Clinical trials: Elderly Immune Senescence
Asthma
Safety and Efficacy Study of Fluticasone Furoate/Vilanterol (FF/VI) Fixed Dose Combination (FDC) Compared to FF Alone in Subjects With Asthma
The goal of asthma treatment is to achieve and maintain asthma control and to reduce the future risk of exacerbations. Inhaled corticosteroids (ICS) are considered as the most effective anti- inflammatory treatment for all…
- Trial name
- NCT03248128
- Testing
- FF/VI via ELLIPTA DPI, FF via ELLIPTA DPI
- Where
- 183 sites in United States, Argentina and 14 more
- Volunteers
- 906 people
- Sponsor
- GlaxoSmithKline
Sarcopenia, Sensitivity
Performance Indicators of the SARC-F Questionnaire in Acute Care
The study applies the Sluggishness, Assistance in walking, Rising from a chair, Climb stairs, Falls (SARC-F) questionnaire in older patients hospitalized in an acute care geriatric unit and aims to determine its performance…
- Conditions
- Sarcopenia, Sensitivity, Old Age; Debility
- Trial name
- SARC-F-CHUB (NCT04757454)
- Testing
- 5-item SARC-F questionnaire
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- Brugmann University Hospital
Diffuse Large B-Cell Lymphoma (DLBCL)
CRP Regimen in Treating Elderly Patients With Previously Untreated Double-Positive DLBCL
A Single-Arm, Open-Label, Multicenter Phase II Trial of CRP Regimen (Chidamide, Rituximab, Polatuzumab Vedotin) in Treating Elderly Patients with Previously Untreated Double-Positive Diffuse Large B-Cell Lymphoma
- Trial name
- NCT07397832
- Testing
- Chidamide, Rituximab, Polatuzumab Vedotin
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cognitive Disorder Patients and Cognitive Assessment
Study on the Correlation Between Treg Immune Cells on the Muscle Content and Cognitive Functions of the Elderly
In order to explore the impact of the level of the elderly Treg immune cells and the effects of different fat distribution and muscle content, the impact of the level of Treg immune cells on cognitive functions is explored.
- Trial name
- NCT06493669
- Testing
- Cognitive assessment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Asthma
Pharmacokinetic Profile and Safety of Fluticasone Propionate and Albuterol Sulfate in Combination When Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Children Aged 4 to 11 Years Old
The primary objectives of this study are: To determine the pharmacokinetic (PK) profile of fluticasone propionate (Fp) and albuterol sulfate (ABS), delivered in combination, from a single dose of TEV-56248 (Fp and ABS multidose…
- Trial name
- NCT06290102
- Testing
- TEV-56248, Fp MDPI
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Multiple Sclerosis, Relapsing-Remitting
A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis
This study will evaluate the safety, tolerability, and descriptive efficacy of BIIB017 in pediatric participants with relapsing-remitting multiple sclerosis (RRMS) and to assess the pharmacokinetics (PK) of BIIB017 in pediatric…
- Trial name
- NCT03958877
- Testing
- BIIB017 (peginterferon beta-1a), Interferon beta type 1a
- Where
- 65 sites in United States, Argentina and 20 more
- Volunteers
- 152 people
- Sponsor
- Biogen
Chemotherapy, Diffuse Large B-Cell Lymphoma (DLBCL), Nos
Assessment of Survival and Autonomy With Rituximab Plus Chemotherapy or Rituximab Plus Lenalidomide for Elderly Patients With Relapsed Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Annual incidence increases with age and achieves more than 30 per 100 000 patients 65 years old or over.
- Conditions
- Chemotherapy, Diffuse Large B-Cell Lymphoma (DLBCL), Nos, Elderly
- Trial name
- Relyage (NCT04113226)
- Testing
- Rituximab, Lenalidomide 20 MG, Comprehensive Geriatric Assessment (CGA)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Asthma
Efficacy and Safety Study of Mepolizumab 100 Milligram (mg) Subcutaneous (SC) in Indian Participants Aged Greater Than or Equal to (>=) 18 Years With Severe Eosinophilic Asthma
Mepolizumab is a humanized monoclonal antibody (IgG1, kappa) that blocks interleukin- 5 (IL-5) thus inhibits production and survival of eosinophils.
- Trial name
- PRISM (NCT04276233)
- Testing
- Mepolizumab, Salbutamol
- Where
- 14 sites in India
- Volunteers
- 100 people
- Sponsor
- GlaxoSmithKline
Influenza
Safety Study of Four Candidate Influenza Vaccines to Prevent Influenza Disease in the Elderly Population
As influenza vaccine efficacy is reported to be lower in elderly subjects compared to healthy adults, probably as a result of immunosenescence, there is a desire to devise ways to increase the current vaccines efficacy for this…
- Trial name
- NCT00318149
- Testing
- Fluarix, Fluarix-AS25, Fluarix-AS50
- Where
- Belgium
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Arthritis, Rheumatoid
Study Of 90mg Of GW274150 In Subjects Over 50 Years, Who Have Rheumatoid Arthritis (RA)
This is a study of GW274150, an iNOS (inducible nitric oxide synthase) inhibitor to investigate safety, tolerability and pharmacokinetics (PK) in the rheumatoid arthritis (RA) population (greater than 50 years).
- Trial name
- NCT00370435
- Testing
- GW274150
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- GlaxoSmithKline
Acute Lymphocytic Leukemia
Allo CART-19 Protocol
The primary objective is to determine the safety and survival of the redirected allogeneic T cells transduced with the anti-CD19 lentiviral vector (referred to as CART-19 cells).
- Trial name
- NCT01551043
- Testing
- CART-19
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Asthma (Diagnosis), Children
Asthma Health Literacy Scale for Children (AHLSC) (Aged 8-12)
Asthma Health Literacy Scale for Children (AHLCS) (Ages 8-12): A Scale Development Study Objective: This study will be conducted using a methodological design to develop and examine the psychometric properties of the Asthma…
- Conditions
- Asthma (Diagnosis), Children, Health Literacy, Scale Reliability Validity
- Trial name
- NCT07295249
- Testing
- Asthma Health Literacy Scale for Children (AHLSC) (Aged 8-12): A Scale Development Study
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Lymphocytic Leukemia, Chronic
A Study of MabThera/Rituxan (Rituximab) in Combination With Fludarabine And Cyclophosphamide as Primary Therapy in Elderly Patients With Chronic Lymphocytic Leukemia
This single arm, open-label study will assess the safety and efficacy of low dose fludarabine and cyclophosphamide in combination with standard dose MabThera/Rituxan (rituximab) as primary therapy in elderly patients (>/= 65…
- Trial name
- NCT01263704
- Testing
- Cyclophosphamide, Fludarabine, Rituximab
- Where
- 12 sites in Israel
- Volunteers
- 42 people
- Sponsor
- Hoffmann-La Roche
Influenza
Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine (CAIV-T) in Healthy Children
To perform a variety of assays on blood, nasal washes, and cells obtained from healthy children for the purposes of further investigation of immune responses generated by influenza virus vaccine, trivalent, types A and B, live…
- Trial name
- CAIVT (NCT00192322)
- Testing
- CAIV-T 10^7, CAIVT 10^5, TIV
- Where
- 2 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Acute Lymphocytic Leukemia
Treatment of Philadelphia-Positive Acute Lymphocytic Leukemia (Ph+ ALL) in the Elderly With Imatinib Mesylate (STI571) and Chemotherapy.
ALL patients aged 55 years or older were treated with steroids during one week and Ph+ve cases were then offered a specific therapy including an induction treatment with steroids, cyclophosphamide, daunorubicin and vincristine…
- Trial name
- NCT00149136
- Testing
- imatinib
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Influenza
Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine,(CAIV-T)
The primary objective of this study was to perform a variety of immunological assays on blood, serum, nasal wash samples, and cells obtained from healthy adult subjects for the purpose of developing assays for application in the…
- Trial name
- NCT00192231
- Testing
- CAIV-T
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Atopic Dermatitis
Evaluation of an Adapted Formula on Atopic Dermatitis.
The aim of this study is to show the efficiency of a new infant formula containing fiber on the management of moderate to severe atopic dermatitis.
- Trial name
- NCT05318300
- Testing
- tested formula with fiber, Control
- Where
- 3 sites in Belgium, France
- Volunteers
- 126 people
- Sponsor
- United Pharmaceuticals
Atopic Dermatitis
Assessment of Efficacy of the Consumption of a Heat-treated Lactobacillus Paracasei (GM080) on Atopic Dermatitis
The primary objective of this trial is to assess the efficacy of the consumption of heat-treated Lactobacillus paracasei (GM080) on atopic dermatitis as compared to a placebo treatment.
- Trial name
- NCT02103972
- Testing
- GM080, Maltodextrin
- Where
- 6 sites in Taiwan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Multiple Myeloma de Novo Treatment
Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/Maintenance Treatment in Young and Elderly Patients : 3 Randomized Studies.
The aim of the study was to evaluate efficacy and tolerability of Thalidomide in first-line treatment of multiple myeloma as induction treatment in young patients, with Dexamethasone before autotransplant, and in elderly patients…
- Trial name
- MAG 2002 (NCT01070862)
- Testing
- Thalidomide, Dexamethasone, Vincristin , Adriamycin, Dexamethasone = VAD, Thalidomide, melphalan, endoxan, dexamethasone (MCDex-Thal)
- Where
- 3 sites in France
- Sponsor
- University Hospital, Caen
Hand, Foot and Mouth Disease
Lot-to-lot Consistency Study of Three Commercial Batches of Enterovirus 71 Vaccine
This study is a randomized, blinded study to evaluate the lot-to-lot consistency of immunogenicity, safety, and immune persistence of three consecutive manufacturing lots of EV71 vaccine, in 1500 children aged 6-35 months.
- Trial name
- NCT06146088
- Testing
- EV71 Vaccine
- Where
- 4 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences