Clinical trials: Elevated Intraocular Pressure
Glaucoma
Lipid Profile of Tenon's Capsule
The purpose of this study is to provide data on the lipid profile of the Tenon's capsule in Human glaucomatous eyes and to establish possible relationships with the short term outcome of filtration surgery.
- Trial name
- NCT01021657
- Testing
- trabeculectomies, non penetrating deep sclerectomies
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Glaucoma
Screening and Intervention for Glaucoma and Eye Health Through Telemedicine
This is a multiple site, randomized study that will assess the effects of personalized eHealth education and motivational-interviewing-based counseling on patient adherence to physician follow-up appointments.
- Trial name
- SIGHT (NCT04274764)
- Testing
- Personalized eHealth Education & Motivational Interviewing
- Where
- 2 sites in United States
- Volunteers
- 622 people
- Sponsor
- University of Michigan
Open-angle Glaucoma
Efficacy and Safety of XEN® Gel Stent and Post-operative Management in Patients With Open Angle Glaucoma
To evaluate the efficacy of postoperative management with 5-fluorouracil injections after XEN Gel Stent implantation.
- Trial name
- NCT03904381
- Testing
- 5-fluorouracil, Transconjunctival needling, Transconjunctival revision
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Wroclaw Medical University
Glaucoma, Ocular Hypertension
Study to Evaluate Safety of Brimonidine/Timolol Fixed Combination in Glaucoma or Ocular Hypertension Patients
This study evaluates the safety of brimonidine/timolol fixed combination in glaucoma or ocular hypertension patients
- Trial name
- NCT00651612
- Testing
- Brimonidine 0.2%/Timolol 0.5% Fixed Combination Ophthalmic Solution, Concurrent brimonidine 0.2% and 0.5% timolol
- Where
- United States
- Volunteers
- 604 people
- Sponsor
- Allergan
Glaucoma
Real-time Glaucoma Medication Adherence
This study will evaluate the effectiveness of real-time data collected on patients taking topical medication to treat glaucoma. Patients will be randomized to two groups, the first of which will only use the study device to take…
- Trial name
- NCT03194828
- Testing
- Medication reminder, Medication monitoring only
- Where
- 8 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Normal Tension Glaucoma
Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in NTG
The purpose of this study is to evaluate the effect of Ginkgo biloba extract (GBE) on the number of blood vessels in the back of the eye as well as the amount of blood flow at the nailfold(where the fingernail meets the skin) of…
- Trial name
- NCT03761992
- Testing
- Gingko Baloba
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Robert Ritch, MD, LLC.
Open Angle Glaucoma
Automatic vs. Manual Optic Disc Planimetry
Manually and automatically by mashing learning algorithm optic disc will be evaluated (planimetry).
- Trial name
- Planimetry (NCT02438319)
- Testing
- manual planimetry, automated planimetry
- Sponsor
- University of Zurich
Glaucoma
Metformin as a Neuroprotective Therapy for Glaucoma
Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve…
- Trial name
- NCT05426044
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Christopher Kai Shun Leung
Glaucoma, Open-Angle, Ocular Hypertension
A Phase 2 Study Of The 24-Hour Intraocular Pressure Lowering And Systemic Exposure Of PF-04217329
This study will characterize the effect of PF-04217329, alone and in combination with latanoprost, on circadian intraocular pressure and blood pressure in glaucoma patients.
- Trial name
- NCT00934089
- Testing
- PF-04217329, latanoprost vehicle, latanoprost
- Where
- 8 sites in United States
- Volunteers
- 31 people
- Sponsor
- Pfizer
Primary Open Angle Glaucoma (POAG)
A Real-World Evidence Study of Goniotomy With the C-REX™ Instrument in Patients With Primary Open Angle Glaucoma
This study enrolls adults with primary open angle glaucoma (POAG) who underwent goniotomy intraocular pressure (IOP)-lowering surgery with the C-Rex Instrument.
- Trial name
- CIRCLE (NCT06615661)
- Testing
- C-Rex Instrument
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Iantrek, Inc.
Open Angle Glaucoma, Ocular Hypertension
Efficacy and Safety of the ExPRESS Implant Versus Deep Sclerectomy in Combined Surgery
The Ex-PRESS Glaucoma Filtration Device is a small, non-valved implant that was designed to lower intraocular pressure (IOP) by shunting aqueous humor from the anterior chamber into the subconjunctival space.
- Trial name
- NCT03201354
- Testing
- Filtration surgery with Ex-PRESS, Non penetrating deep sclerectomy, Cataract extraction
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Institut Catala de Retina
Glaucoma, Open-Angle
Micropulsed Laser Trabeculoplasty Using Different Parameters
This randomized, double blinded, clinical trial compares two different parameters setting of micropulsed laser trabeculoplasty for open angle glaucoma. Group one is treated with 1500 mW of Power, Group two with 1000 mW.
- Trial name
- NCT04900142
- Testing
- Micropulsed laser trabeculoplasty
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Modena and Reggio Emilia
Primary Open Angle Glaucoma, Pseudoexfoliative Glaucoma
Comparing Effectiveness of the Hydrus Microstent (TM) to Two iStents to Lower IOP in Phakic Eyes
This clinical trial compares two implantable devices intended to lower the pressure inside the eye of glaucoma patients.
- Conditions
- Primary Open Angle Glaucoma, Pseudoexfoliative Glaucoma, Pigmentary Glaucoma
- Trial name
- COMPARE (NCT02023242)
- Testing
- Hydrus Microstent, iStent Trabecular Micro Bypass
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Ivantis, Inc.
Glaucoma
Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin C
A clinical trial to establish the long term response of using intraoperative 5-fluorouracil (5-FU) versus mitomycin C (MMC) in trabeculectomy glaucoma surgery.
- Trial name
- NCT00346489
- Testing
- 5-fluorouracil, Mitomycin C
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Indiana University
Subjects With Primary Open-angle Glaucoma (POAG)
Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering effect of two iStent devices in eyes of subjects with primary open-angle glaucoma
- Trial name
- NCT01252862
- Testing
- iStent
- Where
- Armenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Diagnositic Efficacy of Deep Convolutional Neural Network in Differentiation of Glaucoma Visual Field From Non-glaucoma Visual Field
Diagnostic Efficacy of CNN in Differentiation of Visual Field
Glaucoma is currently the leading cause of irreversible blindness in the world. The multi-center study is designed to evaluate the efficacy of the convolutional neural network based algorithm in differentiation of glaucomatous…
- Trial name
- NCT03759483
- Testing
- AI diagnostic algorithm
- Where
- China
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Obstructive Sleep Apnea, Hypopnea Syndrome
Retinal Nerve Fiber Layer Thickness Measurements in Patients With Sleep Apnea Syndrome
The purpose of this study was to measure the retinal nerve fiber layer (RNFL) thickness in eyes of Obstructive Sleep Apnea/hypopnea syndrome (OSAHS) using optical coherence tomography (OCT), and assess whether it is decreased.
- Conditions
- Obstructive Sleep Apnea, Hypopnea Syndrome, Glaucoma
- Trial name
- NCT01188291
- Where
- Israel
- Volunteers
- 166 people
- Sponsor
- Carmel Medical Center
Open Angle Glaucoma
MIMS® Retrospective Chart Review
This is a post-market clinical follow-up, retrospective chart review of MIMS® surgical procedures conducted during time period between Sep 2023 and April 2025.
- Trial name
- NCT06614218
- Testing
- Minimally Invasive Micro Sclerostomy
- Where
- Armenia
- Volunteers
- 34 people
- Sponsor
- Sanoculis Ltd
Open-Angle Glaucoma, Ocular Hypertension
A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension
This study will evaluate the 24-hour intraocular pressure lowering effect and safety after a single administration of Bimatoprost SR in patients with Open-Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT04285580
- Testing
- Bimatoprost SR, LUMIGAN
- Where
- 6 sites in United States
- Volunteers
- 37 people
- Sponsor
- AbbVie
Glaucoma
Bioequivalence Study With Clinical Endpoint Comparing Brinzolamide 1% Ophthalmic Suspension to Azopt® 1% Ophthalmic Suspension In the Treatment of Chronic Open Angle Glaucoma or Ocular Hypertension in Both Eyes
This is a randomized, double blind, two-arm, parallel group, active controlled bioequivalence study, at multiple clinical trial sites designed to demonstrate bioequivalence of Brinzolamide 1% ophthalmic suspension (manufactured…
- Trial name
- NCT02512042
- Testing
- Test-Brinzolamide 1% Ophthalmic suspension, Reference-Brinzolamide 1% Ophthalmic suspension
- Where
- 10 sites in United States
- Volunteers
- 973 people
- Sponsor
- Actavis Inc.