Clinical trials: Embryo Quality
Embryo Disorder
Pilot Study: hCG Secreted by Blastocyst as Potential Marker of Embryo Quality
hCG is a hormone produced very early by the pre-embryo, but not by the oocyte. It has a pivotal role in the trophoblast differentiation, and embryo implantation as well as the corpus luteum support.
- Trial name
- NCT04736160
- Testing
- collect data
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- IVI Vigo
IVF, Oocyte Maturation Defect 1
IVF Outcome Following Progestogen Ovarian Stimulation
The new strategy is by using the progestogen to block the luteinizing hormone(LH) surge either endogenous during luteal phase stimulation, or exogenous in the follicular phase i.e progestin primed ovarian stimulation (PPOS).
- Conditions
- IVF, Oocyte Maturation Defect 1, Clinical Pregnancy Rate, Ovarian Hyperstimulation
- Trial name
- NCT04175990
- Testing
- Dydrogesterone Pill
- Where
- Malaysia
- Volunteers
- 155 people
- Sponsor
- National University of Malaysia
Oocyte Competence
Modulation Contrast Microscopy Imaging for Oocyte Quality Assessment
The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes).
- Trial name
- NCT03683290
- Testing
- Image acquisition and analysis
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
All Patients Undergoing Infertility Treatment
Retrospective Database Studies
Data collection and comparison of relationships between patient demographics, stimulation protocols and outcomes, retrieval and transfer outcomes, number and quality of oocytes and embryos retrieved and transferred, pregnancy…
- Trial name
- NCT01219296
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Cylinical Embryo, Oligospermia
Sperm Pathology Samples and Morphokinetics
The embryo kinetics may be a new prognostic factor for choosing the embryos with the highest implantation potential. In order to identify the factors that may affect the rate of embryo cleavage, there are many studies about…
- Trial name
- NCT02155179
- Where
- 2 sites in Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
IVF, Infertility
Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study
GM508 CultActive is a bicarbonate buffered reagent and ready-to-use designed to investigate oocytes of patients with failed fertilization after previous Intracytoplasmatic Sperm Injection cycles.
- Conditions
- IVF, Infertility, Artificial Oocyte Activation
- Trial name
- GM508 in IVF (NCT05722067)
- Testing
- calcium ionophore
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Chang Gung Memorial Hospital
Infertility, IVF
Quality of Human Embryos in IVF, Culturing in Differentiated Oxygen
The goal of this clinical trial is to evaluate the importance of differential O2 tension to the developing embryos. As a secondary aim, we investigate the levels of reactive oxygen species (ROS) in spent media from the developing…
- Conditions
- Infertility, IVF, Embryo
- Trial name
- NCT05737381
- Testing
- Differential oxygen tension
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Infertility
Embryo QUAlity in Ovarian Stimulation With hMG.
Ovarian stimulation (OS) is a key component of IVF, aimed at increasing oocyte yield and improving embryo development potential.
- Trial name
- EQUAM (NCT07691073)
- Testing
- 10 mcg of follitropin-delta + 150 of hMG, 5 mcg of follitropin-delta + 225 of hMG
- Where
- 4 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Fundacion Dexeus
Ovarian Reserve, SARS-CoV-2 Infection
Effect of Sars-cov-2 on Donor Oocyte Quality and Quantity, a Multicenter Retrospective Study.
Purpose: To determine the impact of SARS-CoV-2 infection and immunization on ovarian response to controlled ovarian stimulation (COS) and embryo development after in vitro fertilization (IVF) Methods: A retrospective multicentric…
- Conditions
- Ovarian Reserve, SARS-CoV-2 Infection, Blastocyst
- Trial name
- NCT05562479
- Testing
- Sars Cov 2 infection, Sars Cov 2 vaccination
- Where
- Colombia
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Novafem
Infertility, Female, Anxiety State
Women's Quality of Life, Sexual Life and Psychological State in Patients Undergoing Embryo Transfers
Women's quality of life, sexual life and psychological state would affect the success of embryo transfer. The primary purpose of the study is to compare women's quality of life, sexual life and psychological state using validated…
- Conditions
- Infertility, Female, Anxiety State, Depression, Quality of Life
- Trial name
- NCT04131452
- Testing
- Filling out the forms including IDAS-II, BAI, SF-36 and FSFI
- Where
- Turkey (Türkiye)
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Bahceci Health Group
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Fertility
Natural Cycle Versus Stimulated Cycle Before Frozen Embryo Transfer
Embryo freezing is a technique used regularly to optimize the pregnancy rate in case of infertility. This method is performed in presence of supernumerary embryo(s) after fresh transfer, or after freeze all embryos in case of…
- Trial name
- SONTEC (NCT02834117)
- Testing
- natural cycle, moderate ovarian stimulation
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Dr Massin Nathalie
Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer
Correlation Of Clinical Outcomes After Transfer Of Good-Quality Morphology Embryos In Patients With A Favorable Prognosis And Non-Invasive Preimplantation Genetic Testing For Aneuploidy (NiPGT-A) Results
Non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) is an emerging approach that analyzes embryonic cell-free DNA (cfDNA) released into the spent culture medium (SCM) to assess chromosomal status without…
- Conditions
- Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer, Embryo Diagnosis and Selection
- Trial name
- NCT07700602
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Infertility, Poor Ovarian Reserve
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
- Conditions
- Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization
- Trial name
- NCT07020546
- Testing
- Ovarian Platelet-rich plasma (PRP) injections
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Embryo Development
Impact of Culture Conditions on the Embryo Quality
The purpose of this study is to compare different culture conditions. The effect of the type of incubator (standard versus mini-incubator) and the effect of the oxygen concentration (5% versus 20%) will be evaluated on the embryo…
- Trial name
- NCT01767805
- Testing
- Standard incubator, Mini incubator, 5% oxygen
- Where
- 2 sites in Belgium
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility
IMPACT OF POLYCYCLIC AROMATIC HYDROCARBONS (PAH) ON IN VITRO FERTILIZATION
The main objective of this study is to highlight a relationship between exposure to PAHs, genotoxic effect biomarkers on spermatozoa and follicular cells, as well as embryonic quality and embryo implantation rates at a given…
- Trial name
- NCT03914859
- Testing
- IN VITRO FERTILIZATION
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infertility, Female, ART
Effects of Low LH Serum Levels on Ovarian Pick-up Outcome
Luteinizing hormone (LH) plays a key role for normal follicular development and oocyte maturation in controlled ovarian stimulation.
- Trial name
- NCT05755529
- Volunteers
- 43 people
- Sponsor
- University of Palermo