Clinical trials: Elevated Intraocular Pressure
Glaucoma, Open-Angle
Visual Field Defect Estimation Using Sequentially Optimized Reconstruction Strategy on Healthy and Glaucoma Subjects
Perimetry is a well-established method that is used to measure the visual field functions of humans. Commercially available products, such as the OCTOPUS 900 (Haag-Streit AG, Koeniz, Switzerland), are commonly used for assessing…
- Trial name
- NCT03325751
- Testing
- Visual field testing
- Where
- Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glaucoma, Open-Angle, Normal Tension Glaucoma
Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects.
- Conditions
- Glaucoma, Open-Angle, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT03870230
- Testing
- Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Dynamic Vessel Analyzer (DVA), Pattern Electroretinography (pERG)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
Functional and Structural Imaging for Glaucoma
The specific aims of the clinical studies are to: Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion.
- Trial name
- FSOCT (NCT01957267)
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glaucoma
Real-time Glaucoma Medication Adherence
This study will evaluate the effectiveness of real-time data collected on patients taking topical medication to treat glaucoma. Patients will be randomized to two groups, the first of which will only use the study device to take…
- Trial name
- NCT03194828
- Testing
- Medication reminder, Medication monitoring only
- Where
- 8 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Subjects With Primary Open-angle Glaucoma (POAG)
Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering effect of two iStent devices in eyes of subjects with primary open-angle glaucoma
- Trial name
- NCT01252862
- Testing
- iStent
- Where
- Armenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Diagnositic Efficacy of Deep Convolutional Neural Network in Differentiation of Glaucoma Visual Field From Non-glaucoma Visual Field
Diagnostic Efficacy of CNN in Differentiation of Visual Field
Glaucoma is currently the leading cause of irreversible blindness in the world. The multi-center study is designed to evaluate the efficacy of the convolutional neural network based algorithm in differentiation of glaucomatous…
- Trial name
- NCT03759483
- Testing
- AI diagnostic algorithm
- Where
- China
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Myopia, Maculopathy
Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia.
The prevalence of myopia in East Asia and Singapore in particular is amongst the highest in the world, with estimates ranging from 30-70% of the general population. Up to 30% of these are high myopes.
- Conditions
- Myopia, Maculopathy, Glaucoma
- Trial name
- NCT00347451
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Glaucoma
Blood Flow Regulation in Glaucoma
Glaucoma is one of the leading causes for blindness in industrialized countries. It is characterized by a progressive loss of retinal ganglion cells, morphological changes in the optic nerve head and a characteristic loss of…
- Trial name
- NCT02292381
- Testing
- Isometric exercise
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
Ahmed Glaucoma Valve Implantation; Graft-Free Short Tunnel Small Flap Versus Scleral Patch Graft
Glaucoma implants have been used for refractory glaucoma and are gaining popularity as a primary procedure in selected patients.
- Trial name
- NCT03551834
- Testing
- Conventional scleral patch graft glaucoma implantation, New surgical method (short tunnel small flap technique)
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma
Comparing Conscious Sedation to Retrobulbar Block Anesthetics During Trans-scleral Diode Laser
This is a non-inferiority trial with a prospective randomized controlled design assessing patient satisfaction and complications associated with both retrobulbar block anesthetics (current gold standard) and conscious IV sedation…
- Trial name
- NCT03646500
- Testing
- Retrobulbar Block, Remifentanil
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Queen's University
Glaucoma
Intraocular Pressure (IOP) Lowering Efficacy of Transdermal Brimonidine Therapy
The purpose of this study is to evaluate the safety and effectiveness in lowering intraocular pressure (IOP) utilizing an experimental lotion containing 0.1% Brimonidine that is applied to the outside of one eyelid.
- Trial name
- NCT01345448
- Testing
- Brimonidine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Nanduri, Padma, M.D., FACS
Obstructive Sleep Apnoea, Open Angle Glaucoma
Prevalence of Obstructive Sleep Apnoea in Glaucoma
This study aims to investigate a potential link between Obstructive Sleep Apnoea (OSA) and Open Angle Glaucoma (OAG); initially by determining whether the prevalence of OSA is higher in patients with OAG in comparison to people…
- Trial name
- POSAG (NCT02713152)
- Where
- United Kingdom
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Glaucoma, Open-Angle
Trabeculectomy Versus 2-iStent and Prostaglandin Study
Investigators hypothesize that the synergistic action of iStent in increasing aqueous outflow through the trabecular meshwork and use of prostaglandin analog such as travoprost or latanoprost to increase uveoscleral outflow will…
- Trial name
- TIPS (NCT03274323)
- Testing
- iStent and travoprost or latanoprost, Trabeculectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Retinal Disease, Healthy
Data Gathering for A10900
The objective of this study is to gather Optical Coherence Tomography (OCT) data on normal and diseased eyes
- Conditions
- Retinal Disease, Healthy, Glaucoma, Corneal Diseases
- Trial name
- NCT07149740
- Testing
- OCT
- Where
- 4 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Glaucoma, Glaucoma, Primary Open Angle
UCP (Ultrasound Cyclo Plasty) in the Treatment of Chinese Patients With Primary Open-angle Glaucoma
Traditional ciliary body photocoagulation treatment uses the photocoagulation of long-wavelength laser to destroy the ciliary body tissue that can produce aqueous humor.
- Trial name
- NCT04321122
- Testing
- ultrasound cyclo plasty
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Ocular Hypertension
Effect of Alternate Therapies on Intraocular Pressure in Ocular Hypertension
The purpose of this study is to evaluate the effect of complementary and alternative therapies, specifically alternate nostril breathing and foot reflexology, on intraocular pressure in patients with ocular hypertension.
- Trial name
- NCT02993445
- Testing
- Alternate Nostril Breathing, Foot Reflexology
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Temple University
Primary Open-angle Glaucoma
Effects of Primary Open-angle Glaucoma on Visual-motor Coordination
Commonly used visual function assessments in glaucoma diagnosis and treatment-such as visual acuity, visual field, and contrast sensitivity-do not directly capture the impact of the disease on patients' daily abilities.
- Trial name
- NCT06692205
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma
Retinal Nerve Fiber Layer Thickness Measurement on Parapapillary Atrophy With the Cirrus High-Definition (HD) Optical Coherence Tomography (OCT)
Retinal nerve fiber layer (RNFL) thickness measurement on the parapapillary atrophy is incorrect. Because a new spectral domain OCT, the Cirrus HD OCT, uses a movable circle to analyze the RNFL thickness, we may suggest a new…
- Trial name
- NCT00742196
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Open Angle Glaucoma, Ocular Hypertension
A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension
This is a Phase I/II stage to investigate the safety, tolerability, and ocular hypotensive efficacy of TO-O-1001 in healthy volunteers and patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT05456724
- Testing
- TO-O-1001
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Theratocular Biotek Co.
Glaucoma, Glaucoma; Drugs
Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops
According to the American Academy of Ophthalmology's Preferred Practice Pattern on Primary Open Angle Glaucoma, patients should wait five minutes between administering topical drops for intra-ocular pressure reduction.
- Trial name
- NCT03220490
- Testing
- 5 minute interval between regular glaucoma drops - Long term, no interval between regular glaucoma drops - Long term, IOP reduction of Brimonidine and Timolol with time interval
- Where
- Israel
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center