Clinical trials: Elevated Liver Enzymes
Metabolic Health, Elevated Liver Enzymes
A Clinical Trial to Evaluate the Effects of a Plant-Based Liquid Supplement on Metabolic Health and Overall Well-Being
This single-arm clinical trial will evaluate the effects of a plant-based liquid supplement on metabolic health, digestive health, skin health, and overall well-being.
- Conditions
- Metabolic Health, Elevated Liver Enzymes, Digestive Symptoms
- Trial name
- NCT07673432
- Testing
- Plant-Based Liquid Supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Biocol Labs
Liver Fibrosis, Steatohepatitis
Liver Fibrosis in HIV-Infected Patients With Elevated Liver Enzymes on Antiretroviral Therapy
This study will provide a basis for research on the impact of liver injury caused by antiretroviral therapy in HIV-infected patients.
- Conditions
- Liver Fibrosis, Steatohepatitis, Elevated Transaminases
- Trial name
- NCT00326482
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Visceral Fat, Liver Dysfunction
Weight Loss Effect on Circulating Liver Enzymes
To investigate weight loss effect with mild calorie restriction on circulating levels of liver enzymes in nondiabetic and overweight subjects with high visceral fat area [visceral fat area (VFA) at L4 ≥ 100 cm²].
- Trial name
- NCT02992639
- Testing
- Control group, Weight loss group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Burns
Calisthenics Exercise and Electromagnetic Therapy on Liver Function Following Burn Injuries.
Serum concentrations of alanine transaminase (ALT) and aspartate transaminase (AST) significantly increased immediately upon burn trauma and remained significantly elevated for about three years.
- Trial name
- NCT06138886
- Testing
- Pulsed electromagnetic therapy, calisthenics exercises
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Non-alcoholic Fatty Liver Disease
A Study to Compare MitoQ and Placebo to Treat Non-alcoholic Fatty Liver Disease (NAFLD)
The purpose of this study is to investigate whether a new medicine, called mitoquinone, will reduce raised liver enzymes due to NAFLD and to see if it is safe.
- Trial name
- MARVEL (NCT01167088)
- Testing
- Mitoquinone mesylate
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Antipodean Pharmaceuticals, Inc.
Hepatopathy
The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment
Introduction. Statins are generally well tolerated but not devoid of side effects. Quite often it is manifested by asymptomatic increase in the level of aspartate and alanine aminotransferase.
- Trial name
- NCT03121521
- Testing
- Melatonin 10 mg
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Alcohol-Related Liver Disease, Drug-Induced Liver Injury
Misocholic Tablets for Non-Viral Elevated Liver Enzymes
Elevated liver enzymes are common laboratory abnormalities that may result from alcohol-related liver disease, drug-induced liver injury, or non-alcoholic fatty liver disease (NAFLD).
- Conditions
- Alcohol-Related Liver Disease, Drug-Induced Liver Injury, Non-alcoholic Fatty Liver Disease
- Trial name
- NCT07833514
- Testing
- Misocholic Tab, Silymarin (Silybum marianum)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Hanoi Medical University
Liver Function Failure
TONKA Versus Legalon for Lowering Hepatic Enzymes in Liver Function Disorder Patients.
The purpose of this study is to evaluate the efficacy TONKA on the reduction of ALT and AST in moderate to severe liver enzyme elevated patients; compared with Silymarin (Legalon) after 6 weeks of treatment.
- Trial name
- NCT03216668
- Testing
- TONKA, LEGALON
- Where
- Vietnam
- Volunteers
- 140 people
- Sponsor
- Nhat Nhat Pharmaceutical Company
Preeclampsia
Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders
The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.
- Trial name
- NCT06333652
- Testing
- Ravulizumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Liver Functions Tests
Desflurane and Sevoflurane in Pediatrics With Elevated Liver Enzymes
It is designed to compare effects of inhaled anaesthetic desflurane and sevoflurane on liver functions in pediatric cancer patients
- Trial name
- NCT04775212
- Testing
- Desflurane, Sevoflurane
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Pregnancy, HELLP Syndrome
Pancreatic Stone Protein (PSP) in Pregnant Women
This prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during…
- Conditions
- Pregnancy, HELLP Syndrome, Preterm Premature Rupture of Fetal Membranes, Preeclampsia
- Trial name
- NCT02247297
- Testing
- Blood collection
- Where
- Switzerland
- Volunteers
- 486 people
- Sponsor
- Nicole Ochsenbein
Covid19, Liver Diseases
Silymarin in COVID-19 Patients Admitted to Hospital With Elevated Liver Enzymes
Of patients admitted to an internal medicine ward with internistic diagnosis/es together with COVID-19, substantial proportion has elevated liver enzymes.
- Trial name
- SILCOVINT-21 (NCT04816682)
- Testing
- Silymarin
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
COVID-19 Pandemic
Elevated Liver Enzymes as a Predictor of Acute Kidney Injury in Hospitalized Patients With COVID-19
In critically ill patients, AKI is a common complication of COVID-19 infection, occurring in 23% to 43% of cases, and was correlated with poor clinical outcomes.
- Trial name
- COVID-19 (NCT05157152)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Liver Enzymes After General or Spinal Anesthetic Techniques, In Patients With Preoperatively Elevated Liver Enzymes
Comparative Study of the Change in Liver Enzymes After General or Spinal Anesthetic Techniques in Patients With Preoperatively Elevated Liver Enzymes.
To assess the changes in liver functions postoperatively in patients with preoperatively elevated liver enzymes. To identify the most appropriate anesthesia technique for patients with preoperatively elevated liver enzymes.
- Trial name
- NCT03421990
- Testing
- General anesthesia
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Burns
Response of Liver to 12 Weeks of Resistance Band Training Program in Burned Patients.
Serum concentrations of alanine transaminase (ALT) and aspartate transaminase (AST) significantly increased immediately upon burn trauma and remained significantly elevated for about three years.
- Trial name
- NCT06067711
- Testing
- resistance band
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Elevated Liver Enzymes
Screening for Liver Fibrosis by Using Non-invasive Methods ( Fibro Scan) in Patients With Elevated Liver Enzymes
BACKGROUND: Fibrosis assessment by Transient Elastography or Fibro scan is validated in chronic hepatitis C, however limited data are available in chronic hepatitis B and in non alcoholic fatty liver disease (NAFLD).
- Trial name
- NCT01784484
- Testing
- No intervention
- Where
- Israel
- Sponsor
- Assy Nimer
Cardiac Surgery Associated - Acute Kidney Injury, Acute Kidney Injury
Association Between Liver Function Tests and Acute Kidney Injury in Cardiac Surgery Patients
A sudden decline in function of the kidneys is a common problem that can happen after heart surgery. It can have serious effects on a patient's recovery and long-term health, potentially leading to permanent kidney problems or…
- Trial name
- TransAKI (NCT06730854)
- Where
- Belgium
- Volunteers
- 3,415 people
- Sponsor
- University Hospital, Ghent
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Drug-induced Liver Injury
Impact of Silymarin Dosages to Decrease Drug-induced Elevated Liver Enzymes Compared to Placebo
In this clinical study silymarin will be administered in different dosages and compared to placebo in order to address if the liver protecting features of silymarin, measured by changes of liver enzyme concentration, can be…
- Trial name
- SILVER (NCT05144217)
- Testing
- 2x 140 mg per day, 3x 280 mg per day, 1x 1120 mg
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- Prof. Dr. Frank Behrens
Non Alcoholic Fatty Liver Disease, Steatohepatitis
Genetic Effect on Omega 3 Fatty Acids for the Treatment of Fatty Liver Disease
To explore whether there is a different response to omega-3 fatty acid rich diet with respect to the hepatic fat fraction % (HFF), triglyceride, and ALT levels between the rs738409 minor allele (GG) and the common allele…
- Conditions
- Non Alcoholic Fatty Liver Disease, Steatohepatitis, Hypertriglyceridemia, Alanine Aminotransferase, Plasma Level of, Quantitative Trait Locus 1
- Trial name
- NCT01556113
- Testing
- Omega diet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University