Clinical trials: Electrophysiology
Inherited Arrhythmias and Valvulopathies
Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells
The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the…
- Trial name
- Diag-iPS (NCT01734356)
- Testing
- Skin biopsies
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Depressive Symptoms
Efficacy and Biological Targets of Response to rTMS Therapy in Youth Depression
Youth depression is a debilitating disorder that exacts enormous social, economic and personal cost. Unfortunately, treatments which are conventionally used to treat adult depression have often modest to no efficacy in youth and…
- Trial name
- NCT02472470
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Healthy Volunteers
Genetic Sources of Variability of the Adaptation of the Ventricular Repolarisation
The main objective is to research for genetic factors involved in the extreme modifications of the QT interval of the electrocardiogram in answer to a pharmacological stimulation (sotalol) and physiological stimulation in the…
- Trial name
- Generepol (NCT00773201)
- Testing
- Sotalol 80 mg
- Where
- France
- Volunteers
- 997 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Use Disorder
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
Background: Chronic heavy drinking can cause alcohol use disorder (AUD). AUD changes how the brain works. People with AUD may drink compulsively or feel like they cannot control their alcohol use.
- Trial name
- NCT06269627
- Testing
- Acamprosate calcium
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Peripheral Neuropathy Associated With Anti-myelin Associated Glycoprotein Antibodies (Anti-MAG Neuropathy)
Use of QTRAC Technique to Measure Axonal Excitability in Anti-MAG Neuropathy
The QTRAC method is an electrophysiological technique that assesses peripheral nerve axonal excitability, using computerized analysis of the muscular response of musculus abductor pollicis brevis, to series of electrical…
- Trial name
- EXCIMAG (NCT02468596)
- Testing
- QTRAC assessment, Clinical assessment of peripheral nerve function
- Where
- 8 sites in France
- Volunteers
- 6 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cochlear Implant
Subjective and Objective Results With CI Electrode Types
Background The authors' aim was to compare the influence of various electrode designs on selected objective and subjective clinical outcomes for cochlear implant recipients using the same model of receiver-stimulator, Cochlear™…
- Trial name
- NCT03515473
- Testing
- cochlear implant
- Where
- Hungary
- Volunteers
- 139 people
- Sponsor
- Szeged University
Thromboembolism, Deep Vein Thrombosis
DVT After Cardiac Procedure
Patients undergoing electrophysiology studies (EPS) and cardiac ablation procedure for the treatment of cardiac arrhythmias may be at increased risk of deep vein thrombosis (DVT) during or after the procedure, which may lead to…
- Trial name
- NCT03877770
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Manchester University NHS Foundation Trust
OCD, Tic Disorders
Objective Characterizatoion of Repetitive Behaviors
Introduction: Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in…
- Conditions
- OCD, Tic Disorders, Gilles de la Tourette Syndrome
- Trial name
- NCT06050369
- Testing
- EEG, MRI
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Spinal Cord Disease
Combination of Multiparametric MRI and Electrophysiology for the Development of New Biomarkers in Spinal Cord Diseases
The spinal cord is a common site for the development of several neurodegenerative neurological disorders (spinal muscular atrophy or SMA, amyotrophic lateral sclerosis or ALS, X-linked spinal bulbar muscular atrophy or SBMA).
- Trial name
- SPINE2 (NCT02885870)
- Testing
- Combination of multiparametric MRI and electrophysiology
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche sur la Moelle épinière et l'Encéphale
Myofascial Trigger Points
A Clinical Observation on Neuropsychology and Electrophysiology in Headache Patinets With Myofascial Trigger Points
To study the clinical characteristics of headache patients with pericranial myofascial trigger points(MTrPs),and to explore the possible pathogenesis of MTrPs,investigators hope to find the possible electrical biomarkers for…
- Trial name
- NCT03082547
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Fear, PTSD
Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
This study aims to specifically examine the in vivo electrophysiology and effects of direct stimulation of the human amygdala during conditioned and evoked fear.
- Conditions
- Fear, PTSD, Panic Disorder
- Trial name
- NCT03958903
- Testing
- Amygdala recording and stimulation using Neuropace RNS, Behavioral tasks
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Atrioventricular Nodal Reentry Tachycardia, Supraventricular Tachycardia (SVT)
3D Mapping Versus Conventional Ablation in AVNRT
This prospective randomized interventional study compared conventional fluoroscopy-guided slow pathway ablation versus three-dimensional electroanatomical mapping-guided ablation in patients with electrophysiologically confirmed…
- Trial name
- MAP-AVNRT (NCT07630480)
- Testing
- Conventional Slow Pathway Ablation, 3D Electroanatomical Mapping-Guided Ablation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Sensorineural Hearing Loss, Bilateral
Factors Affecting Early Progress of Cochlear Implant Outcomes in Adults
The aim of this study is to understand how audiometric, cognitive and electrophysiological results relate to sentence recognition score in adults using currently a Nucleus cochlear implant.
- Trial name
- PROGRESS (NCT05265260)
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Cochlear
Hypercapnia
Trancutaneous Monitoring to Avoid Hypercapnea During Complex Catheter Ablations
Use of trancutaneous CO2 (TC02) monitoring to aide in titration of sedation of midazolam and fentanyl. Trancutaneous readings validated with invasively obtained specimens from existing arterial sheaths required during AF and VT…
- Trial name
- TCO2 (NCT01815034)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Healthy Volunteer
A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects
This study is a Phase 1, randomized, double-blind, placebo-controlled study of multiple doses of SAGE-718 using ketamine challenge to evaluate the electrophysiology, safety, tolerability, and pharmacokinetics in healthy subjects.
- Trial name
- NCT03844906
- Testing
- SAGE-718
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Atrial Fibrillation, Stroke
Philips Intracardiac Echocardiography (ICE) Clinical Registry
The purpose of this observational registry is to report real-world safety and performance of VeriSight for ultrasound guided ICE imaging in percutaneous cardiac intervention procedures when used in standard clinical practice.
- Conditions
- Atrial Fibrillation, Stroke, Valve Disease, Heart, Atrial Septal Defect
- Trial name
- NCT04950192
- Testing
- ICE Image guidance
- Where
- 5 sites in United States
- Volunteers
- 155 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Tachycardia, Supraventricular, Tachycardia, Ventricular
Accuracy and Safety Study of the Magnetecs CGCI System for Intracardiac Mapping
The Magnetecs Catheter Guidance Control and Imaging (CGCI) system is a magnetic remote navigation system which is comprised of a magnetic chamber of eight electromagnets around the patient torso.
- Trial name
- RICTAM (NCT01222156)
- Testing
- Remote magnetic navigation, Magnetecs Catheter Guidance Control and Imaging system
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Magnetecs Corporation
Parkinson's Disease With Freezing of Gait
Neurophysiological Dissection and Intervention of Freezing of Gait in Parkinson's Disease
Different conditions of gait ignition freezing, spontaneous freezing during walking and turning freezing on encountering obstacle will be investigated in fMRI study to examine whether different regions of brain will be involved…
- Trial name
- NCT03127475
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- China Medical University Hospital
Amyotrophic Lateral Sclerosis
Electrophysiology and Ultrasound of Respiratory Muscles and Respective Nerves to Predict Respiratory Insufficiency in ALS
Respiratory insufficiency is a common complication in amyotrophic lateral sclerosis (ALS). Survival can be prolonged with noninvasive ventilation (NIV).
- Trial name
- NCT06841341
- Testing
- electromyography, ultrasonography, Arterial blood gas analysis
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Jagiellonian University