Clinical trials: Embryo
Oligospermia, DNA Damage
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
In patients with oligospermia in the ejaculate or previous ICSI failures if it concurs with high DNA fragmentation, it has been hypothesized that the use of sperm obtained from the testicle would improve the clinical results…
- Conditions
- Oligospermia, DNA Damage, IVF, ICSI
- Trial name
- NCT04795440
- Testing
- Testicular biopsy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación IVI
Recurrent Pregnancy Loss
Establishment of Special Disease Cohort for RPLand Study of Impact Mechanism of Early Embryo Development
Recurrent pregnancy loss (RPL) is a refractory disease with diverse etiologies, complex pathogenesis and limited therapeutic options. Current tests and treatments lack uniform specifications.
- Trial name
- NCT05186207
- Testing
- abnormal pre-pregnancy test results that need clinical intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Infertility Assisted Reproductive Technology
Artificial Shrinkage of Fresh Blastocysts
The aim of the study is to determine if collapsing an embryo (or making it fold compactly by taking away its fluid) before the transfer in the uterine cavity improves pregnancy rates in assisted reproductive technology (ART).
- Trial name
- BlastoCollapse (NCT02988544)
- Testing
- Artificial shrinkage
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Infertility
Study of Assisted Hatching of Cleavage Stage Embryos
The purpose of this study was to determine if assisted embryo hatching can improve pregnancy rates for good prognosis patients undergoing in vitro fertilization (IVF) with day 3 embryo transfer.
- Trial name
- NCT00120549
- Testing
- Assisted embryo hatching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility
Preparing and Timing of the Endometrium in Modified Natural Cycle Frozen-thawed Embryo Transfers
The increasing use of FET emphasizes the importance of preparing and timing the endometrium in FET cycles, however there is no consensus on luteal phase progesterone supplementation in mNC-FET and the optimal day of blastocyst…
- Trial name
- NCT03795220
- Testing
- Lutinus + transfer day 6, Lutinus + transfer day 7, No Lutinus + transfer day 6
- Where
- Denmark
- Volunteers
- 679 people
- Sponsor
- Anja Bisgaard Pinborg
Infertility
Injection of Hormone to Enhance Implantation in Embryo Transfer After IVF
The endometrium is deprived of signals form the embryo in IVF conditions. Studies suggest that placing HCG into the uterus prior to embryo transfer can enhance implantation.
- Trial name
- NCT01986374
- Testing
- HCG is introduced
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Servy Massey Fertility Insititute
Infertility
Comparison of Vaginal and Intramuscular Progesterone in Vitrified-warmed Blastocyst Transfer Cycles
The aim of this study is to test the hypothesis that the pregnancy rates of women (ages 18-50 years) undergoing transfer of vitrified-warmed blastocysts (frozen at less than 41 years of age) as part of their IVF treatment are not…
- Trial name
- NCT02772120
- Testing
- Vaginal progesterone gel (Crinone® 8%), Intramuscular Progesterone
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Advanced Parkinson's Disease
Phase 1 Safety and Tolerability Study of MSK-DA01 Cell Therapy for Advanced Parkinson's Disease
This clinical trial is designed to test whether surgically injecting nerve cells that make dopamine into the brain of Parkinson's disease patients is safe, and to monitor for potential side effects.
- Trial name
- NCT04802733
- Testing
- MSK-DA01, MSK-DA01 Cell Delivery Device
- Where
- 3 sites in United States, Canada
- Volunteers
- 12 people
- Sponsor
- BlueRock Therapeutics
Infertile
Prospective Study of an Human Endometrial Receptivity Test
Evaluation of endometrial receptivity is a crucial step in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) programs.
- Trial name
- Win-Test (NCT04192396)
- Where
- France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Montpellier
Infertility
Embryo DNA Repair Capacity Project
The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA
- Trial name
- NCT03953859
- Testing
- double strand break
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Sterility, Infertility
Oral Versus Vaginal Progesterone in the Luteal Support in Cryo-warmed Embryo Transfer Cycles
In IVF/ICSI cycles, the progesterone levels induced by ovarian stimulation are low, therefore the luteal phase is supported by progesterone.
- Trial name
- NCT03619707
- Testing
- Progesterone
- Where
- Lebanon
- Volunteers
- 157 people
- Sponsor
- American University of Beirut Medical Center
Embryo Development
Effect of Abstinence Duration on Embryo Development
The aim the investigators study is to analyze the embryo development if oocytes of the participants are injected with sperm from a longer or shorter (2 hours) abstinence duration.
- Trial name
- NCT03323892
- Testing
- second masturbation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Perifollicular Vascularity Assessment in in-Vitro Fertilization
On February 2004, a law (n. 40/2004) regulating assisted reproduction techniques (ARTs) was approved in Italy. This law aimed to regulate the treatment of infertility in Italy, contains several restrictions, such as the…
- Trial name
- NCT00458380
- Testing
- Controlled ovarian stimulation, perifollicular vascularity assessment, IVF, embryo transfer.
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University Magna Graecia
Infertility
Comparing Intra-vaginal Culture of Embryos to In-vitro Culture of Embryos With Minimal Stimulation
The purpose of this study is to evaluate implantation rate with intra-vaginal culture (IVC) with the INVOcell device versus traditional In-Vitro Fertilization (IVF) while using minimal stimulation protocols
- Trial name
- NCT02802176
- Testing
- INVOcell device, Traditional IVF
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Female
Comparison of in Vitro Fertilization Rates of Oocytes and Embryo Development Using Two Techniques of Semen Processing
The investigators propose to assess one method of sperm selection based on the characteristics of spermatozoa recently introduced: Sperm Selection Assay, which used a gradient of concentration of progesterone to act as…
- Trial name
- NCT03186170
- Testing
- SSA sperm selection
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Letrozole, Infertility, Female
The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)
The goal of this single center, non-blinded, randomized controlled clinical trial to comparison of pregnancy outcomes and perinatal outcomes in patients undergoing IVF treatment (including ICSI) with FET with letrozole-induce…
- Trial name
- NCT06006091
- Testing
- Letrozole
- Where
- China
- Volunteers
- 858 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Infertility, Invitro Fertilization
Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure
Women with history of previous IVF cycle failure will be subjected to a fresh IVF cycle. At the time they will be undergoing embryo transfer, 50 IU of human chorionic gonadotropins diluted in 0.025ml of tissue culture media will…
- Trial name
- NCT02329197
- Testing
- Human Chorionic Gonadotropin (HCG)
- Where
- Egypt
- Volunteers
- 380 people
- Sponsor
- Mansoura University
Endometrioma
Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients
Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm \&with or without GnRh agonists for all endometrioma patients
- Trial name
- GnRh (NCT02737800)
- Testing
- endometrioma aspiration, GnRh agonist ( Decapeptyl ), standard long stimulation protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kasr El Aini Hospital
Infertility
In Vitro Human Embryo Culture System
The purpose of this study is to compare the development of human embryos grown in a conventional culture dish to those grown in a new embryo culture device known as the SMART System.
- Trial name
- NCT00985218
- Testing
- SMART System, Culture dish
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Incept BioSystems, Inc.
Human Embryo Culture
Effect of Protein Concentration on Human Embryo Development
Protein Concentration in Human Embryo Culture Media remains assigned to the manufacturers with no clear evidence on which concentration is ideal.
- Trial name
- PCHED (NCT03630848)
- Testing
- Effect of Protein on Blastocyst Development
- Where
- 2 sites in Egypt
- Volunteers
- 1,536 people
- Sponsor
- Ibn Sina Hospital