Clinical trials: Elderly Cancer Patients
Ovarian Cancer
The Effectiveness of an Online Support Group in Enhancing Recovery Identity and Health-Related Quality of Life
Background Ovarian cancer poses challenges for middle-aged and older patients, impacting physical and self-conceptual aspects. A research gap exists on the impact of online support groups (SPs) on identity synthesis and…
- Trial name
- NCT06145295
- Testing
- mobile online support group (experiment group), offline support group (control group)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
75 Years Old and More, Cancer
Tool for the Detection of Oncogeriatric Fragility in Patients Aged ≥75 Years Undergoing Oncological Treatment.(D-FOG)
Many cancers are diagnosed after 75 years. Treatment in chemotherapy begins without evidence of geriatric risk factors. A new tool for screening for geriatric fragilities is used, a self-administered questionnaire carried out by…
- Conditions
- 75 Years Old and More, Cancer, Chemotherapy
- Trial name
- D-FOG (NCT03261128)
- Testing
- Self-questionnaire
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Cervical Cancers
Effect of Nurse Navigation Program on Cervical Cancer Screening Behaviour of the Women Aged 30-65
This study was designed as a randomized controlled experimental study to examine the effect of the 'Nurse Navigation Program' on cervical cancer screening behaviors (Human Papilloma Virus (HPV) DNA screening test and/or pap smear…
- Trial name
- NCT06647992
- Testing
- Nurse Navigation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TURKAN OZDAS
Lung Cancer, Gastro-intestinal Cancer
The SOAR Study: a Study of Geriatric Assessment and Exercise for Older Adults and Their Support Person
Phase 2 randomized controlled study using a waitlist control group. The study also has a single arm pre-post test 12-week chair-based exercise arm for those who have received the geriatric assessment in the older adults with…
- Conditions
- Lung Cancer, Gastro-intestinal Cancer, Genito-Urinary Cancer, Breast Cancer
- Trial name
- SOAR (NCT05509751)
- Testing
- GAM, exercise, health education, online chair-based exercise combined with health education
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Martine Puts
Elderly Patients (>65 Years), Non-Small Cell Lung Cancer
Electroacupuncture Combined With PD-1 Inhibitor for Elderly Patients With Advanced NSCLC
The goal of this clinical trial is to elucidate the clinical efficacy and safety of electroacupuncture combined with PD-1 inhibitor therapy in elderly patients with advanced non-small cell lung cancer (NSCLC) through a…
- Conditions
- Elderly Patients (>65 Years), Non-Small Cell Lung Cancer, PD-1 Inhibitors, Electroacupuncture
- Trial name
- NCT07086300
- Testing
- Electroacupuncture (EA)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Kong Fanming
Esophageal Cancer
Tislelizumab Plus Concurrent Chemoradiation in Older With ESCC
This study was conducted in elderly (≥70 years old) patients with locally advanced esophageal squamous cell carcinoma. Aim to find the difference in efficacy and safety between tirilizumab combined with concurrent chemoradiation…
- Trial name
- TCRTOE (NCT06061146)
- Testing
- Arm A, Arm B
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Cancer
An Observational Study of Avastin in First Line in Elderly Patients With Metastatic Colorectal Cancer (CASSIOPEE)
This multicenter, prospective, observational study will evaluate the efficacy and safety of Avastin (bevacizumab) in first-line therapy in elderly patients with metastatic colorectal cancer.
- Trial name
- NCT01555762
- Where
- 166 sites in France
- Volunteers
- 402 people
- Sponsor
- Hoffmann-La Roche
Acute Myeloid Leukemia (AML), Elderly Patients (60-75 Years)
VAH vs VA in Newly Diagnosed Elderly AML
This is a multicenter, open-label, randomized, controlled phase III clinical trial designed to evaluate the efficacy and safety of the combination of Venetoclax, Azacitidine, and Homoharringtonine (VAH) compared to Venetoclax and…
- Trial name
- NCT07469046
- Testing
- Venetoclax, Azacitidine, Homoharringtonine
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Esophageal Cancer, S-1
S-1 and Radiotherapy for Elderly Esophageal Cancer Patients
To investigate the efficacy and toxicity of S-1 with concurrent radiotherapy in older patients with esophageal cancer.
- Conditions
- Esophageal Cancer, S-1, Radiotherapy
- Trial name
- NCT02716688
- Testing
- S-1, radiotherapy
- Where
- China
- Sponsor
- Zhejiang Provincial People's Hospital
Locally Advanced/ Metastatic NSCLC
Observational Study With Metronomic Oral Vinorelbine in Elderly Patients With Locally Advanced / Metastatic Non-small-cell Lung Cancer (NSCLC)
Vinorelbine is the first line reference drug in the elderly patient with locally advanced / metastatic non-small-cell lung cancer (NSCLC).
- Trial name
- VINORELBINA (NCT04208854)
- Testing
- Vinorelbine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- International Group of Endovascular Oncology
Breast Cancer
Impact on Cognitive Function and Quality of Life of Adjuvant Chemotherapy in Patients Aged Over 65 Years: Application to Breast Cancer or Colon
The aim of the study is to investigate the impact of adjuvant chemotherapy on cognitive function in patients aged over 65 and suffering from breast cancer or colon.
- Trial name
- COG AGE (NCT01333735)
- Where
- 15 sites in Belgium, France
- Volunteers
- 114 people
- Sponsor
- Centre Francois Baclesse
Breast Cancer, Tumor Grade
Additional Prognostic Value of Tumor Grade Beyond the 21-gene Recurrence Score
To evaluated the prognostic significance of tumor grade in patients with node-negative, hormone receptor-positive, and human epidermal growth factor receptor 2-negative breast cancers treated according to RS-guided strategies.
- Trial name
- NCT07093775
- Testing
- Tumor grade (I or II vs. III)
- Volunteers
- 4,000 people
- Sponsor
- Gangnam Severance Hospital
Cancer (Solid Tumors), Geriatric Oncology
TRTRM (ACTTOP) -Guided Dosing Strategy in Older Patients With Cancer
Older adults receiving systemic cancer treatments are at increased risk of developing severe treatment-related toxicities (TRT).
- Trial name
- NCT07484932
- Testing
- TRTRM-guided risk-stratified treatment strategy
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Pain, Pulmonary Nodules
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use…
- Conditions
- Pain, Pulmonary Nodules, Oxycodone
- Trial name
- NCT07484867
- Testing
- oxycodone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Lung Cancer
Pneumonitis in Older Lung Cancer Patients After Radiotherapy
The main goal of this trial is to establish the performance characteristics and to develop a decision-algorithm of a new symptom-based scoring system with respect to the identification of elderly lung cancer patients developing…
- Trial name
- POLCAR (NCT06480734)
- Testing
- symptom-based scoring system (symptom-questionnaire, paper version)
- Where
- 5 sites in Denmark, Germany
- Volunteers
- 62 people
- Sponsor
- University Hospital Schleswig-Holstein
Colon Cancer, Rectal Cancer
CGA Guided Ultrafractionated RT and First-line Systemic Treatment in Elderly or Frail Patients with MCRC
This is a prospective, multicentre, cohort study. For cohort 1(CGA cohort), experimental cohort, older or Frail patients with metastatic colorectal cancer will receive Ultrafractionated Radiotherapy (RT) and Comprehensive…
- Trial name
- NCT06665087
- Testing
- Ultrafractionated RT and CGA Guided systemic treatment., Ultrafractionated Radiotherapy, PD-1 antibody
- Volunteers
- 110 people
- Sponsor
- Fudan University
Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia
Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia
This phase II trial is studying how well tipifarnib works in treating older patients with acute myeloid leukemia. Tipifarnib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Conditions
- Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia, Adult Acute Monocytic Leukemia, Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
- Trial name
- NCT01361464
- Testing
- Tipifarnib, Laboratory Biomarker Analysis
- Where
- 7 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Leukemia, Myeloid, Acute
Treatment of Non Promyelocytic Acute Myeloid Leukaemia on Elderly Patients by Low Dose Cytosar Plus Arsenic Trioxide
Our purpose in this study is to explore the feasibility of treatment of non promyelocytic Acute myeloid leukaemia on elderly patients.
- Trial name
- NCT00850304
- Testing
- Cytosar, Arsenic trioxide
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Tehran University of Medical Sciences
Multiple Myeloma
Subcutaneous Velcade Plus Oral Melphalan and Prednisone or Plus Cycloposphamide and Prednisone or Plus Prednisone
This protocol is a single-arm, three-cohort, phase II multicenter study designed to assess the safety and the efficacy of three all-oral combinations: Velcade with continuous low-dose melphalan and prednisone (VMP) or with…
- Trial name
- NCT01190787
- Testing
- velcade subcutaneous melphalan prednisone, velcade cyclophosphamide prednisone, velcade prednisone
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- European Myeloma Network B.V.
Pediatric Mental Health Services, Cancer Screening
Participatory Approaches to Qualitative Research (PAQ): Comparing Two Approaches to Patient, Public and Clinician Involvement in Qualitative Research
The goal of this trial is to compare two types of patient, public and clinician involvement (PPCI) in research: Consultative PPCI and Collaborative PPCI.
- Conditions
- Pediatric Mental Health Services, Cancer Screening, Serious Illness
- Trial name
- PAQ (NCT06838689)
- Testing
- Comparison of two standard of care regimens
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
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