Clinical trials: Embryo Quality
Infertility
Improving IVF Embryo Quality Grading Using Polarized Light
Selecting one or two IVF embryos with the highest potential to implant is extremely important for the success of the treatment- obtaining pregnancies and avoiding multi-fetal gestations.
- Trial name
- NCT01601249
- Testing
- Embryo selection based on polscope grading or morphology
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
In Vitro Fertilization, Assisted Reproductive Techniques
Optimizing IVF Treatment - the Impact of Time-lapse Culture and Preimplantation Factor (PIF) on Embryo Development.
The aims of this study are to evaluate: 1. the possible effect of time-lapse culture from day zero (day of oocyte retrieval) on fertilisation rates and embryo quality in standard IVF. 2.
- Trial name
- NCT02222831
- Testing
- Day 0 denudation and time lapse culture on IVF-oocytes.
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
Vitamin D Deficiency
Follicular Fluid, Bioavailable Vitamin D and Embryo Quality Markers
To determine the correlation between bioavailable Vitamin D values and euploid status of the embryos in larger size follicles from UAE women undergoing in vitro fertilization procedures.
- Trial name
- NCT03073720
- Where
- United Arab Emirates
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Autologous Platelet-rich Plasma to Improve Responsiveness and Embryo Quality in Patients With Poor Ovarian Response
This study was a prospective randomized controlled trial. Patients with POR who were aged <40 years and underwent IVF/ICSI with assisted ovulation induction at our hospital were enrolled in the study.
- Trial name
- NCT05105724
- Testing
- PRP
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanjing University
Embryo
Effect of Degranulation Needle With Different Diameters on the Rate Good Embryo in IVF
Good-quality embryos are critical for the success of in vitro fertilization (IVF). But, to date, there is no report of the effect of different diameters denuding pipette on the embryos quality.
- Trial name
- NCT03810040
- Testing
- 140 microns denuding pipette, 150 microns denuding pipette
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Fertilization in Vitro
Ejaculation Abstinence Time and Assisted Reproductive Technology Outcomes
The goal of this clinical trial is to learn if reducing the ejaculation abstinence time can improve the outcome of assisted reproductive technology.
- Trial name
- NCT06410417
- Testing
- Shorten abstinence time
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, Endometriosis
The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.
In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy.
- Trial name
- NCT01682642
- Testing
- Zoladex
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Fertility
The Influence of Different Concentrations of Glucose in Culture Media on Fertilization and Embryo Quality
The aim of this study is to examine whether incubation of human oocytes until pronuclear stage, in different culture media containing high and low concentrations of glucose affect fertilization differently, not only in standard…
- Trial name
- NCT00606073
- Testing
- Universal IVF Medium + ISM1 Medium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Ovarian Hyperstimulation Syndrome
Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS
The aim of this work is to study the value of GnRH antagonist subcutaneous administration as an alternative to coasting in prevention of severe OHSS and its impact on embryos quality \& the outcome of ICSI.
- Trial name
- NCT03996434
- Testing
- Gonadotropin, Antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- ClinAmygate
Infertility
Availability of Poor Quality Embryos
The purpose of this study is to explore a method to identify the viability of day-3 poor quality embryos
- Trial name
- Availability (NCT01715545)
- Where
- China
- Volunteers
- 481 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Culture Media, DNA
Cell-free DNA: a Non-invasive Test for Assessing Embryo Quality
In the present project we propose to deeply characterize nuclear and/or mitochondrial DNA in embryo culture medium, in order to investigate whether both cell-free nucleic acid types may provide additional, reliable, predictive…
- Trial name
- NCT01397136
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Laser Assistance to Improve ICSI Outcome
Laser Assisted ICSI; Has it Role Whatsoever?
laser-assisted ICSI (LA-ICSI) was described to be a new method combining a less invasive ICSI technique with assisted hatching.This procedure is usually used for MII oocytes possessing oolemma breakage difficulties, but why not…
- Trial name
- NCT04455412
- Testing
- Laser Assisted ICSI
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Royal Fertility Center, Egypt
Male Fertility, Testicular
Use of the SiDTM v2.0 Algorithm to Assist Embiyologists in Sperm Selection During ICSI Procedures
Infertility is defined as a failure of a couple to achieve a pregnancy after 12 or more months of unprotected intercourse. Males are found to be solely responsible for 20-30% of infertility cases but contribute to 50% of cases…
- Conditions
- Male Fertility, Testicular, Sperm Parameters in Fertile and Infertile Men, Sperm Selection
- Trial name
- SID_3 (NCT07163754)
- Testing
- Automated Sperm Selection, Conventional Sperm Selection
- Volunteers
- 100 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Female Infertility, Oocyte Competence
Adipose Stem Cell Mitochondria Supplementation to Oocytes (ASCENT)
The purpose of this study is to investigate the potential of autologous adipose stem cell (ASC) mitochondrial transfer (ASCENT) to oocytes along with intracytoplasmic sperm injection (ICSI)as a means of enhancing embryo…
- Conditions
- Female Infertility, Oocyte Competence, Mitochondria, Recurent Implantation Failures
- Trial name
- NCT07066267
- Testing
- Experimental
- Where
- Sri Lanka
- Volunteers
- 20 people
- Sponsor
- Sunkaky Medical Cooperation
Ovarian Stimulation
Dehydroepiandrosterone Supplementation for Poor Responder Patients During in Vitro Fertilization Treatment
The aim of this study was to evaluate the effect of dehydroepiandrosterone supplementation on in vitro fertilization performance and outcome among poor-responder patient.
- Trial name
- NCT01145144
- Testing
- dehydroepiandrosterone crystalline fine powder
- Where
- 2 sites in Israel
- Sponsor
- Meir Medical Center
Infertility, Female, IVF
MVA to Improve the Pregnancy Outcome in Aged Infertility Women With Assisted Reproductive Technology
The goal of this clinical trial is to test MVA on improving pregnancy outcome in elderly infertile patients undergoing invitro fertilization (IVF).
- Conditions
- Infertility, Female, IVF, Reproductive Disorder, Oocyte
- Trial name
- NCT05788822
- Testing
- Mevalproic acid
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Nanjing University
Embryo Hypoxia
The Effect of Low Oxygen Tension on the Early Development of Human Embryo in IVF/ICSI
To investigate the effect of low oxygen tension during in vitro culture in terms of embryo quality and outcomes of pregnancy in vitro fertilization/ Intracytoplasmic sperm injection
- Trial name
- NCT01983696
- Testing
- 5% oxygen concentration
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanxi Provincial Maternity and Children's Hospital
Infertility, Female, Luteinizing Hormone (LH)
Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatment
This randomized controlled trial aims to evaluate whether supplementation with exogenous luteinizing hormone (LH) can improve embryo quality in patients undergoing in vitro fertilization (IVF) with a long gonadotropin-releasing…
- Trial name
- ELH-IVF (NCT07128394)
- Testing
- Recombinant Luteinizing Hormone (rLH), Recombinant Follicle-Stimulating Hormone (rFSH), Gonadotropin-Releasing Hormone Agonist (GnRH-a)
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Nanjing University