Clinical trials: Electrocorticography
Sleep, Neuromodulation
The Effect of Thalamic Stimulation on Sleep Oscillations
The thalamus plays a key role in supporting sleep and is also a target of therapeutic stimulation. This project investigates when, where, and how electrical stimulation delivered to the thalamus in humans elicits or disrupts…
- Trial name
- NCT07217080
- Testing
- Effect of Electrical Stimulation on Sleep
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Drug Resistant Epilepsy, Brain-Computer Interfaces
StereoEEG Motor Neuronal Potentials Decoding
The goals of this study are (1) to evaluate the rate of stereoEEG brain-computer interface (BCI) classification accuracy and (2) to collect the dataset of neuronal signals recorded from stereoEEG electrodes during motor…
- Trial name
- NCT06432907
- Testing
- motor tasks
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Research Center of Neurology, Russia
Brain Injury, Neurosurgery
Electrocorticographic Monitoring of Brain Retraction Injury (EMBRI)
A single centre IDEAL Stage 1 feasibility study using novel electrophysiological recording techniques in adult participants undergoing neurosurgery.
- Conditions
- Brain Injury, Neurosurgery, Brain Ischemia
- Trial name
- EMBRI (NCT06409806)
- Testing
- ECOG Array
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Brain Tumor, Glioma
FIH Clinical Investigation of Graphene Electrodes for Brain Mapping
The goal of this clinical investigation of a medical device is to test the safety of graphene based electrodes when used during surgery for resection of brain tumors.
- Trial name
- NCT06368310
- Testing
- INBRAIN Graphene Cortical Interface
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Manchester
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital
Epilepsy, Brain Tumor
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG).
- Trial name
- ECOG-Anaes (NCT07165262)
- Testing
- Fentanyl (IV), Ketamine (0.5 mg/kg)
- Where
- 2 sites in Egypt
- Volunteers
- 88 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Tumor, Brain
Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation
Elucidating the structure-function relationship of the brain is one of the main open questions in neuroscience. The capabilities of diffusion MRI-based (dMRI) techniques to quantify the connectivity strength between brain areas…
- Trial name
- NCT03503110
- Testing
- electrocorticography with electrostimulation, dRMI
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cognition, Attention
Neurocognitive Basis of Attention and Eye Movement Guidance in the Real World Scenes
The objective of this study is to determine the effects of electrical brain stimulation (EBS) on visual search in natural scenes in humans.
- Conditions
- Cognition, Attention, Eye Movements
- Trial name
- NCT04652856
- Testing
- Electrical Brain Stimulation
- Where
- United States
- Sponsor
- Avniel Ghuman
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Social Influence, Epilepsy
Effects of Social Feedback on Intracranial EEG
This study aims to assess the impact of social influence on direct neural recordings in human patients undergoing surgical treatment of epilepsy.
- Trial name
- NCT06975800
- Testing
- Low social feedback, High social feedback
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Trustees of Dartmouth College
Epilepsy
The Role of Intracranial Electroencephalography (IEEG) in the Localization of Epileptogenic Zones (EZ) and Its Relationship With Prognosis
The mechanism of epilepsy pathogenesis is complex and not fully defined, and about 20-30% of patients with seizures that cannot be completely controlled by drugs become drug-resistant epilepsy.
- Trial name
- NCT05443958
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Refractory Localization-related Epilepsy
A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
Epilepsy occurs in 0.5-0.7% of the population, of which 25% are children. 30% Of patients with focal epilepsy do not respond well to medication and half of them are eligible for epilepsy surgery.
- Trial name
- NCT02207673
- Testing
- Tailoring of the resection based on biomarker in aEcoG during epilepsy surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Low Grade Glioma of Brain
Measure of the Potential Evoked by Electric Stimulation
This study is about an experimental biomedical monocentric search concerning twelves patients presenting a infiltrative glioma of low rank OMS type II and realizing a surgery awakened on the site of the CHU of Montpellier.
- Trial name
- PE&CE (NCT02509442)
- Testing
- Diffusion of direct electric stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Epilepsy, Healthy Volunteers
Simultaneous MEG or fMRI And INtracranial EEG
The SEMAINE project will investigate intracranial EEG (icEEG) simultaneously recorded with either fMRI or MEG to 1) improve identification of the epileptogenic zone in patients suffering from drug-resistant partial epilepsy, and…
- Trial name
- SEMAINE (NCT02342938)
- Testing
- MEG or fMRI And INtracranial EEG, fMRI
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cognitive Impairment, Dementia
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for…
- Conditions
- Cognitive Impairment, Dementia, ADD, Depression
- Trial name
- NCT05927974
- Testing
- Passive testing, Active testing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Aphasia, Dysarthria
Chinese-Specific Speech Imagery Coding Using High-Density ECoG
The goal of this study is to investigate whether high-density electrocorticography (ECoG) signals recorded from the surface of the brain can be used to decode neural representations of Mandarin Chinese speech features, including…
- Conditions
- Aphasia, Dysarthria, ALS, Speech and Language Disorder
- Trial name
- NCT07460037
- Testing
- Intraoperative high-density ECoG recording, Permanent high-density ECoG implantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aphasia
Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography
This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts.
- Trial name
- NCT04620928
- Testing
- Concepts
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
Tetraplegia, Spinal Cord Injury
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
The purpose of this research study is to demonstrate that individuals with upper limb paralysis due to spinal cord injury, brachial plexus injury, amyotrophic lateral sclerosis and brain stem stroke can successfully achieve…
- Conditions
- Tetraplegia, Spinal Cord Injury, Brachial Plexus Injury, Muscular Dystrophy
- Trial name
- NCT01393444
- Testing
- Implantation of ECoG sensors on the brain surface
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Epilepsy Intractable
TMS - Intracranial Electrodes
This is a study looking at the effects of transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation (NIBS), on the human brain as recorded by intracranial electroencephalography in neurosurgical patients.
- Trial name
- NCT03702127
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aaron Boes
Epilepsy, Brain Tumor Adult
Neuronal and Network Mechanisms of Electrocortical Stimulation
Electrocortical stimulation (ECS) mapping is a procedure used during brain surgeries, for example when treating diseases like epilepsy or when removing brain tumors.
- Trial name
- NCT06391294
- Testing
- Focal cortical cooling
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Northwestern University