Clinical trials: Electronic Cigarettes
Oxidative Stress, Tobacco Use
Impact of Electronic Cigarette Temperature and Solvent on Biomarkers
This project seeks to determine how e-cigarette (EC) physical design features, including those that allow the user to manipulate the quality and quantity of aerosols, affect exposure and toxicity from oxidants and other aerosol…
- Conditions
- Oxidative Stress, Tobacco Use, Electronic Cigarettes
- Trial name
- NCT07612696
- Testing
- High temperature wattage setting on electronic cigarette, Low temperature wattage setting on electronic cigarette, High concentration of Propylene Glycol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Smoking, Nicotine Dependence
Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults
This is a pilot human experimental study to evaluate whether the use of an e-cigarette affects lung function, exhaled CO levels, and quantitative tobacco cigarette consumption in active tobacco smokers.
- Trial name
- NCT02498145
- Testing
- Nicotine e-cigarette, Non-nicotine e-cigarette
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Nicotine Dependence
E-Cigarettes and SNA
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
- Trial name
- NCT02724241
- Testing
- one time exposure to e-cig with nicotine, One time exposure to e-cigarette without nicotine, one time exposure to empty e-cigarette
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
E-Cig Use, Adolescent Behavior
Identifying Student Opinion Leaders to Lead E-cigarette Interventions
This research will explore the feasibility of leveraging social network analysis to identify 6th grade opinion leaders to lead a school-based e-cigarette intervention.
- Trial name
- NCT04083469
- Testing
- Peer-Led Peer-Elected Intervention, Adult-Led Intervention, Peer-Led Non-Elected Intervention
- Where
- United States
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Tobacco Abuse Smoke
Pharmacokinetic Profile of Toxic Substances and Nicotine in Electronic Cigarettes
The aim of the present study is to compare serum nicotine levels of different e-Cigarette strength with usual cigarettes. Serum levels of carcinogenic and toxic substances will be also compared.
- Trial name
- KINECIG (NCT01665066)
- Testing
- Own Brand cigarette, one high 2,4% nicotine, original 7,4 mg nicotine
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Catania
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Smoking, Healthy Participants
Investigation of the Impact of Smoking Status on Allergen-induced Nasal Airway Inflammation Using a Cat Hair (Felis Domesticus) Extract Nasal Allergen Challenge Model
The purpose of this pilot study is to evaluate allergen-induced nasal airway inflammation following nasal application of felis domesticus, or cat, extract in e-cigarette users, cigarette smokers, and non-smokers.
- Conditions
- Tobacco Smoking, Healthy Participants, E-cigarette Smokers
- Trial name
- Kitty Nose (NCT03031145)
- Testing
- Felis Domesticus
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tobacco Smoking, Psychiatric Disorders
The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment
This study aims to establish the feasibility and acceptability of a project designed to investigate the impact of electronic cigarette use on combustible cigarette smoking and smoking-related factors among smokers with…
- Trial name
- NCT04014322
- Testing
- E-cigarette
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fordham University
Smoking Cessation
Effectiveness of Different THR Products in Adult Population
The study is a two-arm, parallel randomized controlled trial (RCT) with a treatment period of 12 weeks, and long-term follow-up at 52 weeks which plans to enroll 258 smokers from general adult population.
- Trial name
- NCT05825924
- Testing
- E-Cigarette, Nicotine patch
- Where
- Pakistan
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Foundation for a Smoke Free World INC
Diabete Type 2, E Cigarette Use
Switching to E-Cigarettes After Type 2 Diabetes Diagnosis and Health Outcomes
Individuals with T2DM who smoke have higher risks of cardiovascular disease and other complications. Many people consider e-cigarette as a "harm-reduction" alternatives to combustible cigarettes, but it is not clear whether…
- Conditions
- Diabete Type 2, E Cigarette Use, Clinical Outcomes
- Trial name
- E-cig-DM (NCT07414355)
- Testing
- Change in smoking behavior after type 2 diabetes diagnosis
- Where
- South Korea
- Volunteers
- 133,320 people
- Sponsor
- Samsung Medical Center
Cigarette Smoking, E-Cigarette Use
Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
The purpose of this research study is to understand whether concurrent treatment for cigarettes and e-cigarettes in which an individual quits both products at the same time (QUIT-C) or sequential treatment in which an individual…
- Conditions
- Cigarette Smoking, E-Cigarette Use, Smoking Cessation
- Trial name
- NCT06027840
- Testing
- Varenicline, Counseling, Guided Self-Change Booklets
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Cigarette Smoking Behavior, E-Cigarette Use
Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.
This pilot randomized trial tested whether switching to e-cigarettes, compared with standard nicotine replacement therapy (NRT; patch and gum), helped adults with a history of chronic homelessness stop smoking combustible…
- Trial name
- ESHIFT (NCT07897058)
- Testing
- E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Thomas Jefferson University
Smoking
CSD170302: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes
To determine the rate and amount of nicotine uptake with 10-minute ad libitum use of four different marketed electronic cigarettes.
- Trial name
- NCT03233997
- Testing
- FT21018, FT21033, FT21034
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-2 (NCT04449510)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Electronic Cigarette Use
Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)
The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users.
- Trial name
- NCT05971823
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
Background: Smoking is a difficult habit to quit, and some people find it more difficult to quit than others do. Nicotine is the substance in cigarettes that makes smoking so addictive.
- Trial name
- NCT01867411
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three menthol electronic cigarettes…
- Trial name
- NCT02664012
- Testing
- Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Smoking, Asthma
E-cigarettes for Harm Reduction in Adults With Asthma
Smoking is the main cause of preventable disease and death in the US and impacts respiratory illnesses including COPD and asthma.
- Conditions
- Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- SWAP (NCT05278065)
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brown University
Pulmonary Disease, Chronic Obstructive, Cigarette Smoking
E-Visit for COPD and Smoking Cessation
The goal of this work is to develop, refine, and pilot test an electronic visit (e-visit) to: 1) deliver smoking cessation treatment to adults at risk for COPD and 2) to improve rates of COPD early detection and accurate…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Cigarette Smoking, Telemedicine
- Trial name
- NCT04155073
- Testing
- smoking cessation, early COPD detection, electronic visit, Treatment As Usual
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Medical University of South Carolina
Cigarette Smoking
E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services
This randomized controlled trial evaluated the feasibility and potential efficacy of 1) e-cigarette switching (EC) or 2) e-cigarette switching + financial incentives for combustible cigarette cessation (EC+FI)
- Trial name
- EXCHANGE (NCT03743532)
- Testing
- E-cigarette Switching, Financial Incentives
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma