Clinical trials: Electrical Stimulation of the Brain
Migraine Disorders
tDCS for the Treatment of Migraine
The aim of this study is to evaluate an optimized protocol of tDCS that normalize the lack of habituation and efficiency of inhibitory cortical circuits in migraine patients.
- Trial name
- NCT02562196
- Testing
- tdcs
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Parkinson's Disease
Transcutaneous Electrical Nerve Stimulation (TENS) for Lower Urinary Tract Disorders in Parkinson's Syndrome
Only one study has evaluated the effect of TENS in LUTD in Parkinson's syndromes. It was reported at the congress of the "Société Interdisciplinaire Francophone d'UroDynamique et de Pelvi-Perinéologie" (SIFUD-PP) in 2011 by…
- Trial name
- UROPARKTENS (NCT02190851)
- Testing
- TENS, Control
- Where
- 11 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Toulouse
Cerebrovascular Accident
Analysis of the Electrical Muscle Activity and Resistance to Movement in Spastic Hemiparetic Patients.
To evaluate and compare the effects of Neuromuscular Electrical Stimulation when applied in the agonist and antagonist muscles of spastic hemiparetic patients.
- Trial name
- EENM (NCT01945151)
- Testing
- Group 2 (G2) NMES is applied in the spastic muscle (gastrocnemius).
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Universidade do Vale do Paraíba
Stroke
Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke
This clinical trial will evaluate if Deep Brain Stimulation (DBS) is safe for the treatment of stroke and will help understand if DBS improves motor recovery for patients who continue to have significant impairment.
- Trial name
- EDEN (NCT02835443)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Enspire DBS Therapy, Inc.
Movement Disorders, Effect of Remifentanil
Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation
Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients.
- Trial name
- NCT00588926
- Testing
- Remifentanil
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Stroke
Muscle Coordination-Based Feedback for Stroke Rehabilitation
The purpose of this study is to compare two interventions currently used to improve gait and lower limb function in individuals with chronic stroke (i.e., high-intensity gait training and high-intensity gait training with…
- Trial name
- NCT06099444
- Testing
- Conventional High Intensity Gait Training, Standard FES to the Tibialis Anterior (TA), Synergy-Based Multichannel FES (MFES)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Cerebrovascular Stroke, Muscle Weakness
Cold Therapy and Cross-Education of Muscle Strength
The aim of this study is to investigate whether a cold application to the contralateral (affected side) extremity in addition to unilateral neuromuscular electrical stimulation (NMES) application has a facilitating effect on…
- Trial name
- NCT04886843
- Testing
- Cold pack, NMES
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Aphasia, TBI (Traumatic Brain Injury)
Electrical Stimulation in Traumatic Brain Injury (TBI) Induced Aphasia
The aim of this study is to investigate whether a tDCS-accompanied intensive naming therapy leads to a performance improvement in patients with chronic aphasia induced by a moderate TBI
- Conditions
- Aphasia, TBI (Traumatic Brain Injury), tDCS
- Trial name
- NCT03882502
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Medicine Greifswald
Stroke
Study on the Effects of an EMG-controlled Functional Electrical Stimulator for Upper Limb for Post-stroke Patients
Upper limb disabilities are among the most debilitating issues after a cerebral stroke. One promising approach in motor rehabilitation is the use of functional electrical stimulation (FES).
- Trial name
- NCT06928857
- Testing
- EMG-based FES rehabilitation, Traditional rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Treatment Resistant Depression, Depressive Disorder
A Clinical Evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression
This is a randomized, placebo-controlled double-blind cross-over trial evaluating the safety, efficacy, daily functioning, and health-related quality of life of Subcallosal Cingulate Gyrus Deep Brain Stimulation (SCG DBS) for…
- Trial name
- NCT01801319
- Testing
- Libra Deep Brain Stimulation System
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Abbott Medical Devices
Cognition, Attention
Neurocognitive Basis of Attention and Eye Movement Guidance in the Real World Scenes
The objective of this study is to determine the effects of electrical brain stimulation (EBS) on visual search in natural scenes in humans.
- Conditions
- Cognition, Attention, Eye Movements
- Trial name
- NCT04652856
- Testing
- Electrical Brain Stimulation
- Where
- United States
- Sponsor
- Avniel Ghuman
Stroke
High-definition Transcranial Electrical Stimulation for Upper Extremity Rehabilitation
Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct current or alternating current to change the excitability of the cerebral cortex.
- Trial name
- NCT04278105
- Testing
- HD-tCES, Upper extremity rehabilitation
- Where
- 3 sites in Taiwan
- Volunteers
- 24 people
- Sponsor
- Taipei Medical University
Spastic Cerebral Palsy (sCP)
Biomechanical and Functional Effects of Adding Sensory-Threshold Electrical Stimulation to Neurodevelopmental Therapy in Children With Spastic Cerebral Palsy: A Single-Arm Repeated-Measures Study
This study investigates whether adding sensory-level electrical stimulation to an ongoing neurodevelopmental treatment program is associated with changes in ankle mobility, spasticity-related measures, muscle mechanical…
- Trial name
- NCT07491341
- Testing
- Sensory Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Harran University
Stroke Patients With Hemiplegia or Hemiparesis in the Subacute Stage
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke)
The goal of this study is to evaluate the effects of high frequency tPCS + TENS compared to Sham device stimulation + TENS (Control) in lower limb motor function recovery in stroke patients with hemiplegia or hemiparesis in the…
- Trial name
- COMPENSATOR (NCT06999876)
- Testing
- The AscenZ-VIII Stimulator (Investigational Medical Device)
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- National University Health System, Singapore
Parkinson Disease
Effects of Peripheral Electrical Stimulation With Focused Ultrasound on Motor Symptoms in Parkinson's Patients
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as small as a few cubic…
- Trial name
- tbFUS-FES_PD (NCT06090292)
- Testing
- Real TUS, Real FES
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Parkinson's Disease
The Role of Cerebellar Hyperactivity in Parkinson's Disease
Gait and balance disturbances are one of the most incapacitating symptoms of Parkinson's disease (PD) (Boonstra et al. 2008). They can cause falls and are therefore associated with the negative spiral of (near) falls, fear of…
- Trial name
- NCT02349789
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Peripheral Facial Palsy, Pulsed Radiofrequency
Non-Invasive Brain-Computer Interface Combined With Transcranial Electrical Stimulation for Peripheral Facial PalsyStimulation in the Treatment of Peripheral Facial Palsy
To evaluate the efficacy and safety of treating peripheral facial palsy using a non-invasive brain-computer interface combined with transcranial direct current stimulation (tDCS).
- Conditions
- Peripheral Facial Palsy, Pulsed Radiofrequency, Brain-Computer Interface, Transcranial Direct Current Stimulation
- Trial name
- NCT07327710
- Testing
- Brain-Computer Interface （BCI）, Pulsed Radiofrequency （PRF）, Standard Therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing Medical University
Epilepsy
An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
The overall goal of this project is to better understand the micro-physiology of human epilepsy and cognition using the intracranial electroencephalogram (iEEG), electrical brain stimulation, functional magnetic resonance imaging…
- Trial name
- NCT00859794
- Testing
- fMRI, Neuropsychological Testing, Additional electrode implantation
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Northwell Health
Ischaemic Stroke
The RETRAIN Trial (Phase 1)
The primary objective is to investigate in stroke patients the impact of geko™ NMES treatment, when used as standard of care for VTE prevention, on brain haemodynamics at different stimulation levels and in three different…
- Trial name
- RETRAIN (NCT06614400)
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Countess of Chester NHS Foundation Trust
Epilepsy
Evaluation of Direct Effects of Electric Fields on Brain
Transcranial current stimulation (tCS), a safe, tolerable technique employing weak currents (~ 1 mA) applied to the scalp, has been shown to be a promising technique in alleviating seizures in focal epilepsy patients.
- Trial name
- GALVANI PS-2 (NCT05250713)
- Testing
- Transcranial stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique Hopitaux De Marseille