Clinical trials: Elderly Cancer Patients
Breast Cancer, HER-2 Positive Breast Cancer
Chemotherapy for Elderly Patients Diagnosed With Localized HER2 Positive Breast Cancer
There is major concern regarding chemotherapy related toxicity in the group of women older than 65 years old diagnosed with human epidermal growth factor receptor 2 (HER2) positive breast cancer (BC).
- Trial name
- NCT02102438
- Testing
- Trastuzumab, Weekly Paclitaxel, Carboplatin
- Where
- Brazil
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Colorectal Neoplasms
Geriatric Intervention in Frail Elderly Patients With Colorectal Cancer
This is a randomized, controlled trial on frail elderly patients (aged 65+) with colorectal cancer. The patients will be randomized into two groups. The control group will receive standard surgical treatment.
- Trial name
- NCT01321658
- Testing
- Geriatric intervention
- Where
- Norway
- Volunteers
- 122 people
- Sponsor
- Oslo University Hospital
Lymphoma
Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or High-Grade Non-Hodgkin's Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different ways may kill more tumor cells.
- Trial name
- NCT00003113
- Testing
- filgrastim, cyclophosphamide, etoposide
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Neoplasms, Medication Adherence
A Novel E-Health Approach in Optimizing Treatment for Seniors (OPTIMUM Study)
Background: In women with hormone receptor positive (HR+) breast cancer, adjuvant endocrine therapy (AET) is associated with a significant survival advantage.
- Trial name
- NCT02876848
- Testing
- OPTIMUM e-health tool
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Gastric Cancer
A Single-arm, Phase II Exploratory Study of Sintilimab in Combination With Chemoradiotherapy in Elderly Patients With Locally Advanced Gastric Cancer
This trial is a prospective, single-arm, single-centre, phase II clinical study to explore the efficacy and safety of sintilimab in combination with chemoradiation in subjects over 75 years of age with advanced gastric cancer.
- Trial name
- NCT06555471
- Testing
- Sintilimab, S-1, Capecitabine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Non-Small Cell Lung Cancer
A Study of Tarceva (Erlotinib) in Elderly Patients With Advanced Non-Small Cell Lung Cancer
This study will compare the efficacy and safety of Tarceva (erlotinib) and vinorelbine in chemo-naive elderly patients with advanced non-small cell lung cancer.
- Trial name
- NCT01196078
- Testing
- erlotinib [Tarceva], vinorelbine
- Where
- Taiwan
- Volunteers
- 114 people
- Sponsor
- Hoffmann-La Roche
Mantle Cell Lymphoma
PirtobrUtinib as Frontline Therapy for Elderly Unfit/Frail Patient With MAntle Cell Lymphoma
This is a prospective, multicenter, phase II study, in elderly patients affected by Mantle cell lymphoma (MCL) defined as unfit/frail according to Simplified Geriatric Assessment (sGA) and previously untreated.
- Trial name
- FIL_PUMA (NCT07207785)
- Testing
- Pirtobrutinib
- Where
- 20 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs
Neuromuscular Blockade on Shoulder Pain of Elderly
Insufflation pressure (IP) is the creation of a pressure barrier of air/gas within the abdomen to allow the surgeon more space to work during abdominal surgery.
- Conditions
- Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Male Genital Organs, Malignant Neoplasms of Urinary Tract
- Trial name
- NCT03210376
- Testing
- Deep Neuromuscular Blockade (NMB), Moderate Neuromuscular Blockade (NMB), Sugammadex
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Capecitabine and Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00104689
- Testing
- capecitabine, oxaliplatin
- Where
- 9 sites in France
- Volunteers
- 60 people
- Sponsor
- UNICANCER
Acute Myelogenous Leukemia (AML)
Eltrombopag in Elderly Acute Myelogenous Leukemia (AML)
This is a phase I/II open label study being conducted to evaluate the overall safety and initial effectiveness of an investigational drug, Eltrombopag in patients who are 60 years of age and older and who have Acute Myelogenous…
- Trial name
- NCT01113502
- Testing
- Eltrombopag
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Chronic Lymphocytic Leukemia
Ruxolitinib in the Treatment of Chronic Lymphocytic Leukemia
The purpose of this study is to determine if Ruxolitinib, an inhibitor of cytokine-signaling, is effective in the treatment of patients with Chronic Lymphocytic Leukemia for whom conventional chemotherapy is either too toxic or…
- Trial name
- NCT02015208
- Testing
- Ruxolitinib
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Myeloid Leukemia
Efficacy of 5-azacytidine Added to Standard Primary Therapy in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
The primary purpose of the study is to determine, whether the addition of 5-azacytidine to standard chemotherapy in elderly patients with newly diagnosed AML improves treatment results (event free survival).
- Trial name
- AML-AZA (NCT00915252)
- Testing
- azacitidine, standard chemotherapy (7+3 scheme): Daunorubicin, Cytarabine
- Where
- 27 sites in Germany
- Volunteers
- 214 people
- Sponsor
- University Hospital Muenster
Colorectal Cancer
a Pilot Study of Lidocaine Infusion for Postoperative Analgesia in Elderly Patients With Colorectal Cancer Surgery
patients who meet the enrollment criteria will be randomized 1:1:1:1 to the different doses of lidocaine or the placebo group. In the lidocaine groups, at the beginning of surgery, lidocaine 0.5mg/kg, 1.0mg/kg, and 1.5mg/kg per…
- Trial name
- NCT05412576
- Testing
- Lidocaine Hydrochloride 2% Injection Solution, 0.9% NaCl
- Where
- China
- Volunteers
- 220 people
- Sponsor
- West China Hospital
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
MDT-Based Umbrella Decision Model for Geriatric Lung Cancer Patients
This is a single-center, prospective, single-arm interventional study with historical control, designed to evaluate the clinical value of a multidisciplinary team (MDT)-based decision-making umbrella decision model in elderly…
- Conditions
- Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Small Cell Lung Carcinoma
- Trial name
- NCT07509333
- Testing
- MDT-Based Umbrella Decision-Making Model
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- West China Hospital
Aging, Breast Cancer
The Value of Geriatric Assessments in Older Patients With Breast Cancer
Elderly cancer patients are a special group, often complicated by a variety of chronic diseases, which bring serious obstacles to surgery and adjuvant treatment.
- Conditions
- Aging, Breast Cancer, Chemotherapeutic Toxicity, Survival
- Trial name
- NCT03640117
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Lung Cancer
Ph II Gemcitabine, Erlotinib, and Gemcitabine With Erlotinib/Elderly Patients W/ IIIB/IV NSCLC
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00283244
- Testing
- erlotinib hydrochloride, gemcitabine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CLL (Chronic Lymphocytic Leukemia)
A Trial to Evaluate the Efficacy and Safety of a Fitness-adapted Thera-py Approach With Either Continuous Zanubrutinib Monotherapy or Time-limited Zanubrutinib + Sonrotoclax in Older and/or Frail Patients With Treatment-naïve CLL
The CLL-Frail2 trial will be a prospective, open-label, multicentre phase-II-trial to evaluate the efficacy and safety of a fitness-adapted therapy approach with either con-tinuous zanubrutinib (BGB-3111) monotherapy or…
- Trial name
- NCT07899398
- Testing
- Zanubrutinib, Sonrotoclax
- Volunteers
- 80 people
- Sponsor
- German CLL Study Group
Diffuse Large B Cell Lymphoma
Prospective Clinical Study of ZPR Regimen in Elderly Treatment-naive Diffuse Large B-cell Lymphoma
This is a prospective, single-arm, single-center clinical study. This clinical study aims to explore the efficacy and safety of the ZPR（Zanubrutinib, Polatuzumab vedotin and Rituximab）regimen in elderly patients with…
- Trial name
- NCT05940064
- Testing
- Zanubrutinib, Polatuzumab Vedotin, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peng Liu
Demoralization
Effects of a Five-Dimensional Intervention Program Based on Inner Strength on Demoralization Syndrome in Elderly Cancer Patients
From January 2025 to January 2026, a total of 66 elderly cancer patients with demoralization syndrome who were hospitalized in the Department of Internal Medicine at Peking Union Medical College Hospital were enrolled.
- Trial name
- NCT07625904
- Testing
- psychological support
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Leukemia
Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia in Remission
RATIONALE: Vaccines made from a peptide may help the body build an effective immune response to kill cancer cells. Colony-stimulating factors, such as GM-CSF, increase the number of white blood cells and platelets found in bone…
- Trial name
- NCT00454168
- Testing
- PR1 leukemia peptide vaccine, sargramostim
- Where
- 15 sites in United States
- Volunteers
- 244 people
- Sponsor
- The Vaccine Company
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