Clinical trials: Elderly Cancer Patients
Elderly, Breast Cancer
Innovative and Cooperative Pathway Integrating Oncogeriatric, Pharmaceutical and Pharmacological Follow-up in Elderly Patients.
The incidence of cancer among older adults is increasing as a result of longer life expectancy. Therapeutic advances have led oncologists to propose new available treatments for these patients, particularly oral therapies…
- Conditions
- Elderly, Breast Cancer, Lung Cancer, Prostate Cancer
- Trial name
- POG (NCT07802847)
- Testing
- Experimental
- Where
- France
- Volunteers
- 794 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Acute Myeloblastic Leukemia
Study With Temsirolimus Added to Standard Chemotherapy for Patients Over 60 Years With Acute Myeloblastic Leukemia
Standard chemotherapy is capable of eliminating most leukemic blasts in acute myeloblastic leukemia (AML), while leukemia-initiating cells are not sufficiently eradicated.
- Trial name
- TOR-AML (NCT01611116)
- Testing
- sodium chloride solution 0.9%, temsirolimus
- Where
- 5 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Goethe University
Lymphoma, Digestive System Diseases
Development of an Evaluation Method of Elderly Condition in Patient Receiving Chemotherapy Treatment
Incidence of cancer in 75+ years old is 16,500 new cases per year, more than fifty percent of people with cancerThey are very few therapeutic trials dedicated.
- Conditions
- Lymphoma, Digestive System Diseases, Ovarian Diseases, Pulmonary Disease
- Trial name
- PHRC2003 (NCT00210249)
- Where
- 18 sites in France
- Volunteers
- 364 people
- Sponsor
- Institut Bergonié
Acute Myeloid Leukemia
Trial of CPX-351 in Newly Diagnosed Elderly AML Patients
The study investigates if CPX-351 will be a) more effective than the standard AML treatment and b) more tolerable than the standard AML treatment regimens.
- Trial name
- NCT00788892
- Testing
- CPX-351, Cytarabine, Daunorubicin
- Where
- 28 sites in United States, Canada
- Volunteers
- 126 people
- Sponsor
- Jazz Pharmaceuticals
Hodgkin's Disease
Study of Prednisone, Vinblastine, Doxorubicin, and Gemcitabine in Elderly Patients With Advanced Stages Hodgkin's Lymphoma
The objectives of this study are to assess the feasibility and efficacy of a combination chemotherapy (PVAG) in elderly patients with advanced stages Hodgkin's lymphoma.
- Trial name
- NCT00147875
- Testing
- Prednisone, Vinblastine, Doxorubicin (Adriamycin)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Gynecologic Cancer, Frailty
Cognitive and Physical Frailty as Predictors of Decision Satisfaction in Geriatric Gynecologic Oncology
This prospective observational study aims to evaluate the association between preoperative cognitive function, measured by the Montreal Cognitive Assessment (MoCA), and physical frailty, assessed using the Clinical Frailty Scale…
- Conditions
- Gynecologic Cancer, Frailty, Cognitive Impairment, Geriatric Oncology
- Trial name
- GYNCOGFRAIL (NCT07085000)
- Testing
- No Intervention - Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir City Hospital
Dental Caries, Cervical Caries
Clinical Performance of High Viscous Glass Ionomer Cervical Restorations With Silver-Modified Atraumatic Restorative Technique (SMART) Versus Conventional Treatment in Elderly Cancer Patients. (A 12-month Randomized Clinical Trial)
This study will evaluate the clinical performance of glass ionomer cervical restorations placed using the Silver-Modified Atraumatic Restorative Technique (SMART) compared with conventional restorative treatment in elderly cancer…
- Trial name
- NCT07803757
- Testing
- Silver Diamine Fluoride (SDF, 38%), Conventional Tooth Preparation, High-Viscosity Glass Ionomer Cement
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cervical Cancers
Effect of Nurse Navigation Program on Cervical Cancer Screening Behaviour of the Women Aged 30-65
This study was designed as a randomized controlled experimental study to examine the effect of the 'Nurse Navigation Program' on cervical cancer screening behaviors (Human Papilloma Virus (HPV) DNA screening test and/or pap smear…
- Trial name
- NCT06647992
- Testing
- Nurse Navigation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TURKAN OZDAS
Astrocytoma, Grade III, Glioblastoma
Multi-kinase Inhibitor TG02 (TG02) in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma.
This is a three parallel cohort, open-labeled, non-randomized, multicenter study. All three cohorts will enroll independently.
- Trial name
- STEAM (NCT03224104)
- Testing
- TG02, Radiation Therapy, Temozolomide
- Where
- 10 sites in Austria, France and 3 more
- Volunteers
- 71 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Multiple Myeloma
Treatment of Newly Diagnosed Elderly Patients With Multiple Myeloma
In multiple myeloma, combination chemotherapy with melphalan plus prednisone has been used since the 1960s and is regarded as the standard of care in elderly patients.
- Trial name
- NCT00367185
- Testing
- Thalidomide
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Lille
Elderly Patients, Solid Organ Cancer
Epidural Anesthesia and Long-term Outcomes in Elderly Patients After Surgery
Surgical resection is one of the most important treatments for solid organ cancer. Whereas cancer recurrence and/or metastasis are the major reasons of treatment failure.
- Conditions
- Elderly Patients, Solid Organ Cancer, Surgical Resection, Epidural Anesthesia
- Trial name
- NCT03335826
- Testing
- Combined epidural-general anesthesia, General anesthesia
- Where
- 5 sites in China
- Volunteers
- 1,802 people
- Sponsor
- Peking University First Hospital
Breast Cancer, Elderly
Gene Polymorphisms and Gene Products as Biological Markers of Aging and Correlation With Clinical Geriatric Assessment, Tolerance of Chemotherapy and Outcome in Elderly Breast Cancer Patients
The goal is to study the biology of aging in breast cancer patients, and to study the impact of chemotherapy on aging related blood biomarkers.
- Trial name
- EBS (NCT00849758)
- Where
- 2 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Small Cell Lung Cancer ( SCLC )
A Single-arm, Exploratory Clinical Study Evaluating the Efficacy and Safety of Bevacizumab in Combination With Anlotinib and Etoposide as First-line Therapy for Elderly Patients With Small-cell Lung Cancer or Those Who Are Intolerant to Intensive Chemotherapy
A single-arm exploratory clinical study to observe and evaluate the first-line treatment of elderly and treatment-intolerant patients with small cell lung cancer using benmelstobart in combination with anlotinib and etoposide.
- Trial name
- SCLC (NCT07728955)
- Testing
- benmelstobart in combination with anlotinib and etoposide
- Volunteers
- 64 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Colorectal Neoplasms
Yield and Safety of Colonoscopy in Patients Older Than 80 Years
The aim of the study is to study the risk of colorectal cancer and polyps in people older than 80 years compared to the younger age group.
- Trial name
- NCT00590434
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Midwest Biomedical Research
Gastric Cancer
Evaluation of Efficacy and Safety of FOLFIRI Association Treatment in Patients 70 Years of Age and Older With Gastric Cancer
The number of patients over 70 years old with cancer is increasing in France. This population is heterogenous: physiological functions, presence of co-morbidities, and autonomy can vary a lot between subjects of the same age.
- Trial name
- CEPAFIRI (NCT00210184)
- Testing
- Irinotecan associated to fluorouracil and leucovorin
- Where
- 6 sites in France
- Volunteers
- 42 people
- Sponsor
- Institut Bergonié
Leukemia, Myeloid, Acute, Hematologic Neoplasms
Trial of Pimasertib in Hematological Malignancies
This is an open-label, multi-center, dose-escalation trial of pimasertib (MSC1936369B) in blood and bone marrow cancers. The trial will be conducted in two parts: Part 1 (safety run-in period): Will determine the maximum…
- Trial name
- NCT00957580
- Testing
- Pimasertib
- Where
- 9 sites in United States, France
- Volunteers
- 81 people
- Sponsor
- EMD Serono
Postoperative Delirium, Postoperative Neurocognitive Disorder
Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms
This is a prospective cohort study to explore the differences of serum indicators between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative…
- Conditions
- Postoperative Delirium, Postoperative Neurocognitive Disorder, Gastrointestinal Surgery
- Trial name
- NCT06466096
- Testing
- no intervention
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Non-Small Cell Lung Cancer
Cancer of the Lung And SeneScencE - Prospective Cohort 1
The main objective is to identify and assess the predictive value of ageing and senescence biomarkers (methylome, telomeres, inflammageing) and senescent cells in tissues to improve prognosis assessment older patients with…
- Trial name
- CLASSE-P1 (NCT06923618)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 385 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aged, Neoplasms
Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery
Surgery is one of the major treatment methods for patients with solid organ cancer. And, alone with the ageing process, more and more elderly patients undergo surgery for cancer.
- Conditions
- Aged, Neoplasms, Surgical Procedure, Operative, Anesthesia, Inhalation
- Trial name
- NCT05343260
- Testing
- Sevoflurane, Propofol
- Where
- 15 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
Other Cancer
Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly
In this research study, the investigators are working to help oncologists better serve patients by delivering more patient-centered, goal-concordant care that may improve health care delivery.
- Trial name
- ACP-PEACE (NCT03609177)
- Testing
- Clinician Communication Skills Training, Advance Care Planning (ACP) Decisions Videos Decisions Aids, Video Declarations (ViDec)
- Where
- 4 sites in United States
- Volunteers
- 13,800 people
- Sponsor
- Dana-Farber Cancer Institute
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