Clinical trials: Embryonal Neoplasm
Neuroblastoma, Pheochromocytoma
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma
The purpose of this research study is to find how active and safe 131 I-MIBG is in patients with resistant neuroblastoma, malignant pheochromocytoma and malignant paraganglioma.
- Trial name
- NCT00107289
- Testing
- iobenguane I 131
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Advanced Melanoma, Metastatic Melanoma
PH 1 Biomarker Study of Nivolumab and Ipilimumab and Nivolumab in Combination With Ipilimumab in Advanced Melanoma
The purpose of this study is to evaluate pharmacodynamic changes of Nivolumab and Nivolumab in combination with Ipilimumab treatment on the biomarkers measured in the peripheral blood and tumor tissues of subjects with advanced…
- Trial name
- PD-1 (NCT01621490)
- Testing
- Nivolumab, Ipilimumab
- Where
- 14 sites in United States, Netherlands and 1 more
- Volunteers
- 170 people
- Sponsor
- Bristol-Myers Squibb
Glioma, Other Solid Tumours
A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours
This is a phase 1/2A, open label, non-randomized study in patients with advanced solid tumours including malignant glioma
- Trial name
- NCT01792310
- Testing
- LAM561
- Where
- 5 sites in Spain, United Kingdom
- Volunteers
- 54 people
- Sponsor
- Laminar Pharmaceuticals
Metastatic Melanoma, Cutaneous Melanoma
Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma
This was a Phase 2, open-label study of KW2871 (ecromeximab) in combination with high-dose interferon-α2b (HDI) in patients with metastatic melanoma.
- Trial name
- NCT00679289
- Testing
- HDI, KW2871
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Ludwig Institute for Cancer Research
Melanoma
Peptide Vaccination for Patients at High Risk for Recurrent Melanoma
This study will examine the effectiveness and side effects of an experimental vaccine to prevent recurrence of melanoma. The likelihood of melanoma returning is higher in patients who have melanoma lesions deep in the skin, in…
- Trial name
- NCT00059475
- Testing
- Glycoprotein 100 (GP100): 209-217 (210M), Interleukin-2 (IL-2), Montanide ISA 51
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- National Cancer Institute (NCI)
Melanoma (Skin)
Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of tretinoin and/or fenretinide may be an effective way to prevent the recurrence or further…
- Trial name
- NCT00003601
- Testing
- fenretinide, tretinoin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Eastern Cooperative Oncology Group
Neuroblastoma
High-Risk Neuroblastoma Chemotherapy Without G-CSF
Patients will be asked to participate in this study because patients have been diagnosed with high-risk neuroblastoma, a common childhood cancer which has aggressive features. If left untreated, high-risk neuroblastoma is fatal.
- Trial name
- SPRING (NCT02786719)
- Testing
- Topotecan, Cyclophosphamide, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Lymphedema of Leg, Cancer of Cervix
High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs
The aim of the study is to explore the feasibility and safety of High Intensity Interval Training on a stationary bike for patients with lymphedema in the lower limbs and the role of compression garments during exercise.
- Conditions
- Lymphedema of Leg, Cancer of Cervix, Cancer, Ovarian, Cancer, Endometrial
- Trial name
- NCT03653819
- Testing
- First exercise session + compression, First exercise session - compression
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Herlev and Gentofte Hospital
Melanoma
Study of PI-88 in Patients With Advanced Melanoma
The purpose of this study is to determine whether PI-88 is safe and effective in the treatment of advanced melanoma.
- Trial name
- NCT00068172
- Testing
- PI-88
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Cellxpert Biotechnology Corp.
Medulloblastoma
Interest of a Dose Decrease for Radiotherapy Associated With Chemotherapy for Treatment of Standard Risk Adult Medulloblastomas
Adult medulloblastoma is a rare tumour. The "standard risk " group (complete surgery or residual tumour lower than 1,5 cm2, absence of malignant cells in the cerebrospinal fluid, absence of metastasis, absence of MYC…
- Trial name
- RSMA2010 (NCT01857453)
- Testing
- carboplatine, Etoposide, radiation therapy
- Where
- 20 sites in France
- Volunteers
- 97 people
- Sponsor
- Central Hospital, Nancy, France
Gastrointestinal Cancer, Colorectal Cancer
Assessment of a Serious Illness Conversation Guide (SICG) in Advanced Gastro-Intestinal Cancers
The purpose of the study is to determine whether standardized implementation of a scripted template for discussing important issues that arise near the end of life improves the care of those who have advanced cancer.
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Pancreatic Adenocarcinoma, Gastric Cancer
- Trial name
- NCT04077372
- Testing
- Serious Illness Conversation Guide (SICG), Quality of Life (QOL) survey
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Stage III/IV Melanoma
Tavo and Pembrolizumab in Patients With Stage III/IV Melanoma Progressing on Either Pembrolizumab or Nivolumab Treatment
Keynote 695 is Phase 2 study of intratumoral tavokinogene telseplasmid (tavo; pIL-12) Electroporation (EP) plus IV Pembrolizumab.
- Trial name
- Keynote-695 (NCT03132675)
- Testing
- tavokinogene telseplasmid, Pembrolizumab, ImmunoPulse
- Where
- 33 sites in United States, Australia and 3 more
- Volunteers
- 143 people
- Sponsor
- OncoSec Medical Incorporated
Vestibular Schwannoma
Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study
The effect of Gamma knife radiosurgery (GKRS) on hearing loss, in patients with vestibular schwannoma (VS) and preserved hearing is still unclear.
- Trial name
- NCT01938677
- Testing
- Initial Gamma knife radiosurgery
- Where
- Sweden
- Volunteers
- 67 people
- Sponsor
- Karolinska Institutet
Glioblastoma Multiforme, Glioblastoma
VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM
This is an adaptive design, randomized controlled, Phase 3 clinical trial in patients with glioblastoma multiforme (GBM) or gliosarcoma (GS), previously treated with surgery (if appropriate), standard of care chemo-radiation with…
- Conditions
- Glioblastoma Multiforme, Glioblastoma, Glioma, GBM
- Trial name
- STAR-3 (NCT03149575)
- Testing
- VAL-083, Dianhydrogalactitol, Physician's Choice of Salvage Therapy - temozolomide, Physician's Choice of Salvage Therapy - lomustine
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- DelMar Pharmaceuticals, Inc.
Glioma, Malignant
Glioma: Biomolecular Aspects
Main limitations in Glioma studies are due to the wide heterogeneity and genetic instability of the tumor and to the fact that the molecular informations are static, i.e. obtained on the tumor at its onset.
- Trial name
- GLIOMA (NCT05806619)
- Testing
- histopathological analysis; morphological and non-morphological magnetic resonance
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Regina Elena Cancer Institute
Neuroblastoma
Use of Virtual Reality for Surgical Planning in Neuroblastoma
Neuroblastoma is one of the most common extracranial solid tumors in children. It originates from cells of the neural crest, and can be located at the adrenal level, or in the sympathetic chains from the neck to the pelvis.
- Trial name
- VRNB (NCT05781919)
- Testing
- Immersive virtual reality imaging, Gold standard imaging
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Hospital Sant Joan de Deu
Pheochromocytoma, Paraganglioma
Correlation Between Preoperative Images of PPGL and Intraoperative Hemodynamics
This is a retrospective observational cohort study involving patients with suspected PPGLs who underwent 131I-MIBG scanning and surgical treatment between January 2020 and April 2023.
- Trial name
- NCT06669481
- Testing
- Semiquantitative 131I-MIBG Scintigraphy Assessment
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Peking Union Medical College Hospital
Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma
Exercise to Boost Response to Checkpoint Blockade Immunotherapy
The purpose of this pilot study will be to provide i) information on feasibility implementing an exercise intervention trial among patients with cutaneous cancers, including melanoma, squamous cell carcinoma (cuSCC), and Merkel…
- Conditions
- Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma
- Trial name
- EX-BOOST (NCT06008977)
- Testing
- Exercise Test
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- AdventHealth Translational Research Institute
Neuroendocrine Carcinoma
68Ga-DOTATATE PET-CT for Diagnosis of Neuroendocrine Tumors (NETs)
To evaluate the concordance and discordance between results of 68Ga-DOTATATE PET-CT scan and OctreoScan ® which is considered standard of care diagnostic test for neuroendocrine cancers and other imaging modalities like CT…
- Trial name
- NCT01879657
- Testing
- 68Ga-DOTATATE, PET/CT, 111In-pentetreotide OctreoScan
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Radio Isotope Therapy of America
Oncology, Neuroendocrine Carcinoma
Second-line Therapy for Patients With Progressive Poorly Differentiated Extra-pulmonary Neuroendocrine Carcinoma
There is currently no standard treatment beyond first-line etoposide/platinum-based chemotherapy in patients with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma.
- Trial name
- NET02 (NCT03837977)
- Testing
- Liposomal Irinotecan, Fluorouracil, Folinic Acid
- Where
- 4 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- The Christie NHS Foundation Trust
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.