Clinical trials: Elevated Blood Sugar
Hyperglycemia
Investigating the Role of the Polyol Pathway in the Central Nervous System
Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia.
- Trial name
- NCT02272556
- Testing
- Brain MRS during hyperglycemic clamp, Analysis of Metabolites in cerebrospinal fluid
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Yale University
Pre-diabetes
Anti-hyperglycemic Effect of Short-term Arginyl-fructose Supplementation in Subjects With Pre-diabetes and Newly Diagnosed Type 2 Diabetes: Randomized, Double-blinded, Placebo-controlled Trial.
In this double-blind, placebo-controlled study, subjects with prediabetes and type 2 diabetes were randomly assigned to the placebo control group or the test (Arginyl-fructose: AF) group.
- Trial name
- NCT02285231
- Testing
- Arginyl-fructose
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Pre-diabetes
Short-term Health Effects of Wild Blueberry Juice Consumption
Researchers at the University of Prince Edward Island want to learn about the health effects of wild blueberry juice.
- Trial name
- NCT02139878
- Testing
- Wild blueberry juice
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Sleep Apnea, Pre-diabetes
Mechanisms of Prediabetic States in Sleep Apnea
The purpose of this study is to better understand how sleep apnea contributes to the development of diabetes.
- Trial name
- NCT04234217
- Testing
- Continuous positive airway pressure, Niacin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Hyperglycemia, Insulin Sensitivity
Effect of Prebiotics on Blood Glucose Management
This survey is designed to investigate the effect of highland barley β-glucan supplementation on the regulatory of blood glucose, gut microbiota and cardiovascular risk fators in subjects with hyperglycemia.
- Trial name
- NCT04636489
- Testing
- Highland barley β-glucan dietary supplement
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Healthy, Pre-diabetic
The Effect of Acute Lysine Administration on α-aminoadipic Acid
This study aims to assess the effect and breakdown of lysine administration, specifically examining whether it leads to increased plasma 2-AAA in healthy humans.
- Trial name
- NCT02756117
- Testing
- L-Lysine, Normal (0.9%) Saline
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Type 1 Diabetes Mellitus, Sleep Quality
Safety and Effectiveness of the Luna System in People With Type 1 Diabetes Mellitus
The purpose of this research is to evaluate the effect of a wearable insulin pump on blood sugar levels during sleep. The study device works with continuous glucose monitors (CGM) to calculate and deliver rapid-acting insulin…
- Trial name
- AID4MDI (NCT06627517)
- Testing
- Episodic overnight patch pump
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Luna Diabetes
Hyperlipidemia, Hyperglycemia
Evaluation of Health Effects of Adlay on Hyperlipidemia and Hyperglycemia Control
This study explores the efficacy of domestic adlay in improving blood sugar and lipids metabolism, cardiovascular function, and weight control in people with high blood pressure, hyperlipidemia, and hyperglycemia.
- Conditions
- Hyperlipidemia, Hyperglycemia, Type 2 Diabetes
- Trial name
- ADL (NCT05990595)
- Testing
- Adlay with white rice, white rice
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Obesity, Hypercholesterolemia
Improving the Management of Obesity in Primary Care Practice (The Power-UP Trial)
The purpose of the study is to compare three methods of achieving weight loss in primary care medical practice. The study will be conducted in six primary care practices.
- Conditions
- Obesity, Hypercholesterolemia, Metabolic Syndrome, Hypertension
- Trial name
- Power-UP (NCT00826774)
- Testing
- Usual Care, Brief Lifestyle Counseling, Enhanced Brief Lifestyle Counseling
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 1 Diabetes
The Role of Amylin and Glucagon in T1DM
The purpose of this study is to see if giving pramlintide and insulin before a meal would lower high blood sugar and if a glucagon (a naturally made hormone in the body but reduced in diabetes and its role is in prevention of low…
- Trial name
- NCT00206258
- Testing
- Pramlintide and glucagon
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Postprandial Hyperglycemia
Metabolic Effects of High-amylose Wheat-based Breads
The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial…
- Trial name
- NCT03899974
- Testing
- Test meal
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Obesity, Uric Acid Stones
Phentermine/Topiramate for Uric Acid Stones
The investigator proposes an 18 month, feasibility pilot study, randomizing obese and diabetic individuals with pure uric acid nephrolithiasis (UAN) or mixed calcium oxalate (CO) UAN to either phentermine/topiramate or a…
- Conditions
- Obesity, Uric Acid Stones, Type 2 Diabetes Mellitus in Obese, Pre-Diabetes
- Trial name
- NCT04621929
- Testing
- Phentermine / Topiramate Oral Product, Citrate Salts, Allopurinol, Diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Type 1 Diabetes
Closed Loop Context Aware AID
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a high blood sugar detection and dosing algorithm for use within an AP control system.
- Trial name
- NCT06676657
- Testing
- iPancreas automated insulin delivery system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Pre Diabetes
Assessment of the Impact of a Personalised Nutrition Intervention in Impaired Glucose Regulation
This study will determine if DNA-based dietary guidelines can improve glucose regulation in pre-diabetic individuals significantly more than standard dietary guidelines following 6 weeks of the intervention.
- Trial name
- ASPIRE-DNA (NCT03702465)
- Testing
- DNA-based dietary intervention, DNA-based dietary intervention using an app, Control arm
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Impaired Glucose Tolerance, Diabetes
A Lifestyle and Combination Medication Therapy Diabetes Prevention Study
It is now well established that the 21st century will be characterized by a global epidemic of Type 2 diabetes. The principal aim of the CANOE study is to determine whether individuals with the pre-diabetes condition impaired…
- Trial name
- NCT00116922
- Testing
- Avandamet [Rosiglitazone 2mg/Metformin 500mg] BID
- Where
- 2 sites in Canada
- Volunteers
- 207 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Glucose Metabolism Disorders, Perioperative Care
Accuracy and Safety of Real Time Continuous Glucose Monitoring Before, During and After Surgery
The purpose of this study is to determine the safety and accuracy of the Real-Time Continuous Glucose monitoring System (RT-CGMS)in measuring glucose in patients scheduled for surgery; before, during and after surgery.
- Trial name
- GluContinu (NCT00464529)
- Testing
- Real-Time Continuous Glucose monitoring System (RT-CGMS)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Research Foundation, The Netherlands
Postprandial Hyperglycemia
Investigation of Milk Peptides on Postprandial Blood Glucose Profile
Aim of the study is to investigate the effect of two different dosages of milk peptides on postprandial blood glucose profile in prediabetic subjects compared to placebo.
- Trial name
- NCT03932695
- Testing
- Low dose milk peptide, High Dose milk peptide
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ingredia S.A.
Type 2 Diabetes Mellitus, Colonoscopy
Abnormal Blood Sugar Tests in Diabetic Patients During Colonoscopy Preparation
Type 2 diabetes is rapidly increasing globally and has been associated with an increased risk of colorectal cancer. Therefore, the numbers of diabetic patients who will undergo colonoscopic screening are expected to grow…
- Trial name
- NCT03109951
- Testing
- Colonoscopy preparation using polyethylene glycol
- Where
- South Korea
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Catholic Kwandong University
Diabetes, Gestational, Pregnancy in Diabetics
Westlake Precision Birth Cohort
The Westlake Precision Birth Cohort (WeBirth) is a prospective cohort study among women with hyperglycemia during pregnancy and their offspring living in Hangzhou, China.
- Conditions
- Diabetes, Gestational, Pregnancy in Diabetics, Intrauterine Hyperglycemia
- Trial name
- WeBirth (NCT04060056)
- Testing
- Standardized breakfast, Standardized snack, Standardized lunch
- Where
- China
- Volunteers
- 2,001 people
- Sponsor
- Westlake University
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
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