Clinical trials: Electroconvulsive Therapy (ECT)
Major Depressive Disorder, Bipolar Depression
Pulse Width 0.15ms vs 0.30ms in Electroconvulsive Therapy
The PWECT015 study was designed to compare the application of 0.15ms and 0.30ms pulse width in electroconvulsive therapy (ECT). Subjects will be compared both within groups and in-group via psychometric scales.
- Trial name
- PWECT015 (NCT05465915)
- Testing
- Electroconvulsive therapy
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Neuromuscular Blockade
Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)
The investigators propose to compare the recovery of neuromuscular blockade from rocuronium reversal by sugammadex to succinylcholine in ECT.
- Trial name
- CRoSSECT (NCT03532178)
- Testing
- Group A. "Muscle relaxant #1": rocuronium + sugammadex; "Muscle relaxant #2": succinylcholine +saline, Group B. "Muscle relaxant #2": succinylcholine +saline; "Muscle relaxant #1": rocuronium + sugammadex;
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Treatment Resistant Depression, Major Depressive Disorder
ECT vs. Esketamine
Treatment-resistant depression (TRD) is a common cause of disability and one of the most common psychiatric disorders worldwide. Electroconvulsive therapy (ECT) is currently the most effective treatment for TRD.
- Trial name
- ETES (NCT04924257)
- Testing
- Esketamine nasal spray, Electroconvulsive therapy
- Where
- Austria
- Sponsor
- Medical University Innsbruck
Depression
Ketamine Interleaved With Electroconvulsive Therapy for Depression
Pragmatic, randomised, controlled, parallel group, pilot clinical trial of ketamine vs. midazolam interleaved with electroconvulsive therapy (ECT) as an adjunctive treatment for a major depressive episode.
- Trial name
- NCT04082858
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 3 people
- Sponsor
- St Patrick's Hospital, Ireland
Major Depression, Bipolar Depression
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
The primary objectives of this study are to investigate the potential for ketamine anesthesia to increase the antidepressant efficacy of Electroconvulsive therapy (ECT) and to decrease acute ECT-induced adverse cognitive effects.
- Trial name
- NCT01309581
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- James Murrough
Electroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA)
ECCA's Turkish Validity and Reliability Study and Comparison With Other Cognitive Assessment Tests
Electroconvulsive therapy (ECT) is one of the oldest biological treatment methods used in psychiatry, based on inducing widespread seizures in the brain with externally applied controlled electrical currents.
- Conditions
- Electroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA), Montreal Cognitive Assessment (MoCA), Turkish Adaptation
- Trial name
- NCT07527234
- Testing
- ElectroConvulsive Therapy Cognitive Assessment (ECCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Pamukkale University
Major Depressive Disorder, Bipolar Disorder II
Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT
Cognitive problems, like memory loss, are common after brain injuries like trauma or stroke. These problems make daily life harder, and the investigators don't yet know the best ways to help the brain recover.
- Trial name
- LTP-DUCIECT (NCT06733558)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Sponsor
- University of New Mexico
Depression, Depressive Disorder
Optimizing Electroconvulsive Therapy for Depression
This study will evaluate the effectiveness of electroconvulsive therapy (ECT) administered with medication for the treatment of a major depressive episode (unipolar or bipolar) and will compare two types of ECT.
- Conditions
- Depression, Depressive Disorder, Bipolar Disorder
- Trial name
- NCT00045916
- Testing
- High dosage electroconvulsive therapy, Nortriptyline, Venlafaxine
- Where
- 4 sites in United States
- Volunteers
- 340 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive Therapy
This randomized controlled trial will compare two anesthetic agents, propofol and ketofol (a combination of propofol and ketamine), in patients undergoing electroconvulsive therapy (ECT).
- Trial name
- NCT07273851
- Testing
- Propofol, Ketofol
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Fauji Foundation Hospital
Depression
Understanding How Anaesthesia Affects ECT Outcomes
This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus…
- Trial name
- NCT03105245
- Testing
- Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
- Where
- Australia
- Volunteers
- 54 people
- Sponsor
- The University of New South Wales
Depressive Disorder, Depression
Exploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI Study
The main purpose of this study is to determine whether electroconvulsive therapy (ECT) causes any structural or functional brain changes and thus indicating its mechanism of action.
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major
- Trial name
- NCT03040388
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- University of Copenhagen
Major Depressive Disorder, Bipolar Depression
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
This study aims to compare the efficacy and safety profile of Magnetic Seizure Therapy and Electroconvulsive therapy.
- Trial name
- EMCODE (NCT05054699)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Unipolar Depression, Bipolar Depression
Mechanism of Action of Electroconvulsive Therapy
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
- Trial name
- MoA-ECT (NCT04059952)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Temporomandibular Joint Dysfunction Syndrome, Tooth Injuries
Effectiveness of Three Oral Devices as Mouthguard in Electroconvulsive Therapy. Randomized Crossover Clinical Trial.
This observer-blind crossover intervention study aims to determine the most effective type of device as oral mouthguard in modified-Electroconvulsive Therapy (m-ECT) comparing three types of devices: standard, prefabricated and…
- Conditions
- Temporomandibular Joint Dysfunction Syndrome, Tooth Injuries, Dental Occlusion, Traumatic
- Trial name
- NCT02678715
- Testing
- Solubrux®, Customized Appliance, Somatics®
- Where
- Spain
- Volunteers
- 4 people
- Sponsor
- Eva Willaert Jiménez-Pajarero
Depressive Disorder
Evaluating the Efficacy of Magnetic Seizure Therapy in Treatment Resistant Depression.
Electroconvulsive therapy (ECT) has unparalleled efficacy in treating severe depression that is resistant to common modalities of treatment, such as antidepressant medication.
- Trial name
- NCT01748708
- Testing
- Magnetic seizure therapy, Electroconvulsive therapy
- Where
- Canada
- Sponsor
- Centre for Addiction and Mental Health
Depressive Symptoms, Impaired Cognition
Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is an effective treatment for depression compared with the current antidepressant agents，but the most important side effect is cognitive dysfunction.
- Conditions
- Depressive Symptoms, Impaired Cognition, Electroconvulsive Therapy
- Trial name
- NCT02305394
- Testing
- ketamine and propofol, propofol and normal saline
- Where
- China
- Volunteers
- 132 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Memory, Short-Term
Ginkgo Biloba to Improve Short-Term Memory Losses Associated With Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is an effective treatment for severe or medication-resistant depression and other psychiatric disorders. A common side effect of ECT is problems with short-term memory during treatment.
- Trial name
- NCT00070954
- Testing
- ginkgo biloba
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Depression, Delirium
Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
This study is geared toward characterizing the recovery of brain activity and cognitive function following treatments of electroconvulsive therapy and ketamine general anesthesia.
- Conditions
- Depression, Delirium, Seizures, Cognitive Disorders
- Trial name
- RCC2 (NCT02761330)
- Testing
- Ketamine, Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Blood Pressure, Electroconvulsive Therapy
Pre-medication With Alfentanil vs Placebo During ECT
Hemodynamic changes associated with the conduct of electroconvulsive therapy may be minimized with the administration of alfentanil as part of their anesthetic regimen.
- Trial name
- NCT03359395
- Testing
- Alfentanil
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Depressive Episode, Electroconvulsive Therapy
RCT for Electroconvulsive Treatment Followed by Cognitive Control Training
Major depressive disorder (MDD) is worldwide one of the most prevalent and disabling mental health conditions. Electroconvulsive therapy (ECT) is a safe and effective treatment even though 6-month relapse rates are high.
- Conditions
- Depressive Episode, Electroconvulsive Therapy, Cognitive Remediation
- Trial name
- ECT-CCT (NCT05683028)
- Testing
- Cognitive Control Training, Active Control
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent