Clinical trials: Elderly Cancer Patients
Lymphoma, Large-Cell, Diffuse
R-ICE Versus R-DHAP in Patients Aged 18-65 With Relapse Diffuse Large B-cell Lymphoma
The primary objective of this study is to evaluate the efficacy and safety of induction therapy R-ICE in comparison to R-DHAP after 3 cycles adjusted to successful mobilization of stem cells in patients with previously treated…
- Trial name
- NCT00137995
- Testing
- Rituximab, Etoposide, Carboplatine
- Where
- 10 sites in United States, Australia and 8 more
- Volunteers
- 481 people
- Sponsor
- Lymphoma Study Association
Colorectal Cancer
Dyadic Intervention for Psychological Distress of Patients With Colorectal Cancer and Their Spouses
The overall aim of the study is to evaluate the effects of a dyadic intervention on mutuality, psychological strengths (i.e., illness cognition and dyadic coping), illness-related communication, psychological distress, and QoL…
- Trial name
- NCT06326437
- Testing
- 6-week dyadic intervention
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer
Neoadjuvant PD-1 Blockade for Elderly Esophageal Squamous Cell Carcinoma (BLESS)
The investigators will conduct a prospective phase 2 study to evaluate the efficacy and safety of neoadjuvant PD-1 blockade monotherapy with toripalimab in elderly patients with locally advanced resectable esophageal squamous…
- Trial name
- BLESS (NCT06385730)
- Testing
- neoadjuvant anti-PD-1, neoadjuvant anti-PD-1 with LDRT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Chest Hospital
Polycystic Ovary Syndrome
Plasma Levels of GDF-9 and GDF-15 in Patients With Polycystic Ovary Syndrome.
The purpose of this study is to determine the plasma levels of GDF-9 and GDF-15, and their association with bone and cardiovascular parameters in patients with Polycystic Ovary Syndrome.
- Trial name
- NCT01644305
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Ankara Education and Research Hospital
Metastatic Colorectal Cancer
Efficacy/Safety Study of Bevacizumab,Capecitabine,Oxaliplatin to Metastatic Colorectal Adenocarcinoma Elderly Patients.
The purpose of this study is to determine whether bevacizumab, capecitabine and oxaliplatin are an effective and safe first line of treatment for elderly patients with metastatic colorectal adenocarcinoma.
- Trial name
- BECOX (NCT01067053)
- Testing
- bevacizumab, capecitabine, oxaliplatin
- Where
- 15 sites in Spain
- Volunteers
- 69 people
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Acute Myeloid Leukemia
Efficacy of Sorafenib Added to Standard Primary Therapy in Elderly Patients With Newly Diagnosed AML
The primary purpose of the study is to determine, whether the addition of Sorafenib to standard chemotherapy in elderly patients with newly diagnosed AML improves treatment results (event free survival).
- Trial name
- NCT00373373
- Testing
- Sorafenib
- Where
- 18 sites in Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Muenster
Non-small Cell Lung Cancer
Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer
The purpose of this study is it to determine how well patients with non-small cell lung cancer respond to cetuximab plus vinorelbine.
- Trial name
- NCT00165334
- Testing
- Cetuximab, Vinorelbine (Navelbine)
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Dana-Farber Cancer Institute
Multiple Myeloma, Hematologic Diseases
Comparison of Geriatric Screening Methods in Newly Diagnosed Multiple Myeloma Patients
The purpose of this study is to compare clinical judgment and comprehensive geriatric assessment as screening tools for optimization of treatment for newly diagnosed elderly multiple myeloma patients.
- Trial name
- COMPASS (NCT02918695)
- Where
- 20 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oesophagus Cancer, Elderly Patients
Chemoradiotherapy in Elderly Patients With Oesophagus Cancer
Management of elderly patient with cancer is a therapeutic challenge and a public health problem. The mean age of esophageal cancer is 64.5 years and 72.1 years in men and women respectively.
- Trial name
- OSAGE (NCT02735057)
- Testing
- Carboplatin
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
AML, Adult
Epidemiological Study of a Prospective Cohort of Patients Aged 60 and Over Managed for Acute Myeloid Leukemia (AML) and Receiving Intensive Induction Therapy
This observational epidemiological study targets patients aged 60 and over with de novo or secondary acute myeloblastic leukemia suitable for intensive receive intensive induction therapy as defined by the group.
- Trial name
- NCT06891144
- Where
- 27 sites in France
- Volunteers
- 1,000 people
- Sponsor
- French Innovative Leukemia Organisation
Acute Myeloid Leukemia, Adult
Up-front Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Patients Aged 65-75
Patients with acute myeloid leukemia aged 65-75 have a very poor prognosis, irrespective of the treatment strategy, including demethylating agents or conventional chemotherapy.
- Trial name
- NCT03902665
- Testing
- Up-front allogeneic hematopoietic stem cell transplantation (HSCT)
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Comprehensive Nutritional Geriatric Assessments in Identifying Malnutrition in Older Cancer Participants
This trial studies how well comprehensive nutritional geriatric assessments work in identifying malnutrition in older cancer participants.
- Trial name
- NCT03035604
- Testing
- Comprehensive Geriatric Assessment
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Sarcoma
Clinical Study of Metronomic Oral Cyclophosphamide in Patients With Advanced Sarcomas
This is a single arm phase II clinical study to evaluate the efficacy and safety of metronomic oral cyclophosphamide in elderly and/or pre-treated patients with advanced sarcomas.
- Trial name
- NCT01716689
- Testing
- oral cyclophosphamide
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National Cancer Centre, Singapore
Giant Cell Glioblastoma, Glioblastoma
Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma
- Trial name
- NCT01149850
- Testing
- bevacizumab, temozolomide, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Acute Myelogenous Leukemia, Myelodysplastic Syndromes
Clofarabine and Ara-C for the Treatment of Relapsed AML and Untreated MDS
The purpose of this trial is to to determine the safety and effectiveness of therapeutic combination - Clofarabine and Cytarabine for the treatment of AML and MDS.
- Conditions
- Acute Myelogenous Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia
- Trial name
- NCT00334074
- Testing
- Clofarabine and Cytarabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Non Hodgkin's Lymphoma
Adjuvant Low Dose Total Body Irradiation in Elderly Patients With Diffuse Large B-Cell Lymphoma
The purpose of this study is to determine whether the application of low dose total body irradiation following chemo-immuntherapy in elderly patients with aggressive with non-Hodgkin's lymphoma would be safe and potentially…
- Trial name
- NCT00834951
- Testing
- Low dose total body irradiation
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Colorectal Cancer, Neoplasm Metastasis
Study of Oxaliplatin, Capecitabine, and Bevacizumab to Treat Older Patients With Colorectal Cancer
Currently there is no one standard of care for older patients with metastatic colorectal cancer. The study will examine the tumor response to capecitabine, oxaliplatin, plus bevacizumab.
- Trial name
- NCT00120172
- Testing
- oxaliplatin, capecitabine, bevacizumab
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Geriatric Oncology Consortium
Cancer
Dyadic Life Review Intervention for Older Patients With Advanced Cancer) and Their Caregivers
The purpose of this study is to test the feasibility of a pilot Randomized Controlled Trial (RCT) comparing Dyadic Life Review (DLR) intervention in older adults with advanced cancer and their caregivers to Care-as-Usual (CAU)…
- Trial name
- DLR RCT (NCT06505122)
- Testing
- Dyadic Life Review
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
5-azacytidine Treatment Versus 5-azacytidine Followed by Allogeneic Stem Cell Transplantation in Elderly Patients With Myelodysplastic Syndrome (MDS)
5-azacytidine treatment prolongs survival in patients with myelodysplastic syndrome (MDS), but does not cure the disease. Allogeneic stem cell transplantation is a curative treatment option but is associated with a high risk…
- Trial name
- NCT01404741
- Testing
- allogeneic stem cell transplantation, 5-azacytidine until progress
- Where
- 17 sites in Germany
- Volunteers
- 191 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stomach Neoplasms, Frail Elderly
Multimodal Prehabilitation To Improve The Clinical Outcomes Of Frail Elderly Patients With Gastric Cancer
The GISSG+2201 study was launched by Shandong Gastrointestinal Surgery Study Group (GISSG). The intention is to establish a multimodal prehabilitation protocol in frail elderly patients who undergo gastric cancer radical surgery…
- Trial name
- NCT05352802
- Testing
- Multimodal prehabilitation program, ERAS protocol
- Where
- China
- Volunteers
- 368 people
- Sponsor
- The Affiliated Hospital of Qingdao University
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