Clinical trials: Emergencies
Pyelonephritis Acute
Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis
This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD).
- Trial name
- NCT06127160
- Testing
- Cephalexin
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brett A Faine
Pain Management
IBUPAP Study for Pain Management in Children
Current literature supports ibuprofen and APAP are the most commonly used analgesics in the pediatric ED for acute traumatic/non-traumatic pain.
- Trial name
- NCT03088800
- Testing
- Ibuprofen, APAP
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Antonios Likourezos
Alcohol Consumption
Pilot Study of a Computer-Based Intervention for Alcohol Misuse in the Emergency Department
Alcohol misuse amongst youth is a significant clinical and public health problem. The Emergency Department (ED) is an important setting for the treatment of alcohol-related problems as it is often the first point of contact…
- Trial name
- NCT01146665
- Testing
- Computer-based PAF
- Where
- 3 sites in Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Alberta
COVID-19
Hyperbaric Oxygen for COVID-19 Patients
Hyperbaric oxygen therapy (HBOT) treatment will be provided to patients as an adjunct to standard therapy for a cohort of 40 COVID19-positive patients with respiratory distress at NYU Winthrop Hospital.
- Trial name
- NCT04332081
- Testing
- hyperbaric oxygen therapy (HBOT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- NYU Langone Health
Diabetic Ketoacidosis
Use of Insulin Glargine to Treat Diabetic Ketoacidosis
The purpose of this study is to determine the effects of the addition of insulin glargine during the early phase of moderate to severe Diabetic Ketoacidosis (DKA) in children.
- Trial name
- NCT00179127
- Testing
- glargine, saline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Nausea
Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED
The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population.
- Trial name
- NCT00655642
- Testing
- Ondansetron, Metoclopramide, Promethazine
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Vanderbilt University
Diabetes Mellitus
Glycemic Optimization On Discharge From the Emergency Room
Continuous glucose monitors can help people with diabetes avoid blood sugar levels that are either dangerously high or low. This study evaluates whether continuous glucose monitoring after discharge from the emergency room can…
- Trial name
- GOOD-ER (NCT05197829)
- Testing
- Continuous Glucose Monitoring, Care Coordination
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mark O'Connor
Asthma
Timely Intravenous Magnesium for Asthma in Children
Many children currently being hospitalized with severe asthma could potentially avoid hospitalization and be sent home if their treatment in the emergency department was more effective.
- Trial name
- IMPACT-ED (NCT05166811)
- Testing
- Magnesium Sulfate, Heptahydrate, 0.9% saline
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Utah
Pneumonia
A Randomized Controlled Trial of Lung Ultrasound Compared to Chest X-ray for Diagnosing Pneumonia in the Emergency Department
The primary objective of this study is to determine if lung ultrasound (LUS) can replace chest x-ray (CXR) when evaluating patients with possible pneumonia.
- Trial name
- NCT01654887
- Testing
- Lung Ultrasound, Chest X-Ray
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Migraine
Trial of Comprehensive Migraine Intervention
Despite the fact that more than 10% of Americans suffer from migraine, this headache disorder is often not diagnosed and not appropriately treated.
- Trial name
- NCT01071317
- Testing
- Naproxen, Sumatriptan, Migraine education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Ovulation, Luteal Development
The Effect of a Non-hormonal Cox-2 Inhibitor (Celebrex) on Ovulation
The purpose of this study is to assess the effect that Celebrex (a COX-2 inhibitor and non-steroidal anti-inflammatory drug) has on ovulation.
- Trial name
- NCT01129245
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mechanical Ventilation, Ventilator-associated Conditions
ED Lung Protective Ventilation to Reduce Complications
Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS).
- Conditions
- Mechanical Ventilation, Ventilator-associated Conditions, ARDS
- Trial name
- NCT02543554
- Testing
- lung protective ventilation
- Where
- United States
- Volunteers
- 1,705 people
- Sponsor
- Washington University School of Medicine
Obesity
Effectiveness of Orally Dosed Emergency Contraception in Obese Women - LNG
Obese women are significantly more likely than their normal BMI counterparts to experience failure of orally-dosed emergency contraceptives.
- Trial name
- EC-Obesity (NCT02863445)
- Testing
- Levonorgestrel-based emergency contraception 1.5 mg, Levonorgestrel-based emergency contraception 3.0mg
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Carbon Monoxide Poisoning, Anemia
Utility of Non-invasive Carboxyhemoglobin and Total Hemoglobin Measurement in the Emergency Department
The purpose of this study is to determine the clinical utility of triage screening for anemia and carbon monoxide poisoning (COP) in the ED setting.This is a prospective, nonrandomized, multi-center study of the performance of…
- Trial name
- NCT03017742
- Testing
- Pulse Oximeter
- Where
- Turkey (Türkiye)
- Volunteers
- 813 people
- Sponsor
- Masimo Corporation
Acute Bronchiolitis
Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis
This is a randomized, double-blind, controlled trial in the Pediatric Emergency Department. The primary objective is to determine whether nebulized 3% hypertonic saline is more effective than nebulized 0.9% saline in the…
- Trial name
- NCT02029040
- Testing
- 3% Hypertonic Saline, 0.9 % normal saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Texas Southwestern Medical Center
Benign Paroxysmal Positional Vertigo
Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients
Benign Paroxysmal Positional Vertigo (BPPV) is a common complaint of emergency department patients. The importance of early diagnosis and treatment can lead to a much improved quality of life for patients afflicted by this…
- Trial name
- NCT00641797
- Testing
- Meclizine, Epley Maneuver, Lorazepam
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Lehigh Valley Hospital
Sepsis, Severe Sepsis
Protocolized Care for Early Septic Shock
The ProCESS study is large, 5-year, multicenter study of alternative resuscitation strategies for septic shock. The study hypothesizes that there are "golden hours" in the initial management of septic shock where prompt…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- ProCESS (NCT00510835)
- Testing
- Early Goal Directed Therapy (EGDT), Protocolized Standard Care (PSC), Usual Care (UC)
- Where
- 31 sites in United States
- Volunteers
- 1,351 people
- Sponsor
- University of Pittsburgh
Triage
Triaging and Referring in Adjacent General and Emergency Departments
Introduction: Patients who might also go to the general practitioner (GP) frequently consult emergency departments (ED). This leads to additional costs for both government and patient and a high workload for emergency physicians…
- Trial name
- TRIAGE (NCT03793972)
- Testing
- Triage with referral to primary care, Usual care
- Where
- 2 sites in Belgium
- Volunteers
- 8,158 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Hip Fractures, Analgesia
Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients
It is well-established that hip fractures impose a significant medical, socioeconomic, and financial burden. In the elderly population, the associated mortality and morbidity are particularly pronounced: within one year following…
- Conditions
- Hip Fractures, Analgesia, Femoral Nerve
- Trial name
- NCT06862154
- Testing
- IV Analgesia- Fentanyl, Femoral Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Marmara University
Intubation
Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Emergency intubation of patients in intensive care is a high-risk endeavour. For many decades, succinylcholine has been the neuromuscular blocking agent of choice.
- Trial name
- NCT00355368
- Testing
- Succinylcholine, Rocuronium
- Where
- Switzerland
- Volunteers
- 420 people
- Sponsor
- University Hospital, Basel, Switzerland