Clinical trials: Embryo Quality
Infertility, Pregnancy Outcome, Live Birth
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
Human conception in vivo occurs in a complex milieu that includes proteins. It has been speculated that the addition of proteins more complex than human serum albumin to culture media may improve IVF outcomes.
- Conditions
- Infertility, Pregnancy Outcome, Live Birth, In Vitro Fertilization
- Trial name
- SSS (NCT00708383)
- Testing
- 10% SSS embryo culture medium protein supplementation, 0.5% HSA embryo culture medium protein supplementation
- Where
- 2 sites in United States
- Volunteers
- 538 people
- Sponsor
- Texas Health Resources
IVF/ICSI, Frozen Embryo Transfer
Cumulus Cell Mitochondrial Activity as a Non-invasive Marker of Embryo Quality (FLIM)
This study aims to test the extent of association of FLIM parameters of cumulus cells with clinical outcomes (clinical pregnancy, ongoing pregnancy at 12 weeks, and live birth) of the embryos that result from the enclosed oocytes.
- Conditions
- IVF/ICSI, Frozen Embryo Transfer, Cumulus Cell, Fluorescence Lifetime Imaging Microscopy
- Trial name
- NCT05332769
- Testing
- FLIM parameters
- Where
- Vietnam
- Volunteers
- 200 people
- Sponsor
- Mỹ Đức Hospital
Infertility, Female
DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore
Since preimplantation genetic testing (PGT) is being more frequently requested from patients as women pursue infertility treatments at an advanced age with a poorer prognosis, sometimes physicians are compelled to perform several…
- Trial name
- NCT03291821
- Testing
- human menopausal gonadotropin, GnRH antagonist, GnRH analog
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- IVI Madrid
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction
Female Infertility
Female Fertility, Environmental Agents and Stress Oxidant
Synthetic products used in industrial, pharmaceutical, agro-alimentary or agricultural fields are found in our environment. Thus, humans could be simultaneously exposed to several of these pollutants.
- Trial name
- FERTENOX (NCT04866329)
- Testing
- Blood sample, Urine sample, Follicular fluid and granulosa cells sample
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Tours
Infertility, Aneuploidy
Anti-Müllerian Hormone and Embryo Aneuploidy
The goal of this observational study is to determine is there an association between the rates of aneuploidy and the different ranges of serum Antimullerian hormone (AMH) levels.
- Trial name
- NCT05723016
- Testing
- preimplantation genetic test for aneuploidies (PGT-a)
- Where
- Chile
- Volunteers
- 300 people
- Sponsor
- Clinica de la Mujer Medicina Reproductiva, Chile
Infertility, Female
Timing of COC Denudation and Embryo Quality
The relation between the timing of COC denudation and oocyte /embryo quality is controversial. The aim of this study is to examine whether timing of denudation of sibling oocytes has any effect on embryo quality.
- Trial name
- NCT03813745
- Testing
- early denudation, late denudation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acıbadem Atunizade Hospital
Infertility
The Effect of Follicular Flushing on Oocyte Retrieval Rate and Embryo Quality
Researchers will investigate the effect of flushing according to follicle size on the success of obtaining oocytes from a single follicle.
- Trial name
- NCT05584436
- Where
- Turkey (Türkiye)
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Spermatic Parameters, Embryonic Kinetics
Impact of Nuclear Human Sperm Quality on Embryo Development
To date, none study shows the impact of human spermatozoa nuclear alteration on embryonic development kinetic with morpho-kinetics tools.
- Trial name
- PRIMOSPERMO (NCT03320590)
- Testing
- Time Lapse (material to observe embryonic development)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility, Reproductive Techniques, Assisted
"Study of the Effects of Serum and Follicular Fluid Relaxin Levels on Ovarian Function in IVF Cycles"
The study evaluated the effect of serum relaxin and follicular fluid levels on the number and quality of oocytes, fertilization, the number and quality of the embryos in IVF protocols.
- Conditions
- Infertility, Reproductive Techniques, Assisted, Oocyte Maturation
- Trial name
- "Relaxifert" (NCT04458454)
- Testing
- Relaxin ELISA Kit
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Couple Sterility
Effect of Myoinositol Treatment of Spermatozoa on in Vitro Fertilization Outcome
In the present trial, the investigators aim to evaluate whether semen myo-inositol (MI) treatment is able to improve IVF outcomes.
- Trial name
- MI_ICSI (NCT02050672)
- Testing
- Myo-inositol, untreated
- Where
- Italy
- Volunteers
- 249 people
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Infertility, Fertility
Mono-menotropins Versus rFSH Protocol on Embryo Quality
This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic screening (PGS) of embryos to achieve pregnancy.
- Trial name
- NCT02418533
- Testing
- menotropin, Recominant Follicle Stimulating Hormone (rFSH)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Infertility,Female
Growth Hormone Adding to Controlled Ovarian Hyperstimulation for Improving Embryo Quality
GH plays an important role in the synthesis of ovarian steroid hormone and follicular development as a paracrine hormone.GH can regulate the growth hormone receptor and strengthen the function of mitochondria to improve the…
- Trial name
- NCT03966339
- Testing
- Growth hormone
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Infertility, Female
Impact of Gonadotrophin Releasing Hormone Analogues on Oocyte and Embryo Quality
The first In-Vitro Fertilization cycles were performed in natural unstimulated cycles. Today gonadotrophins are administered to induce multiple follicular development and controlled ovarian hyperstimulation.
- Trial name
- NCT03139474
- Testing
- Gonadotropin-Releasing Hormone Analogue, Gonadotropin releasing hormone antagonist
- Volunteers
- 120 people
- Sponsor
- Assiut University
Infertility, Ovulation Induction
A Clinical Trial to Determine the Effect of Lutropin Alfa on Embryo Quality and Implantation Rate in Advanced Reproductive Age
This is a multicentric, open, randomized, comparative trial aimed to assess the influence of recombinant luteinizing hormone (r-LH) supplementation during controlled ovarian stimulation (COS) in advanced reproductive age in terms…
- Trial name
- NCT01075815
- Testing
- Recombinant human luteinizing hormone (rhLH), Recombinant follicle-stimulating hormone (rFSH)
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome
Myo-Inositol for Ovarian Stimulation and ICSI Outcomes in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect ovarian function, insulin sensitivity, and fertility.
- Trial name
- NCT07779850
- Testing
- Myo-Inositol, Folic Acid
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kafrelsheikh University
Poor Ovarian Response
the Effect of Transcutaneous Electrical Acupoint Stimulation on the Quality of Oocyte on Poor Ovarian Response(POR)
Patients in experimental group will be given transcutaneous electrical acupoint stimulation (TEAS) treatment for 12 weeks prior to controlled ovarian stimulation (COS).The patients will be given three times acupuncture every week…
- Trial name
- POR (NCT03994614)
- Testing
- TEAS
- Where
- China
- Volunteers
- 92 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Low Ovarian Reserve
The Effect of Growth Hormone in Assisted Reproductive Technology Clinical Outcome of Poor Responder
Assisted reproduction treatment in patients with low ovarian reserve is a big difficult clinical problem. Growth hormone (GH) is crucial in the development of follicles since preantral follicle to ovulation and can promote…
- Trial name
- NCT03027843
- Testing
- Growth Hormone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Repetition Failure
Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.
Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to persistent poor embryo quality.Mitochondria…
- Trial name
- NCT03639506
- Testing
- autologous mitochondria transplantation, autologous mitochondria from bone marrow mesenchymal stem cells into oocyte as well as intracytoplasmic sperm injection (ICSI), intracytoplasmic sperm injection (ICSI)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University