Clinical trials: Electric Countershock
Atrial Fibrillation
Amiodarone Compared to Dronedarone , Post Cardioversion Maintenance of Sinus Rhythm
Persistent Atrial Fibrillation (AF) is a common and distressing cardiac arrhythmia and accounts for 1% of the healthcare budget in the UK and it's prevalence is rising.
- Trial name
- ACDC (NCT01266681)
- Testing
- amiodarone, Dronedarone
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- East Sussex Healthcare NHS Trust
VF, VT
Defibrio AED Study
The purpose of this research is to test an investigational device called the Defibrio AED (automated external defibrillator). The researchers are conducting the study to determine if the Defibrio AED is safe to use and is able to…
- Trial name
- NCT07880873
- Testing
- treatment with Defibrio AED
- Volunteers
- 25 people
- Sponsor
- Defibrio, LLC
Atrial Fibrillation, Cardioversion
Optimization of Initial Energy for Cardioversion of Atrial Fibrillation With Biphasic Shocks
Use of higher energy doses (120-150 J) may not offer additional benefits and higher success rate compared with low to moderate initial energy (100-120 J) of biphasic shock for atrial fibrillation cardioversion.
- Trial name
- OPTIMA (NCT01910779)
- Testing
- 100 joule as first biphasic shock energy, 120 joule as first biphasic shock energy
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Maria Vittoria Hospital
Atrial Fibrillation Paroxysmal, Coronary Artery Disease Without Residual Ischemia
Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia
Current guidelines for the cardioversion of paroxysmal Atrial Fibrillation at the Emergency Department do not prioritize between antiarrhythmic agents and do not consider the time taken for successful cardioversion.
- Trial name
- FLECA-ED (NCT05549752)
- Testing
- Flecainide Injectable Solution, Amiodarone Injectable Solution
- Where
- 3 sites in Greece
- Volunteers
- 80 people
- Sponsor
- Hippocration General Hospital
Atrial Fibrillation
D-Dimer-based Indication for Transesophageal Echocardiography to Exclude Left Atrial Thrombus Before Cardioversion of Non-anticoagulated Atrial Fibrillation: A Multicenter Belgian Study
This trial aims at evaluating the number of thromboembolic events post cardioversion in patients receiving a direct current cardioversion with either prior transesophageal echocardiography or D-Dimer (DD) analysis.
- Trial name
- CARDDI-BEL (NCT04784039)
- Testing
- Transesophageal echocardiography, D-Dimer analysis
- Volunteers
- 1,368 people
- Sponsor
- AZ Sint-Jan AV
Ventricular Arrhythmias
Acute Defibrillation Study
The proposed study is designed to characterize defibrillation efficacy in humans for the potential development of a new extravascular implantable cardioverter defibrillator (ICD) system.
- Trial name
- NCT02227121
- Testing
- Defibrillation following induction of VT/VF
- Where
- 7 sites in Hong Kong, Netherlands and 2 more
- Volunteers
- 16 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation (AF)
Evaluation of Probiotics' Effect on Atrial Fibrillation Recurrence in Patients Undergoing Cardioversion
The aim of this clinical study is to evaluate the efficacy and tolerability of probiotics on atrial fibrillation recurrence.
- Trial name
- NCT07568964
- Testing
- Anticoagulant Therapy, Probiotics capsules
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Ain Shams University
Atrial Fibrillation, Coffee
Does Eliminating Coffee Avoid Fibrillation?
Given both the increasing population impact of atrial fibrillation (AF) and the widespread consumption of coffee in society, determining an associated benefit or risk of coffee consumption on AF is of great clinical relevance.
- Trial name
- DECAF (NCT05121519)
- Testing
- Consume coffee, Avoid coffee
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Persisent Atrial Fibrillation, Reversal of Atrial Enlargement
Left Atrial Volume Changes Who Underwent Cardioversion and Recurrence of AF After RF Ablation in Persistent AF (SAFE-AF)
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesize that persistent atrial fibrillation (AF) patients with more significant left atrial size reduction after cardioversion have…
- Conditions
- Persisent Atrial Fibrillation, Reversal of Atrial Enlargement, Recurrence of Atrial Fibrillation
- Trial name
- SAFE-AF-ABL (NCT06523738)
- Testing
- 1. electrical/pharmacological cardioversion. 2.pulmonary vein isolation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Atrial Fibrillation, Atrial Flutter
Trial of Electrical Versus Pharmacological Cardioversion for RAFF in the ED
Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac rhythm problems where there is an irregular, rapid heart rate. Investigators plan to study Emergency Department (ED) patients with recent-onset episodes of AF or AFL…
- Trial name
- RAFF-2 (NCT01891058)
- Testing
- drug-shock vs shock only
- Where
- 10 sites in Canada
- Volunteers
- 396 people
- Sponsor
- Ottawa Hospital Research Institute
Atrial Fibrillation
Inflammation as a Predictor in Cardioversion of Atrial Fibrillation
The laboratory test, C-Reactive Protein (CRP), has become well established as a marker of inflammation. Recently a high CRP level (indicating an increase in inflammation) was identified as a risk factor for atrial fibrillation.
- Trial name
- NCT00590525
- Testing
- Cardioversion
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Creighton University
Ventricular Tachyarrhythmia
Lead EvaluAtion for Defibrillation and Reliability (LEADR) / Lead Evaluation for Defibrillation and Reliability in Left Bundle Branch Area Pacing (LEADR LBBAP)
The LEADR study is designed to assess the safety and efficacy of the Next Generation ICD lead. The LEADR LBBAP study is being conducted under the existing US FDA Investigational Device Exemption (IDE) for the Next Generation ICD…
- Trial name
- NCT04863664
- Testing
- Defibrillation (RV Implant), Defibrillation (LBBAP Implant)
- Where
- 55 sites in United States, Australia and 18 more
- Volunteers
- 1,007 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Ventricular Arrhythmia, Ventricular Tachycardia
Sensing and Defibrillation With a Commercially Available ICD Coupled With a Parasternal Extravascular Lead (SECURE EV) Study
The SECURE EV Study is a prospective, multi-center, single-arm study without concurrent or historical controls. The objectives of the study are 1) to characterize safety of the AtaCor EV-ICD Lead up to 90 days post-implant, and…
- Conditions
- Ventricular Arrhythmia, Ventricular Tachycardia, Ventricular Fibrillation
- Trial name
- SECURE EV (NCT05352776)
- Testing
- AtaCor EV-ICD Lead
- Where
- Paraguay
- Volunteers
- 18 people
- Sponsor
- AtaCor Medical, Inc.
Ventricular Arrhythmia, Ventricular Tachycardia
Parasternal Access for ShockS and Pacing With an acUtely Placed Less-invasive Lead for EV-ICD (PASS PULL EV-ICD) Study
The PASS PULL EV-ICD Study is a prospective, multi-center, single-arm study without concurrent or historical controls. This initial concept feasibility study is primarily intended to demonstrate that the EV-ICD Lead can be safely…
- Conditions
- Ventricular Arrhythmia, Ventricular Tachycardia, Ventricular Fibrillation
- Trial name
- PASS PULL (NCT05099289)
- Testing
- AtaCor EV-ICD Lead
- Where
- Paraguay
- Volunteers
- 18 people
- Sponsor
- AtaCor Medical, Inc.
Atrial Fibrillation
Device-based Rate Versus Rhythm Control in Symptomatic Recent-onset Atrial Fibrillation (RACE 9 OBSERVE-AF)
Continuous heart rhythm monitoring elucidated the recurrent and transient nature of recent-onset atrial fibrillation (AF). The RACE7 ACWAS showed that a wait-and-see approach (WAS) in patients with recent-onset AF (rate control…
- Trial name
- NCT04612335
- Testing
- Rate control, Pharmacological or electrical cardioversion
- Where
- 14 sites in Netherlands
- Volunteers
- 490 people
- Sponsor
- Maastricht University Medical Center
Cardiovascular Diseases
A Comparison of Conventional Adult Out-of-hospital Cardiopulmonary Resuscitation Against a Concept With Mechanical Chest Compressions and Simultaneous Defibrillation - LINC Study
The primary objective is to show superiority in survival of the modified method with the LUCAS Chest Compression System, compared to the conventional manual resuscitation method in patients suffering from out of hospital sudden…
- Trial name
- LINC (NCT00609778)
- Testing
- LUCAS, Conventional manual resuscitation method
- Where
- 6 sites in Netherlands, Sweden and 1 more
- Volunteers
- 2,500 people
- Sponsor
- Jolife AB
Atrial Fibrillation
Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation
The purpose of this study is to compare which strategy is superior in patients with persistent/permanent atrial fibrillation (AF) undergoing ablation, direct current cardioversion (DCC) prior to empirical pulmonary vein isolation…
- Trial name
- NCT02429648
- Testing
- DCC first then PVI, PVI then DCC after
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation Fluttering
Ankle - Brachial Index Measurement in Atrial Fibrillation
Consecutive patients with atrial fibrillation will be admitted to the hospital for electrical cardioversion. Ankle brachial index will be measured three times with oscillometric method and three times with doppler method.
- Trial name
- AFABI (NCT02986282)
- Testing
- ABI measurement using both doppler and oscillometric method
- Volunteers
- 115 people
- Sponsor
- Medical University of Warsaw
Atrial Fibrillation, Atrial Flutter
Comparison of Oxygen Interventions and Defibrillator Efficiency
Background: Cardiac arrhythmias can be terminated by electrical current applied by an external defibrillator. This treatment, named cardioversion, has been used for decades in the treatment of atrial fibrillation.
- Trial name
- CODE (NCT02317029)
- Testing
- Cardioversion with a pulsed biphasic waveform, Normoxia during cardioversion, Cardioversion with a biphasic truncated exponential waveform
- Where
- Denmark
- Volunteers
- 134 people
- Sponsor
- Randers Regional Hospital