Clinical trials: Elevated Blood Sugar
Acute Stroke, Acute Cerebral Ischemia
Efficacy and Safety of Continuous Intravenous Versus Usual Subcutaneous Insulin in Acute Ischemic Stroke
Hyperglycaemia is a frequent finding in acute ischemic stroke and associated with poor outcome. But the modalities of glucose lowering are still debated.
- Trial name
- INSULINFARCT (NCT00472381)
- Testing
- Insulin
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperglycemia, Aortic Valve Replacement
The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose
The overall research plan is to test the hypothesis that intraoperative treatment of hyperinsulinemic normoglycemic clamp (HNC) in cardiac surgical patients improves myocardial function and short-term outcomes compared with…
- Conditions
- Hyperglycemia, Aortic Valve Replacement, Aortic Stenosis, Cardiac Surgery
- Trial name
- NCT01187329
- Testing
- hyperinsulinemic normoglycemic clamp (HNC), control group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cleveland Clinic
Type1 Diabetes Mellitus
Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes
The goal of this longitudinal clinical trial is to measure variability of interstitial glucose levels with a user-friendly real-time continuous glucose monitoring (CGM) technology at regular intervals in normo- and dysglycemic…
- Trial name
- NCT05777330
- Testing
- Oral glucose tolerance test (OGTT), Hyperglycemic clamp test, Continuous glucose monitoring
- Where
- 6 sites in Belgium
- Volunteers
- 75 people
- Sponsor
- Universitair Ziekenhuis Brussel
Pancreatectomy; Hyperglycemia
Separate and Combined Extrapancreatic Effects of the Incretin Hormones
The two gut-derived hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) is secreted from intestinal cells in relation to a meal and increase insulin secretion from the pancreas.
- Trial name
- GA-19 (NCT05177653)
- Testing
- Intravenous infusion
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L)
Short-term Effect of Pomegranate Juice on Blood Sugar and Its Controlling Hormones in Pre-diabetic and Type II Diabetic Patients.
Fresh pomegranate juice at 1.5 mL/kg of body weight was administered by recruited healthy individuals and patients with type 2 diabetes of fasting serum glucose between 7.1 and 15.8 mmol/L after approximately 12 hours fasting.
- Trial name
- NCT03902288
- Testing
- Fresh pomegranate juice
- Where
- Jordan
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Type 2 Diabetes Mellitus
Impact of Bedtime Snacks on Glucose Control in Type 2 Diabetes
Approximately 3 million Canadians have type 2 diabetes, a condition where the blood sugar levels are too high, uncontrolled blood sugars lead to cardiovascular disease and other complications.
- Trial name
- NCT03207269
- Testing
- Dietary
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Healthy, Obesity & Overweight
Growth Hormone Resistance of Beta-cells
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired…
- Conditions
- Healthy, Obesity & Overweight, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
- Trial name
- GHRB-C (NCT07581860)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hyperglycemia
Efficacy and Safety of Hydrolysed Red Ginseng Extract on Improvement of Hyperglycemia
This study was conducted to investigate the effects of daily supplementation of hydrolysed red ginseng extract on improvement of Hyperglycemia.
- Trial name
- NCT03775733
- Testing
- Hydrolysed Red Ginseng Extract
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Type 2 Diabetes, Glucose Tolerance Impaired
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM
With REMD's glucagon receptor antagonist, the study team propose to provide a comprehensive examination of the effect of elevated plasma glucagon concentrations in Type 2 Diabetes Mellitus (T2D) patients on: (i) glucose…
- Conditions
- Type 2 Diabetes, Glucose Tolerance Impaired, Insulin Sensitivity
- Trial name
- NCT05093517
- Testing
- REMD-477
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Hyperglycemia, Obesity Prevention
The Impact of Low Glycemic Index Nutritional Shake on Glucose Regulation in Overweight and Obese Adults
Low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies.
- Trial name
- SHAKE (NCT06856460)
- Testing
- powder shake with very low glycemic index, Ceral Breakfast
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Pre Diabetes, Impaired Glucose Tolerance
Effect of F. Prausnitzii on Glycemic Control
The microbiota is associated with a wide spectrum of diseases including diabetes and non-alcoholic fatty liver disease. In this study we will investigate if the bacteria F.
- Conditions
- Pre Diabetes, Impaired Glucose Tolerance, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT04938843
- Testing
- F. prausnitzii and D. piger
- Where
- Sweden
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- MetaboGen AB
Acromegaly, Insulin Resistance
Co-treatment With Pegvisomant and a Somatostatin Analogue (SA) in SA-responsive Acromegalic Patients
The purpose of this study is to investigate if co-treatment of acromegalic patients, who beforehand are considered well-controlled on SA monotherapy, with pegvisomant and SA will improve insulin sensitivity and glucose tolerance…
- Conditions
- Acromegaly, Insulin Resistance, Impaired Glucose Tolerance
- Trial name
- NCT00652379
- Testing
- Pegvisomant, Somatostatin analog (lanreotide or octreotide)
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Impaired Glucose Tolerance, Pre-diabetes
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of…
- Conditions
- Impaired Glucose Tolerance, Pre-diabetes, Childhood Obesity, Insulin Resistance
- Trial name
- NCT00536250
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Yale University
Colorectal Cancer, Diabetes Mellitus
Glucose Homeostasis and Shared Genetic Factors in Colorectal Cancer
Colorectal cancer (CRC) and diabetes mellitus are two common diseases that frequently occur together and may share underlying genetic, metabolic, and immune-related mechanisms.
- Conditions
- Colorectal Cancer, Diabetes Mellitus, Glucose Homeostasis
- Trial name
- BRIDGE-CRCDM (NCT07648589)
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Psoriatic Arthritis, Psoriasis
Psoriatic Arthritis Treated With Liraglutide Therapy: a QUality of Life and Efficacy Study
Exploratory, double-blind randomized, placebo-controlled, Phase II study to evaluate the effect(s) of short-term administration of liraglutide, a GLP-1R (glucagon-like peptide-1 receptor) agonist on joint and skin inflammation in…
- Conditions
- Psoriatic Arthritis, Psoriasis, Impaired Glucose Tolerance, Type 2 Diabetes
- Trial name
- PLAQUE (NCT02472717)
- Testing
- liraglutide
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Hyperglycemia, Diabetes
Basal Bolus Versus Human Insulin in Hospitalized Patients With Diabetes in Paraguay
Few randomized studies have focused on the optimal management of non-ICU patients with type 2 diabetes in Latin America. Objective: Compare safety and efficacy of a basal bolus regimen with analogs and human insulins in general…
- Trial name
- NCT02278913
- Testing
- Basal Bolus (Glargine and Glulisine), Human Insulin
- Where
- Paraguay
- Volunteers
- 134 people
- Sponsor
- Universidad Nacional de Asunción
Metabolic Syndrome, Hypertension
Complications in Hypertension and Obesity
The study in aimed to investigate epidemiology of risk factors in Russian Federation its prognostic value aimed on acceptance of national specific definition of metabolic syndrome and guidelines for its management.
- Conditions
- Metabolic Syndrome, Hypertension, Obesity, Dyslipidemia
- Trial name
- NCT00552292
- Where
- Russia
- Volunteers
- 30,000 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Stress Hyperglycemia
Correlation of Hospital Stay Length With the Glucose Levels After Cardiac Surgery
The study is designed to test if there is any correlation between the glucose levels in the postoperatory period and the length of hospital stay.
- Trial name
- NCT02946411
- Testing
- Cardiac surgery
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Glucose Intolerance, Gastric Bypass Surgery
Examination of the Metabolic Effects of Direct Bile Salt Delivery to the Ileum in Humans
This project will evaluate distal intestinal bile salt administration in humans by deliving ursodeoxycholic acid (UDCA) into the terminal ileum of subjects with a pre-existing ileostomy and assessing several hormone levels…
- Trial name
- NCT03201952
- Testing
- Ursodeoxycholic Acid
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Stress Hyperglycemia, Diabetes Mellitus
Diabetes Mellitus After Intensive Care Admission
Stress hyperglycaemia is commonly observed during hospitalization in the intensive care unit (ICU) and has been shown to adversely influence outcome.
- Trial name
- DIAFIC (NCT02180555)
- Testing
- Oral glucose tolerance test
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Christophe De Block
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