Clinical trials: Elevated Triglycerides
Ketogenic Diet, Exercise
High Fat Meal and Postprandial TG Levels With and Without Exercise Intervention
The objective of this study is to investigate whether "real-life" bouts of MIE are effective at attenuating PPTL after a meal (either a keto-type brownie (KETO) or a high carb (CON) meal of pasta and sauce), compared to…
- Trial name
- NCT05291767
- Testing
- Diet, Exercise
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Intra-abdominal Fat, Metabolic Syndrome
Habitual Diet and Avocado Trial
The Habitual Diet and Avocado Trial will evaluate the effects of providing one avocado per day for recommended consumption over a 6 month period in a cohort of approximately 1000 free-living participants with increased waist…
- Conditions
- Intra-abdominal Fat, Metabolic Syndrome, High Cholesterol, Triglycerides High
- Trial name
- HAT (NCT03528031)
- Testing
- Intervention Daily Avocado
- Where
- 4 sites in United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Lipid Disorder, Triglycerides High
Vascepa to Accelerate Lipoprotein Uptake and Elimination
This study is a Phase 1 pilot/feasibility mechanistic experiment to help clarify the mechanism of action of an EPA-rich fish oil preparation, icosapent ethyl, on lipid changes in statin-treated patients with residual…
- Conditions
- Lipid Disorder, Triglycerides High, Dyslipidemias
- Trial name
- VALUE (NCT03885661)
- Testing
- Icosapent Ethyl 1000 MG [Vascepa]
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Pharmacokinetics and Pharmacodynamics of Fructose
The purpose of this study is to determine whether sucrose vs high fructose corn syrup from a soft drink results in differences in various metabolic byproducts such as fructose, glucose, serum uric acid, triglyceride and lactate.
- Trial name
- NCT00661947
- Testing
- Dr Pepper sweetened with sucrose or high fructose corn syrup
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hypertriglyceridemia
Effect of Fish Oil on Plasma Triglycerides in Adults
The purpose of this small, short pilot study is to determine the feasibility (e.g., recruitment, dose acceptance, retention) of a future longer trial comparing the effects of two types of omega-3 fats from fish oil on plasma…
- Trial name
- NCT00804427
- Testing
- Fish oil (90% triglycerides), Fish oil (60% triglycerides), Fish oil (ethyl esters)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Overweight, Hypertriglyceridemic Waist
Characterization of the Metabolic Fate of an Oral Arginine Form
The purpose of this study is to compare the metabolic fate of two oral forms of L-Arginine in healthy subjects featuring metabolic syndrome related risk factors
- Trial name
- NCT02352740
- Testing
- A form Arginine, B form Arginine
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Dyslipidemias, Familial Hypercholesterolemia
A VSA003 Phase 1 Study in Chinese Adult Healthy Volunteers
This is a randomized, double blinded, phase 1 study. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single dose of VSA003 in healthy adult volunteerst
- Conditions
- Dyslipidemias, Familial Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT05851066
- Testing
- VSA003, 0.9% NaCl
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Visirna Therapeutics HK Limited
Hypertriglyceridemia
Effect of Candida Rugosa Lipase on Serum Triglyceride Lowering
The primary objective of this study was to evaluate the safety and tolerability of 3 doses of fungal lipase in the treatment of adults with mildly elevated serum triglycerides.
- Trial name
- NCT05295134
- Testing
- Candida cylindracea lipase (225,000 FIP lipase units per day), Candida cylindracea lipase (450,000 FIP lipase units per day), Candida cylindracea lipase (675,000 FIP lipase units per day)
- Where
- Ireland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- BIO-CAT, Inc.
Hypertriglyceridemia
Postprandial Lipid Metabolism in Patients With Hypertriglyceridemia and Normo-lipidemic Controls: Medium Chain Fatty Acids (MCT) in Comparison to Long-chain, Saturated Fatty Acids (SFA) and Mono-unsaturated Fatty Acids (MUFA)
Postprandial lipid metabolism will be evaluated in patients with hypertriglyceridemia and normo-lipidemic controls; different fats will be used (saturated fatty acids, mon-unsaturated fatty acids and medium chain fatty acids) for…
- Trial name
- NCT03846908
- Testing
- MCT, SFA, MUFA
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Inflammation, Metabolic Disorder
Impact of Aronia Berry Consumption on Inflammation, Metabolites, and the Gut Microbiome
The goal of this project is to elucidate interactions between the gut microbiome, anti-inflammatory/anti-oxidant food metabolomic signatures, and human inflammation phenotypes.
- Conditions
- Inflammation, Metabolic Disorder, Hypertriglyceridemia
- Trial name
- NCT05255718
- Testing
- Aronia juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montana State University
Cardiovascular Disease
An Open-label Single Dose Randomized, Parallel Group Study Followed by Single-blind Repeat Dosing, to Compare the Relative Bioavailability of GSK2212836.
Sixteen healthy subjects will be randomized to each of the 3 parallel treatment groups. Eligible subjects will check in to the clinical unit on Day -2 and have 24-hr pharmacokinetic collections on Day -1 and on Day 1.
- Trial name
- NCT00996268
- Testing
- GSK2212836
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dyslipidemias, Atherosclerosis
Dyslipidemia Prevalence, Perception, Treatment, and Awareness in the Tunisian Population
ATERA Survey is a national cross sectional observational study, aiming to determine the prevalence of dyslipidemia and other conventional risk factors for CHD (Coronary Heart Disease), the relationship between environmental and…
- Conditions
- Dyslipidemias, Atherosclerosis, Households, Survey, Family Life
- Trial name
- ATERASurvey (NCT03799185)
- Where
- Tunisia
- Volunteers
- 13,610 people, healthy volunteers welcome
- Sponsor
- Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose
Hypertriglyceridemia
Supplementation With Omega-3: Mechanism of Action
This is a trial of two marketed fish oil supplements, one with a high EPA:DHA ratio and the other with a high DHA:EPA ratio, to examine differential effects on platelet function, blood pressure, and fasting triglyceride levels.
- Trial name
- SOMA (NCT02036307)
- Testing
- DHA-enriched, EPA-enriched
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sedentary Lifestyle, Dyslipidemias
Effects of Exercise on Fructose-induced Postprandial Lipemia
Cardiovascular Diseases (CVDs) are the leading causes of death in the world and in Brazil. In 2001, 12.45 million deaths on the globe (21% of the total) were caused by some CVD.
- Conditions
- Sedentary Lifestyle, Dyslipidemias, Lipid Metabolism Disorders, Carbohydrate Inducible Hyperlipemia
- Trial name
- NCT03173495
- Testing
- FRUCTOSE, DEXTROSE, EXERCISE
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Hypertriglyceridemia, Gout
Apolipoprotein CIII Reduction Via Colchicine
The aim of this trial will be to determine an effect-size for the administration of chronic low-dose colchicine in the reduction of serum levels of triglycerides (TG), very-low density lipoproteins (VLDL), and apolipoprotein CIII…
- Conditions
- Hypertriglyceridemia, Gout, Pericarditis
- Trial name
- NCT02083510
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Hypertriglyceridemia in Type 4 Hyperlipidemia, Non Diabetic Subjects With Normoglycemia
Rosiglitazone And Fenofibrate Additive Effects on Lipids (RAFAEL)
The design of the study will be randomized, double blind trial, which will examine the effects of Rosiglitazone on the fasting triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and plasma…
- Trial name
- RAFAEL (NCT00819910)
- Testing
- Rosiglitazone, Fenofibrate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Ahmad Slim
Dyslipidemias, Hypertriglyceridemia
Dark Chocolate, Cholesterol and Microbiota
Scientific evidence shows that a major consume of flavonoids is associated with a minor risk of coronary disease and a modification of the gut microbiome profile.
- Trial name
- CHOCO-diet (NCT03850405)
- Testing
- Dark Chocolate
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bari
Hypertriglyceridaemia
Understanding Liver Fat Metabolism: Studies to Understand the Role of Dietary Sugars on Liver Fat Metabolism
High levels of fatty substances in the blood increase the risk of developing coronary heart disease and having a heart attack. The investigators know a lot about one of these fatty substances, cholesterol.
- Trial name
- NCT02478541
- Testing
- Sugar study
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Insulin Resistance
Use of Novel High-protein Food Products To Reduce Insulin Resistance
This controlled weight loss trial in adults at cardiometabolic risk (elevated triglyceride/HDL ratio) followed a randomized, cross-over design and utilized novel, high-protein pasta and cereal to examine the physiological impact…
- Trial name
- NCT02851498
- Testing
- Food product: high-protein pasta and cereal
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Arizona State University