Clinical trials: Elderly Cancer Patients
Acute Myeloid Leukemia
Efficacy Study of Anti-KIR Monoclonal Antibody as Maintenance Treatment in Acute Myeloid Leukemia (EFFIKIR)
Double-Blind Placebo-Controlled Randomized Phase 2 Study evaluating the efficacy of lirilumab (IPH2102/BMS-986015) as Maintenance Treatment administered in elderly patients with Acute Myeloid Leukemia (AML) in first complete…
- Trial name
- EFFIKIR (NCT01687387)
- Testing
- IPH2102 at 0.1 mg/kg, IPH2102 at 1 mg/kg
- Where
- 43 sites in France
- Volunteers
- 152 people
- Sponsor
- Innate Pharma
Breast Cancer Female
Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients
The elderly patients over 65 years old with breast cancer have concomitant diseases, poor tolerance to conventional treatment, and the specific prognosis of breast cancer is relatively good.
- Trial name
- EEBC (NCT05680194)
- Testing
- operation, Bisphosphonate
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
AML, Adult
Epidemiological Study of a Prospective Cohort of Patients Aged 60 and Over Managed for Acute Myeloid Leukemia (AML) and Receiving Intensive Induction Therapy
This observational epidemiological study targets patients aged 60 and over with de novo or secondary acute myeloblastic leukemia suitable for intensive receive intensive induction therapy as defined by the group.
- Trial name
- NCT06891144
- Where
- 27 sites in France
- Volunteers
- 1,000 people
- Sponsor
- French Innovative Leukemia Organisation
Grief
A Finding Balance Writing Intervention for Older Bereaved Caregivers
The overall purpose of this study is to develop and pilot-test a theory-based psychosocial supportive "finding balance" intervention for older, bereaved spousal caregivers of a palliative cancer patient.
- Trial name
- NCT01416779
- Testing
- Writing Intervention
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Non-small Cell Lung Cancer
Surgical Treatment of Elderly Patients With cT1N0M0 Non-small Cell Lung Cancer Comparison Between Sublobar Resection and Lobectomy
The role of sublobar resection(Wedge resection or anatomic segmentectomy) for small(≤ 2cm) early stage non-small cell lung cancer has been studied by Lung Cancer Study Group and is being studied by several ongoing trials.
- Trial name
- STEPS (NCT02360761)
- Testing
- VATS, Thoracotomy
- Where
- 6 sites in China
- Volunteers
- 339 people
- Sponsor
- Peking University People's Hospital
Acute Myeloid Leukemia
Everolimus (RAD001) in Elderly Patients With Acute Myeloid Leukemia
The main goal of this study is to assess the safety and tolerability of RAD001 in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy.
- Trial name
- NCT00636922
- Testing
- RAD001(Everolimus)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Bayside Health
Acute Myeloid Leukemia, Adult
Decitabine in Combination With Low-dose Cytarabine in Elderly Patients With Acute Myeloid Leukemia
This prospective multicenter clinical study was designed to assess the efficacy and safety of decitabine in combination with low-dose cytarabine induction treatment for elderly patients with newly diagnosed acute myeloid leukemia…
- Trial name
- NCT02985372
- Testing
- Decitabine, Cytarabine
- Volunteers
- 30 people
- Sponsor
- Chunyan Ji
Glioblastoma Multiforme
Radiosurgery for Glioblastoma Multiforme
Conventional radiation for 6 weeks is not well tolerated by the elderly. Shorter courses (over 3-5 weeks) of radiation have been shown to be equivalent in outcome the elderly- particularly in patients who are generally in poor…
- Trial name
- NCT00456612
- Testing
- CyberKnife
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beth Israel Deaconess Medical Center
Colon Cancer, Frailty
The "SPARCOL" Study
Mortality following elective colorectal cancer surgery range between 2.5-6% and increase for the elderly and frail patient regardless of T-stage.
- Trial name
- NCT05734300
- Testing
- Combined Endoscopic Laparoscopic Surgery (CELS), Standard resection
- Where
- 3 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Zealand University Hospital
Colorectal Neoplasms
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the…
- Trial name
- NCT00236249
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Incidence of Postoperative Delirium
Delirium is a frequently occurred cerebral complication in elderly patients after surgery, and its occurrence is associated with worse outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012984
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Leukemia
Physical Activity in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy
RATIONALE: Physical activity sessions may help improve physical function, quality of life, and symptoms caused by chemotherapy in older patients with acute myelogenous leukemia.
- Trial name
- NCT00554489
- Testing
- exercise intervention
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Wake Forest University Health Sciences
Locally Advanced Esophageal Squamous Cell Carcinoma
Consolidation of Toripalimab After Chemoradiotherapy in Elderly Esophageal Cancer (EC-CRT-007)
Although definitive chemoradiotherapy (CRT) is the standard treatment option for unresectable locally advanced esophageal cancer, elderly patients tolerate intravenous concurrent CRT less well with age and comorbidities.
- Trial name
- EC-CRT-007 (NCT06187597)
- Testing
- S-1, Toripalimab, Intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sun Yat-sen University
Hepatic Malignancies, Comprehensive Geriatric Assessment
Preoperative Oncogeriatric Assessment in Patients Undergoing Hepatectomy
This study aims to bridge the gap between geriatric medicine and surgical oncology. The findings will provide valuable insights into optimizing perioperative care for older adults, enhancing surgical safety, and improving…
- Conditions
- Hepatic Malignancies, Comprehensive Geriatric Assessment, Hepatectomy
- Trial name
- NCT07537569
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gastric Cancer, Adenocarcinoma of the Esophagogastric Junction
Oxaliplatin and 5-Fluorouracil With or Without Docetaxel in Elderly Patients (>65 y) With Stomach and Esophagus Cancer
In this trial, FLOT will be evaluated as therapy option for elderly patients (>65 years) with advanced gastric cancer in comparison to the well established FLO scheme.
- Trial name
- NCT00737373
- Testing
- Docetaxel, 5-Fluorouracil, Oxaliplatin
- Where
- Germany
- Volunteers
- 143 people
- Sponsor
- Krankenhaus Nordwest
Colorectal Cancer
The Effect of IoC on Analgesia for Elderly Patients With Postoperative Effectiveness
The morbidity of colorectal cancer and the surgery number among elderly is growing. The investigators need to provide more advanced and specific monitoring technology for these patients.
- Trial name
- NCT02827682
- Testing
- Angel-6000D Multiparameter Anesthesia Monitor (IoC), BIS VISTA Monitor (BIS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Lung Cancer, Non-small Cell Lung Cancer
Comprehensive Geriatric Assessment in Elderly Non-Small Cell Lung Cancer Patients
Lung cancer is responsible for one of the highest incidences of cancer-related mortality globally, and non-small cell lung cancer (NSCLC) accounts for the biggest subtype of lung cancer.
- Trial name
- NCT05230888
- Testing
- Questionnaires about symptoms
- Where
- United Kingdom
- Sponsor
- University of Hull
Neoplasm, Plasma Cell, Lymphoma
Impact of Chemotherapeutic Treatments in Patients Aged 75 Years and Over Treated for Lymphoid Hematological Malignancy
The aim of the study is to assess the prevalence of functional decline in elderly patients treated with chemotherapy or immunochemotherapy for lymphoid hematologic malignancies.
- Trial name
- LYMPHOLD (NCT05101759)
- Testing
- Comprehensive Geriatric Assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Delirium, Aged
Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients
The primary aim of this interventional study is to investigate the impact of perioperative administration of Maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly…
- Conditions
- Delirium, Aged, Lung Neoplasms, Robotic Surgical Procedures
- Trial name
- NCT05834569
- Testing
- Acetaminophen and Ibuprofen, Normal saline
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Korea University Guro Hospital
Lymphoblastic Leukemia, Acute
Tyrosine Kinase Inhibitors and Low Intensity Chemotherapy in Ph+ ALL
The use of imatinib in combination with chemotherapy is now considered as the gold standard for the treatment of Ph+ ALL. The complete remission (CR) rate is 90% versus 20% to 40% with chemotherapy alone.
- Trial name
- EWALL_OBS (NCT02888977)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Versailles Hospital
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