Clinical trials: Elevated Risk of Cardiovascular Disease
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health
Ischemic Heart Disease, Post-Operative Complications
On-Pump vs. Off-Pump CABG in High-Risk Patients (EuroSCORE 6+)
Previous studies comparing on-pump and off-pump operating strategy did only partially demonstrate benefits of the off-pump myocardial revascularisation.In primary end-points (MI, death, renal failure, and so on) there was no…
- Trial name
- PRAGUE 6+ (NCT00606372)
- Testing
- OPCAB - the off-pump coronary artery bypass
- Where
- 2 sites in Czechia
- Volunteers
- 220 people
- Sponsor
- Charles University, Czech Republic
Coronary Artery Disease, Heart Disease
The WOMEN Study: What is the Optimal Method for Ischemia Evaluation in WomeN?
The purpose of this study is to compare two types of exercise stress testing to find the best method for detecting heart disease in women.
- Conditions
- Coronary Artery Disease, Heart Disease, Coronary Arteriosclerosis, Cardiovascular Disease
- Trial name
- NCT00282711
- Where
- 43 sites in United States, Canada
- Volunteers
- 824 people
- Sponsor
- Hartford Hospital
Atrial Fibrillation
Pleotropic Effect of New Oral Anticoagulants
Atrial fibrillation (AF) has been known to have several pathophysiologic mechanisms including endothelial dysfunction of heart and vessel.
- Trial name
- NCT02544932
- Testing
- dabigatran, ribaroxaban, Warfarin
- Where
- South Korea
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Stroke, Parkinson Disease
Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk
The purpose of this study is to evaluate the feasibility and efficacy of a smart airbag system that detects and mitigates fall-related impact in individuals with high fall risk.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury
- Trial name
- NCT05076565
- Testing
- Airbag Belt Fall Protection System
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Myocardial Infarction (MI), Acute Coronary Syndromes (ACS)
Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients Without ST-Segment Elevation
People who call emergency medical services (EMS) with chest pain or other possible heart-related symptoms are often taken to hospital for further testing.
- Trial name
- Pre-POCT TnI (NCT07563998)
- Testing
- Prehospital high-sensitivity cardiac troponin I measurement
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Central Denmark Region
Primary Angioplasty
Evaluation of Feasibility of Radial Access for Primary Angioplasty and to Assess it in High Risk Subgroups
Primary percutaneous coronary intervention is the preferred treatment for patients with ST-segment acute coronary syndrome. The radial access is an established approach, associated with a reduction in vascular access related…
- Trial name
- NCT03488407
- Volunteers
- 315 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Chronic Myeloproliferative Disorders, Leukemia
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
RATIONALE: Tests that measure certain changes in blood in patients at high risk of cytomegalovirus infection may help doctors learn more about predicting cytomegalovirus infection after donor stem cell transplant.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00716911
- Testing
- ganciclovir, polymerase chain reaction, flow cytometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Diabetes, Diabetes Mellitus, Type 2
A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events
This trial is conducted globally. The aim of this trial is to compare cardiovascular safety of insulin degludec versus insulin glargine in subjects with type 2 diabetes at high risk of cardiovascular events.
- Trial name
- DEVOTE (NCT01959529)
- Testing
- insulin degludec, insulin glargine
- Where
- 446 sites in United States, Algeria and 18 more
- Volunteers
- 7,637 people
- Sponsor
- Novo Nordisk A/S
Atherosclerotic Cardiovascular Disease, Atherosclerotic Cardiovascular Disease Risk Equivelents
Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced Support
The purpose of this study was to evaluate the implementation of inclisiran in a regional primary care setting in the UK Inclisiran, also known as KJX839, is a medication made to reduce the level of "bad" cholesterol…
- Conditions
- Atherosclerotic Cardiovascular Disease, Atherosclerotic Cardiovascular Disease Risk Equivelents, Elevated Low Density Lipoprotein Cholesterol
- Trial name
- SPIRIT (NCT04807400)
- Testing
- Inclisiran, Behavioural Support, Background lipid lowering therapy
- Where
- 17 sites in United Kingdom
- Volunteers
- 892 people
- Sponsor
- Novartis Pharmaceuticals
Postoperative Complications, Cardiovascular Complication
Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery
Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown.
- Conditions
- Postoperative Complications, Cardiovascular Complication, Myocardial Ischemia, Inflammation
- Trial name
- INSIGHT (NCT04753307)
- Testing
- Laboratory measurements
- Where
- Austria
- Volunteers
- 1,400 people
- Sponsor
- Medical University of Vienna
Atherosclerotic Cardiovascular Disease
Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE
Childhood cancer survivors are at increased risk for premature atherosclerotic cardiovascular disease (ASCVD) due to cancer treatment-related exposures, including radiation therapy and platinum-based chemotherapy.
- Trial name
- NCT07594392
- Testing
- Coronary Artery Calcium Scan, Carotid Artery Ultrasound, Lipoprotein(a) Measurement
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- St. Jude Children's Research Hospital
Metabolic Syndrome
Canola Oil Multicentre Intervention Trial
The purpose of the study is to examine how the consumption of different dietary oil varieties affects a broad range of metabolic responses that are important in the development of cardiovascular diseases.
- Trial name
- COMIT (NCT01351012)
- Testing
- Corn and safflower oil, Canola oil, High oleic acid canola oil
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of Manitoba
Plasma Cell Myeloma
Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma
This phase II trial studies the effect of belantamab mafodotin, pomalidomide, and dexamethasone in treating patents with high-risk myeloma.
- Trial name
- NCT05208307
- Testing
- Belantamab Mafodotin, Dexamethasone, Pomalidomide
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Coronary Artery Disease, Plaque
PCCT-Defined High-Risk Plaque and Future Coronary Events: The PREDICT Study
This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE).
- Conditions
- Coronary Artery Disease, Plaque, Photon-Counting Computed Tomography
- Trial name
- PREDICT (NCT07822737)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Chao Yang Hospital
Pulmonary Arterial Hypertension
Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13)
The objective of this study is to evaluate the effects of sotatercept (MK-7962, formerly called ACE-011) treatment (plus background pulmonary arterial hypertension [PAH] therapy) versus placebo (plus background PAH therapy) on…
- Trial name
- HYPERION (NCT04811092)
- Testing
- Sotatercept
- Where
- 152 sites in United States, Argentina and 25 more
- Volunteers
- 321 people
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Arrhythmogenic Cardiomyopathy (AC, ARVD/C)
Cardiac Rehabilitation in Patients With High-Genetic-Risk Arrhythmogenic Cardiomyopathy: The HGEN-CARE-AC Trial
The goal of this clinical trial is to evaluate a structured and personalized cardiac rehabilitation program for patients diagnosed with arrhythmogenic cardiomyopathy (ACM) who carry high-risk genetic mutations.
- Trial name
- HGEN-CARE-AC (NCT07708311)
- Testing
- Cardiac Rehabilitation Programme
- Volunteers
- 70 people
- Sponsor
- Juan Jiménez Jáimez
Venous Thromboembolism, Patient-Centered Care
Anticoagulation Medical Home
The primary study goal is to improve the quality of care transitions for patients with new episodes of venous thromboembolism (VTE).
- Trial name
- NCT02870296
- Testing
- Enhanced Assessment and Education
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Long-term Major Cardiovascular Events, Myocardial Infarction
CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction
The purpose of this registry is to evaluate long-term clinical events in patients with acute myocardial infarction who were treated with percutaneous coronary intervention.
- Conditions
- Long-term Major Cardiovascular Events, Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- COREA-AMI (NCT02385682)
- Testing
- Percutaneous coronary intervention
- Volunteers
- 4,748 people
- Sponsor
- Kiyuk Chang
Vascular Diseases, Peripheral Vascular Disease
Topical Gentamicin and Vancomycin for Vascular Surgical Site Infection Prophylaxis
Many patients who undergo vascular surgery to improve the blood flow to their legs are at risk of developing an infection in the surgical site and are then at risk of serious complications such as hospital readmission, failure of…
- Conditions
- Vascular Diseases, Peripheral Vascular Disease, Surgical Site Infection, Bypass Complication
- Trial name
- NCT04238923
- Testing
- Topical vancomycin paste (1g vancomycin powder + 4mL sterile saline) and Collatamp G gentamicin-eluting sponge (Azralez Pharmaceuticals; 2.0mg gentamicin sulphate/cm2 to cover wound)
- Volunteers
- 356 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.