Clinical trials: Electrophysiology
Lewy Body Disease
Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease
Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood.
- Trial name
- DYNAPATH-LB (NCT07335692)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Ventricular Tachycardia
Modification of the Local Abnormal Ventricular Activity Only
Local abnormal ventricular activity (LAVA) is composed of high-frequency, mainly low voltage signals that represent near-field signals from slow-conducting tissue and thus potential VT isthmuses.
- Trial name
- LAVAONLY (NCT05331716)
- Testing
- Cardiac ablation therapy
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University of Kiel
Ultrasound, Muscle Disease
Role of Ultrasound in Diagnosis of Muscle Diseases
The study aims to provide a timely update on the role of combining clinical and neuromuscular ultrasound assessments in diagnosis and follow-up of various muscle diseases in clinical practice over 12 months period, and…
- Trial name
- NCT04233255
- Testing
- Neuromuscular Ultrasound (US), Electrophysiological studies, Seum CPK, CK-MM levels, Lactate dehydrogenase and alanine aminotransferase.
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Assiut University
Premature Ejaculation
Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research
An observational study on the effect of new classification for premature ejaculation.
- Trial name
- NCT02572037
- Where
- 6 sites in China
- Volunteers
- 568 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Parkinson Disease
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus…
- Trial name
- NCT06234995
- Testing
- Levodopa, Clinical DBS Setting, DBS Setting Maximizing Prefrontal Activation
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Deep Brain Stimulation Surgery, Electrophysiology
Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp…
- Conditions
- Deep Brain Stimulation Surgery, Electrophysiology, General Anesthesia, Consciousness, Loss of
- Trial name
- NCT06400901
- Testing
- No interventions
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
ADHD - Attention Deficit Disorder With Hyperactivity
Brain Stimulation and Attention Control in Children With ADHD
The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control.
- Trial name
- NCT07182344
- Testing
- Intermittent Theta Burst Stimulation to Right DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Congenital Disorders
Biventricular Pacing in the Pediatric Population
Hypothesis 1 (H1): Epicardial biventricular pacing is a safe and feasible method of pacing in young patients. Over the last two years, physicians at Children's Healthcare of Atlanta have been implanting epicardial BiV pacing…
- Trial name
- NCT00267423
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Healthcare of Atlanta
Alcohol Use Disorder
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
Background: Chronic heavy drinking can cause alcohol use disorder (AUD). AUD changes how the brain works. People with AUD may drink compulsively or feel like they cannot control their alcohol use.
- Trial name
- NCT06269627
- Testing
- Acamprosate calcium
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Vibration, Electrophysiology
Developing Optimal Focal Muscle Vibration for Improving Spasticity
The overall aim of the proposed study is to determine optimal parameter of focal muscle vibration for improving spasticity and identify neurophysiological mechanism in healthy subjects.
- Conditions
- Vibration, Electrophysiology, Muscle Spasticity
- Trial name
- NCT01915342
- Testing
- Focal muscular vibration
- Where
- South Korea
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Coma
Improving Awakening Prognostication After Non Anoxic Coma Using PET-MRI in Intensive Care Unit
In last decades, several advances in the neuro-intensive management have lead to decrease mortality in Intensive Care Units. A significant morbidity remains as patients survive after a traumatic coma with uncertain quality of…
- Trial name
- ETIC (NCT02798588)
- Testing
- PET-MRI
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Catheterization, Radiation Exposure
Reduce Radiation Exposure in Fluoroscopic Interventions Evaluation
The purpose of this study is to determine whether the ControlRad system device when installed in Fluoroscopic (x-ray) machine reduces radiation dose to operators (Doctors and nurses) and to the patient who is undergoing cardiac…
- Trial name
- REDEFINE (NCT04404257)
- Testing
- ControlRad System, Without ControlRad System
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Corewell Health East
Cochlear Implant
Subjective and Objective Results With CI Electrode Types
Background The authors' aim was to compare the influence of various electrode designs on selected objective and subjective clinical outcomes for cochlear implant recipients using the same model of receiver-stimulator, Cochlear™…
- Trial name
- NCT03515473
- Testing
- cochlear implant
- Where
- Hungary
- Volunteers
- 139 people
- Sponsor
- Szeged University
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Post-TAVI
Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm
The replacement of the aortic valve by percutaneous approach (called TAVI) is a therapy which is booming in the management of aortic stenosis.
- Trial name
- LBBB-TAVI (NCT02482844)
- Testing
- pacemaker implantation, holter implantation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Major Depressive Disorder
Electrophysiologic Parameters and Biomarkers Predicting Treatment Response in Patients With Major Depressive Disorder
To explore electrophysiologic parameters and biomarkers predicting treatment response of patients with major depressive disorder To explore electrophysiologic parameters and biomarkers predicting suicide risk of patients with…
- Trial name
- NCT01997580
- Testing
- escitalopram
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Conscious Sedation During Procedure, Ablation of Arrhythmias
Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation
Complex procedures for treatment of cardiac arrhythmias are usually performed under deep sedation, since a quiet position of the patient is usually required over several hours and a significant risk of injury is caused by…
- Trial name
- TRACES (NCT04038476)
- Testing
- Standard monitoring + transcutaneous CO2 monitoring, Standard monitoring
- Where
- Germany
- Volunteers
- 726 people
- Sponsor
- University of Ulm
Healthy
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
This research study will use computerized tasks, electroencephalography (EEG), and magnetic resonance imaging (MRI) to look at how the drug psilocybin, a naturally occurring compound contained in hundreds of species of…
- Trial name
- NCT05301608
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Major Depressive Disorder, Epilepsy
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is…
- Trial name
- NCT05996900
- Testing
- Intracranial electrodes, TMS
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Stanford University
Atrial Fibrillation, Hypertension
Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers
The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent…
- Trial name
- NCT00225667
- Testing
- Irbesartan
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Connolly, Stuart, M.D.