Clinical trials: Electroconvulsive Therapy
Depression, Major Depressive Episode
Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults
To evaluate the feasibility, tolerability and efficacy of Magnetic Seizure Therapy (MST) in elderly patients with a major depressive episode, who are randomly assigned to receive an acute course of MST or ECT.
- Conditions
- Depression, Major Depressive Episode, Bipolar Disorder
- Trial name
- MSTvsEST (NCT01869374)
- Testing
- MagVenture MagPro MST, RUL ECT
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Episode, ECT
Metabolomics During ElectroConvulsivoTherapy
Investigators will measure the variation of blood Metabolome through 1H NMR at several time points during the course of electroconvulsivetherapy in patients with a major depressive episode.
- Trial name
- METECT (NCT05973643)
- Testing
- Electroconvulsive therapy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hôpital le Vinatier
Mental Disorders
Effects of Pretreatment With Ibuprofen in Post-Electroconvulsive Therapy (ECT) Headache
The purpose of the study is to determine whether ibuprofen reduces post-ECT headache or reduces its severity.
- Trial name
- NCT00258791
- Testing
- Ibuprofen
- Sponsor
- Norwegian University of Science and Technology
Depression
The Antidepressive Effect of rTMS as add-on to ECT
The aim of the present study is to investigate in which degree low frequency right prefrontal rTMS used ad add-on may potentiate the antidepressant effect of unilateral ECT and accelerate remission .
- Trial name
- TMS (NCT02123485)
- Testing
- Low frequency (1 hz) rTMS, as add-on to ECT
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus
Depression
The Effects of ECT and/or iTBS on Olfaction and Cognition in Patients With Depression
The sense of smell and cognition are known to be closely associated with mood and emotional processes. However, despite the clear links between olfaction and cognitive processes with emotional states, research into the role of…
- Trial name
- NCT02804347
- Testing
- Cognitive Function Imaging and Battery, Sniffin Sticks, Cognitive Batteries
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen's University
Depression
Understanding How Anaesthesia Affects ECT Outcomes
This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus…
- Trial name
- NCT03105245
- Testing
- Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
- Where
- Australia
- Volunteers
- 54 people
- Sponsor
- The University of New South Wales
Depression
Neurorestorative Effects of Electroconvulsive Therapy (ECT) in Patients With Severe Late Life Depression
To study the potential neurorestorative effects of electroconvulsive therapy (ECT) in depressed patients by measuring brain derived neurotrophic factor (BDNF) serum levels and hippocampal volumes in severely depressed patients…
- Trial name
- NCT02667353
- Testing
- ECT, Etomidate, Succinylcholine
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Treatment Resistant Depression, Major Depressive Disorder
Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression
In this proof of concept study, the investigators plan to administer iv ketamine interleaved with ECT days. Patients with treatment resistant depression who are deemed to be eligible for ECT treatment will randomly be assigned to…
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT02522377
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Cleveland Clinic
Memory, Short-Term
Ginkgo Biloba to Improve Short-Term Memory Losses Associated With Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is an effective treatment for severe or medication-resistant depression and other psychiatric disorders. A common side effect of ECT is problems with short-term memory during treatment.
- Trial name
- NCT00070954
- Testing
- ginkgo biloba
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Depression, Intracranial Pressure
Regulation of Intracerebral Pressure During Electroconvulsive Therapy
The purpose of this study is to determine whether electroconvulsive therapy (ECT) has an influence on pressure within the human brain before, during and after ECT.
- Trial name
- NCT00597831
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Rijnstate Hospital
Bipolar Depression
Accelerated LFR for Bipolar Patients During the COVID-19 Pandemic
The current study aims to assess the feasibility, acceptance and clinical outcomes of a practical high-dose LFR protocol, including tapering treatments and symptom-based relapse prevention treatments, in patients with bipolar…
- Trial name
- NCT04427137
- Testing
- MagPro X100 Stimulator, B70 Fluid-Cooled Coil
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Centre for Addiction and Mental Health
Hemodynamic Response
Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is a treatment modality that induces therapeutic seizures through electrical stimulation for the management of certain psychiatric disorders.
- Trial name
- NCT07824817
- Testing
- Saline (0.9% NaCl), Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Inonu University
Bipolar Disorder, Manic
Magnetic Seizure Therapy vs. Electroconvulsive Therapy for Bipolar Mania
This trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (MST) and its safety for bipolar mania. Half of the participants will receive MST, while the other half will receive electroconvulsive therapy…
- Trial name
- NCT03016104
- Testing
- Magpro X100 + Option, ThymatronSystem Ⅳ Electroconvulsive System, treatment as usual (TAU)
- Where
- China
- Sponsor
- Shanghai Mental Health Center
Major Depression
Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7)
The main purpose of this study is to investigate the relapse preventing efficacy of escitalopram in a dose range and nortriptylin in a single dose in patients having been treated successfully with a course of electroconvulsive…
- Trial name
- DUAG-7 (NCT00660062)
- Testing
- escitalopram, nortriptyline
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Hillerod Hospital, Denmark
Epilepsy, Depression
Measuring Blood Flow in the Brain After Epileptic Activity
In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT).
- Conditions
- Epilepsy, Depression, Postictal Delirium, Electroconvulsive Therapy
- Trial name
- SYNAPSE (NCT04028596)
- Testing
- Paracetamol, Nimotop
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Rijnstate Hospital
Depressive Disorder, Bipolar Disorder
Multimodal Biomarkers of Electroconvulsive Therapy in Severe and Treatment-resistant Depression
Electroconvulsive therapy (ECT) is a widespread and safe stimulation method that has been used successfully for decades in psychiatric diseases such as severe or therapy-resistant depression.
- Trial name
- DetECT (NCT05463562)
- Where
- Germany
- Volunteers
- 134 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Esketamine, ECT
Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
The study design was a randomized, double blind, parallel controlled trial.The goal of this clinical trial is to learn if esketamine-assisted modified electroconvulsive therapy (ESK-MECT) works to treat severe depression in…
- Conditions
- Esketamine, ECT, Depression, Adolescent
- Trial name
- NCT07247968
- Testing
- Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume)
- Where
- 2 sites in China
- Volunteers
- 220 people
- Sponsor
- Min Su