Clinical trials: Embryo Culture
Infertility, In Vitro Fertilization
Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates
Forty-five infertile women undergoing in vitro fertilization treatment were managed by uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer.
- Trial name
- NCT00730496
- Testing
- uterine cavity injection of day 2 embryo culture supernatant
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shen-Zhen City Maternity and Child Healthcare Hospital
Infertility
Comparison of Alternative Embryo Culture Systems
This study will compare two alternative embryo culture systems. Embryos from each patient will be randomly assigned to one of two systems. One group will be cultured conventionally in oil-covered droplets in dishes.
- Trial name
- NCT02028897
- Testing
- Conventional embryo culture, Enclosed embryo culture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility, Embryo Culture
Oxygen Tension on Human Embryonic Development
In mammals, uterine environment is at low oxygen concentration (2-8% O2). Thus, human embryo culture under low O2 tension (5%) is now recommended by European Society of Human Reproduction and Embryology (ESHRE) revised guidelines…
- Conditions
- Infertility, Embryo Culture, Hypoxia
- Trial name
- EmbryOx (NCT03964805)
- Testing
- 20% oxygen, 5% oxygen, 20 % and 5 % oxygen
- Volunteers
- 773 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Embryo Culture, Embryo Culture Media
Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles
This is a prospective, multicenter, randomized controlled clinical trial designed to evaluate whether a fully undisturbed closed embryo culture system can improve the developmental potential of embryos cultured in vitro and…
- Conditions
- Embryo Culture, Embryo Culture Media, Embryo Quality
- Trial name
- Embryos UECS (NCT07522281)
- Testing
- Gems FEM fertilization medium + Geri incubator+Gems one-step medium, Vitrolife fertilization medium+benchtop incubator + Vitrolife sequential culture media
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility (IVF Patients), Embryo Morphokinetics
IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol.
- Conditions
- Infertility (IVF Patients), Embryo Morphokinetics, Progestins Primed Ovarian Stimulation
- Trial name
- NCT07409493
- Testing
- Progestin-Primed Ovarian Stimulation, Antagonist protocol for IVF
- Where
- Vietnam
- Volunteers
- 148 people
- Sponsor
- Hanoi Medical University
Infertility, Aneuploidy Rate
PGTai Results for Embryos Cultured in Sequential Versus Single Step Media
A prospective cohort study undergoing ICSI at a private fertility center in Egypt
- Conditions
- Infertility, Aneuploidy Rate, Mosaicism
- Trial name
- NCT04485910
- Testing
- Single step media, Sequential media
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ganin Fertility Center
Infertility
TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment
The main purpose of the study was to evaluate the overall clinical value of GERI+ as an integrated embryo culture and assessment system, providing an undisturbed culture environment, continuous monitoring of embryo development…
- Trial name
- TICON (NCT03164551)
- Testing
- GERI+ incubator, Conventional incubator
- Where
- 17 sites in Canada, Denmark and 5 more
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Female Infertility, Embryo Development
Day-4 Embryo Defragmentation: Blastocyst Rate and clInical Outcomes
Background: Embryo fragmentation is one of the main morphological parameters assessed during in vitro culture in assisted reproductive technology (ART).
- Conditions
- Female Infertility, Embryo Development, In Vitro Fertilization
- Trial name
- DEBRIS (NCT07500337)
- Testing
- Mechanical embryo defragmentation at Day 4 (morula stage), Standard embryo culture without intervention
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Momo Fertilife
Infertility
Blastocyst Culture Using Time-lapse in Good Prognosis IVF Patients and Elective Single Embryo Transfer
Choosing the best embryo for transfer has become the major challenge in in vitro fertilization (IVF). Morphology alone is obviously not enough and time-lapse incubation has added embryo development kinetics as another selection…
- Trial name
- NCT01773603
- Testing
- Embryoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Murat Çetinkaya
Embryo Culture
Incubator Temperature for Culturing Human Embryos
Incubator temperature is one of the most precious variables in IVF labs. When the IVF started, almost all incubator temperatures were set at 37 degrees which mimic in vivo conditions.
- Trial name
- NCT01706900
- Testing
- Incubator Temp set to 36.5 degree, Incubator Temp 37 degree
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Infertility, Pregnancy Outcome, Live Birth
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
Human conception in vivo occurs in a complex milieu that includes proteins. It has been speculated that the addition of proteins more complex than human serum albumin to culture media may improve IVF outcomes.
- Conditions
- Infertility, Pregnancy Outcome, Live Birth, In Vitro Fertilization
- Trial name
- SSS (NCT00708383)
- Testing
- 10% SSS embryo culture medium protein supplementation, 0.5% HSA embryo culture medium protein supplementation
- Where
- 2 sites in United States
- Volunteers
- 538 people
- Sponsor
- Texas Health Resources
Polycystic Ovary Syndrome, Assisted Reproduction
Mitochondrial DNA in Fresh Versus Frozen Embryo Culture Media of PCOS Women Undergoing In Vitro Fertilization
Ninety women with PCOS candidate for ICSI were randomized to 2 groups:Group A: fresh samples of PCOS patients undergoing IVF (no= 45) and Group B: frozen samples of PCOS patients undergoing IVF (no= 45).
- Trial name
- NCT03820167
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Infertility, Miscarriage
Ism1 Versus EmbryoGen Media for Embryo Culture in Previous Pregnancy Loss Cases
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the live birth rate in IVF patients with a previous history of pregnancy loss.
- Trial name
- NCT01689428
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biogenesi
Infertility
EnMotion, Embryo's Natural Motion
The purpose of the study is to determine if a dynamic embryo microenvironment impacts embryo development and reproductive potential in comparison to static culture.
- Trial name
- EnMotion (NCT02467725)
- Testing
- Dynamic culture platform
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
to Evaluate the Feasibility and Accuracy of Using cfDNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for PGD
Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis
This study aims to evaluate the feasibility and accuracy of using cfDNA analysis of spent embryo culture media as a non-invasive approach for PGD. Specifically, the objectives of the study are: 1.
- Trial name
- NCT07076719
- Testing
- Trophectoderm (TE) Biopsy, Non-invasive Preimplantation Genetic Diagnosis
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- Sohag University
Embryo Development, Blastocyst IVF
Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate
This prospective study aims to compare the effects of light and heavy paraffin oil in embryo culture during in vitro fertilization (IVF).
- Conditions
- Embryo Development, Blastocyst IVF, Pregnancy Rates, IVF
- Trial name
- NCT06838923
- Testing
- Light Paraffin Oil, Heavy Paraffin Oil
- Where
- Vietnam
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
ART
Evaluation of a Closed Assisted Reproductive Technology (ART) Station Versus an Open Flow Cabinet
There is not yet a standardized system of human embryonic culture in vitro. In addition, technical improvements continually appear.
- Trial name
- NCT03343938
- Testing
- Embryo handling in a closed station
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Vida Recoletas Sevilla
Embryo Development
Culture Media and Blastocyst Development
The aim of this non-interventional study is to compare the blastulation rate per fertilized oocyte in two different single step culture media commercially available (GEMS and Irvine culture media).
- Trial name
- NCT03497052
- Testing
- In vitro culture in medium 1, In vitro culture in medium 2
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Clinica Valle Giulia
Single Embryo Transfer, Fertilization in Vitro
Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).
Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure.
- Trial name
- TRABLAN (NCT06177613)
- Testing
- Blank culture transfer
- Where
- 7 sites in France, Reunion
- Volunteers
- 1,154 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes