Clinical trials: Embryo
Rabies Prevention, Rabies Exposure
Study of Intradermal Administration of PCEC Rabies Vaccine
The purpose of this study is to determine immunogenicity and safety of intradermal administration of the PCEC rabies vaccine in adults.
- Trial name
- Rabies-ID (NCT01044199)
- Testing
- PCEC rabies vaccine given intradermally, PCEC rabies vaccine administered intramuscularly
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Embryonic Mosaicism, Embryo Culture Media
Media, Morphokinetics, and Mosaicism
Embryonic aneuploidy is the underlying etiology for the majority of failed implantation and miscarriage. Preimplantation genetic screening (PGS) with transfer of a euploid embryo has been advocated as a strategy for increasing…
- Conditions
- Embryonic Mosaicism, Embryo Culture Media, Embryo Morphokinetics, Infertility
- Trial name
- 3M (NCT03503877)
- Testing
- EmbryoScope Plus, GLOBAL MEDIA, SAGE MEDIA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
EMBRYO IMPLANTATION
Endometrial Scratch Effect on Pregnancy Rates in Patients Undergoing Egg-donation IVF
Clinical trial about the effect of endometrial scratch on pregnancy rates in patients undergoing a treatment with in-vitro fertilization with donor eggs, when doing the endometrial biopsy during the cycle prior to the embryo…
- Trial name
- NCT03108157
- Testing
- Endometrial scratch
- Where
- Spain
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Procreatec
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Anxiety, Depression
Coping Intervention After Embryo Transfer
Background of the study: Undergoing an IVF or ICSI treatment is an emotional and physical burden for both the woman and her partner.
- Trial name
- NCT01701011
- Testing
- Coping intervention
- Where
- Netherlands
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Infertility, Subfertility
Effect of hCG on Receptivity of the Human Endometrium
Worldwide, 1 in 12 couples experience difficulty in getting pregnant and seek the help of assisted reproductive technologies (ART) such as in vitro fertilization (IVF-egg is fertilized by sperm outside the body), ovarian…
- Trial name
- NCT01786252
- Testing
- human chorionic gonadotropin (hCG)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Infertility, Female
Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)
This a trial designed to test whether granulocyte colony stimulating factor (G-CSF, Neupogen) can increase the rate of embryo implantation following IVF and embryo transfer.
- Trial name
- NCT01202656
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, Endometrial Disorder
Comparing Two Types of Endometrial Activation Prior to Embryo Transfer
To determine if two types of endometrial activation (Pipelle curette or Shepard catheter) prior to embryo transfer result in similar live birth rates.
- Trial name
- NCT04363879
- Testing
- Endometrial scratch with Pipelle curette, Endometrial scratch with Shepard catheter
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Infertility
Comparison Of The Embryoscope Time-Lapse System With Standard Embryo Culture
"Embryoscopes," allow for embryo culture to be performed in an automated incubation system under time lapse photography. Manufacturers of these systems (and investigators who have used these systems) claim that the availability…
- Trial name
- NCT02246309
- Testing
- Embryoscope Time Lapse System, Standard Embryo Culture
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Virus Diseases, Rabies
A Phase 3 Clinical Trial to Evaluate Long-term Immunogenicity and Boostability of Purified Chick-Embryo Cell Rabies Vaccine in Adults Following Primary Series of Pre/Exposure Prophylaxis.
The aim of this study is to evaluate the long-term (up to approx.10 years) persistence and to assess the boostability of immune responses in participants who received a primary series of accelerated or conventional rabies PrEP IM…
- Trial name
- NCT02545517
- Testing
- Rabipur, Blood sampling, Purified Chick-Embryo Cell Rabies Vaccine
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Primary Infertility
Endometrial Injury and Single Embryo Transfer
Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.
- Trial name
- NCT01851876
- Testing
- Endometrial injury
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Fertility
TiLE (Time Lapse Eeva) Clinical Trial
The purpose of the study was to explore the added value of adjunctive use of Early Embryo Viability Assessment (Eeva) with morphological grading in identifying optimal embryos for transfer.
- Trial name
- TiLE (NCT02417441)
- Testing
- Eeva
- Where
- 23 sites in Canada, Denmark and 7 more
- Volunteers
- 976 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Comparing Intra-vaginal Culture of Embryos to In-vitro Culture of Embryos With Minimal Stimulation
The purpose of this study is to evaluate implantation rate with intra-vaginal culture (IVC) with the INVOcell device versus traditional In-Vitro Fertilization (IVF) while using minimal stimulation protocols
- Trial name
- NCT02802176
- Testing
- INVOcell device, Traditional IVF
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment
The main purpose of the study was to evaluate the overall clinical value of GERI+ as an integrated embryo culture and assessment system, providing an undisturbed culture environment, continuous monitoring of embryo development…
- Trial name
- TICON (NCT03164551)
- Testing
- GERI+ incubator, Conventional incubator
- Where
- 17 sites in Canada, Denmark and 5 more
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Fertility Issues, Disclosure
Feasibility Trial of the TELL Tool Intervention
A radical paradigm shift is taking place where technology, notably the explosion in easy accessible direct-to-consumer genetic testing (e.g., 23andMe) and a high consumer interest in genealogy (e.g., Ancestry.com), has hijacked…
- Conditions
- Fertility Issues, Disclosure, Parenting
- Trial name
- NCT04841967
- Testing
- TELL Tool Intervention, eBook Attention Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Rabies
Safety and Immunogenicity (Non-inferiority) of a Purified Chick Embryo Cell Vaccine Vaccine Administered in Two Different Schedules (Conventional Versus Abbreviated Schedule)
This study investigates the safety and immunogenicity (non-inferiority) of a Purified Chick Embryo Cell Vaccine (PCECV) administered in two different schedules (conventional versus abbreviated schedule) in healthy adults 18 to 50…
- Trial name
- NCT00825305
- Testing
- Abbreviated Zagreb 2-1-1 schedule, Standard Essen 1-1-1-1-1 schedule
- Where
- China
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
in Vitro Fertilization
Embryo Transfer With Self-spent Culture Medium
Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the…
- Trial name
- NCT03728140
- Testing
- Self-spent Culture Medium
- Where
- China
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Bin Wu
Clinical Pregnancy After Single Embryo Transfer
Embryo Selection by Time Lapse Monitoring for Single Embryo Transfer ("SET")
A multiple pregnancy is an undesired outcome of assisted reproduction. Current embryo selection technologies are inefficient in identifying the embryo with the highest implantation potential.
- Trial name
- NCT01694641
- Testing
- time-lapse morphokinetic evaluation
- Where
- 2 sites in Hungary
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Dunamenti REK Istenhegyi IVF Center
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco