Clinical trials: Electroconvulsive Therapy (ECT)
Major Depressive Disorder, Magnetic Resonance Imaging
Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With Depression: a Multicenter Prospective Cohort Study
The aim of this project is to investigate the multimodal magnetic resonance brain imaging changes in adolescents with major depressive disorder (MDD) before and after electroconvulsive therapy.
- Conditions
- Major Depressive Disorder, Magnetic Resonance Imaging, Electroconvulsive Therapy
- Trial name
- NCT05889234
- Testing
- Modified Electroconvulsive Therapy, Conventional pharmacotherapy
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Blood Pressure, Electroconvulsive Therapy
Pre-medication With Alfentanil vs Placebo During ECT
Hemodynamic changes associated with the conduct of electroconvulsive therapy may be minimized with the administration of alfentanil as part of their anesthetic regimen.
- Trial name
- NCT03359395
- Testing
- Alfentanil
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Depression
Comparison of Three Electroconvulsive Therapy (ECT) Techniques for the Treatment of Major Depression
This study will compare the antidepressant benefits and cognitive side effects of three different types of electroconvulsive therapy (ECT) in people with unipolar or bipolar depression.
- Trial name
- NCT00069407
- Testing
- Electroconvulsive Therapy
- Where
- 4 sites in United States
- Volunteers
- 230 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Depression
The Antidepressive Effect of rTMS as add-on to ECT
The aim of the present study is to investigate in which degree low frequency right prefrontal rTMS used ad add-on may potentiate the antidepressant effect of unilateral ECT and accelerate remission .
- Trial name
- TMS (NCT02123485)
- Testing
- Low frequency (1 hz) rTMS, as add-on to ECT
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus
Depression, Mania
Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and the Development of Protective Antibodies
Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%).
- Conditions
- Depression, Mania, Hallucinations
- Trial name
- SismoSens (NCT05210062)
- Testing
- Iterative exposure to suxamethonium during ECT sessions
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Bipolar, Depression, Unipolar
The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)
This study will determine the effectiveness and safety of S-Ketamine in depression patients undergoing electroconvulsive therapy.
- Conditions
- Depression, Bipolar, Depression, Unipolar, Major Depressive Disorder, Manic-Depressive - Now Depressed
- Trial name
- ECT (NCT04399070)
- Testing
- S-ketamine, ketamine, saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Yan Qiu
Depressive Episode, Electroconvulsive Therapy
Electroconvulsive Treatment Followed by Cognitive Control Training
Major depressive disorder (MDD) is worldwide one of the most prevalent and disabling mental health conditions. Electroconvulsive therapy (ECT) is a safe and effective treatment even though 6-month relapse rates are high.
- Conditions
- Depressive Episode, Electroconvulsive Therapy, Cognitive Remediation
- Trial name
- ECT-CCT (NCT04383509)
- Testing
- Cognitive Control Training, Active Control
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Ghent
Depressive Episode, Electroconvulsive Therapy
RCT for Electroconvulsive Treatment Followed by Cognitive Control Training
Major depressive disorder (MDD) is worldwide one of the most prevalent and disabling mental health conditions. Electroconvulsive therapy (ECT) is a safe and effective treatment even though 6-month relapse rates are high.
- Conditions
- Depressive Episode, Electroconvulsive Therapy, Cognitive Remediation
- Trial name
- ECT-CCT (NCT05683028)
- Testing
- Cognitive Control Training, Active Control
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent
Depression
ECT/Succinylcholine: Biochemical, Serum and Cardiovascular Changes
This study will be conducted to determine the pharmacodynamics, cardiovascular and biochemical effects of succinylcholine when given during electroconvulsive therapy. (ECT).
- Trial name
- NCT00750906
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
Depression
Ketamine Anesthesia in Electroconvulsive Therapy
Does the use of ketamine as the anesthetic medication in electroconvulsive therapy (ECT) accelerate the antidepressant effect of ECT? The study hypothesis was that depressed subjects receiving ECT with ketamine as the anesthetic…
- Trial name
- NCT01367119
- Testing
- Ketamine, methohexital
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Schizophrenia, Schizoaffective Disorder
Electroconvulsive Therapy in Clozapine-resistant Schizophrenia
Electroconvulsive therapy (ECT) is one of the oldest neuromodulation treatments still used in psychiatry. Only case reports and open label non-randomized studies have been published of ECT in clozapine-resistant schizophrenia…
- Trial name
- NCT02159001
- Testing
- electroconvulsive therapy
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Niuvanniemi Hospital
ECT, Treatment Resistant Depression
CET- REM (Correlating ECT Response to EEG Markers)
Single-center study to determine the relationship between changes in depression symptoms and electroencephalographic (EEG) patterns induced by electroconvulsive therapy (ECT)
- Trial name
- NCT04451135
- Testing
- Electroencephalographic (EEG), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Ictal Electroencephalographic (EEG) Measurements
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Neurocognition
Translational Research Evaluating Neurocognitive Memory Processes
The purpose of this study is to evaluate the psychometric properties and utility of new, computerized, neurocognitive measures in humans with depression, and humans with depression undergoing electroconvulsive therapy (ECT).
- Trial name
- TREC-MP (NCT01834677)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Duke University
Depression
Changing Tactics? Optimizing ECT in Difficult-to-treat Depression
The goal of this randomized controlled trial is to address which treatment strategy (continue right unilateral (RUL) ECT or switch to bitemporal (BT) ECT speeds up recovery and has the least impact on memory function, in case of…
- Trial name
- ChaT (NCT05923801)
- Testing
- switch to BT electrode position, continue with RUL electrode position
- Where
- Belgium
- Volunteers
- 196 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Major Depressive Disorder, Bipolar Disorder
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
- Trial name
- NCT05172271
- Testing
- MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Clinical Trial on Efficacy of rTMS to Improve ECT in Treatment-Resistant Depression
It's a prospective, multicentric, randomized, controlled study concerning 56 patients with treatment-resistant depression (TRD).
- Trial name
- STIMAGNECT (NCT02830399)
- Testing
- active rTMS-ECT
- Where
- 3 sites in France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier du Rouvray
Depressive Disorder, Major
Randomised Controlled Trial of Electroconvulsive Therapy (ECT) in Relapse Prevention of Depression
The purpose of the study is to determine if continuation electroconvulsive therapy (ECT) is safe and effective in relapse prevention of depression.
- Trial name
- NCT00627887
- Testing
- Electroconvulsive therapy, venlafaxine, Lithium
- Where
- 4 sites in Sweden
- Volunteers
- 56 people
- Sponsor
- Örebro County Council
Electroconvulsive Therapy, Major Depressive Disorder
Impact of Covid-19 Pandemic on Patients Receiving Continuation or Maintenance Electroconvulsive Therapy
Electroconvulsive therapy is a safe and effective therapeutic strategy in patients with treatment resistant depression. As relapse after successful ECT is significant even with adequate pharmacological strategies, continuation…
- Conditions
- Electroconvulsive Therapy, Major Depressive Disorder, Covid-19
- Trial name
- COVID-M-ECT (NCT05633368)
- Testing
- Questionnaires
- Where
- 2 sites in Belgium
- Volunteers
- 47 people
- Sponsor
- University Hospital, Ghent
Severe Depression
Brain Changes in Severely Depressed Patients Before and After Treatment With Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is a non-pharmacological treatment used in resistant depression whose effectiveness has been demonstrated. However, the brain mechanisms underlying this therapeutic effect remain unclear.
- Trial name
- ECT-IM (NCT02715986)
- Testing
- 3T MRI
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Toulouse