leukemia
Paclitaxel in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I/II trial to study the effectiveness of paclitaxel in treating patients with refractory or…
- Trial name
- NCT00003230
- Testing
- paclitaxel
- Where
- 9 sites in Switzerland
- Volunteers
- 33 people
- Sponsor
- Swiss Cancer Institute
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