Clinical trials: Emergency Airway Management
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Tube Size Randomized Trial During Emergency Tracheal Intubation
The BREATHE trial is a parallel-group, pragmatic, randomized clinical trial comparing the effectiveness of smaller versus larger endotracheal tubes for mechanical ventilation of critically ill adults at 7 geographically diverse…
- Trial name
- BREATHE (NCT06939361)
- Testing
- Smaller endotracheal tube, Larger endotracheal tube
- Where
- 7 sites in United States
- Volunteers
- 3,180 people
- Sponsor
- Vanderbilt University Medical Center
Emergency Medicine, Airway Management
Pre-hospital Advanced Airway Management Studying Expedited Routines
In the Scandinavian and Swiss HEMS critical care teams, the prehospital tracheal intubations (TI) are performed by airway experts with high success rates and low rates of complications.
- Conditions
- Emergency Medicine, Airway Management, Intubation
- Trial name
- PHASTER (NCT04206566)
- Where
- 2 sites in Sweden
- Volunteers
- 430 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest
Effects of Laryngeal Tube Ventilation on no Flow Time During Out of Hospital Cardiac Arrest
International recommendations stress on the importance of no flow time reduction in cardiac arrest management. In fact, no flow time is an independent factor of morbidity and mortality.
- Trial name
- FLOWERS (NCT01295749)
- Testing
- laryngeal tube ventilation and continuous chest compression
- Where
- 2 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble
Trauma, Cardiac Arrest
Airway Management Study in Physician Manned Helicopter Emergency Medical Services
An international airway management expert group has recently developed an Utstein-style template for uniform reporting of data from prehospital advanced airway management.
- Conditions
- Trauma, Cardiac Arrest, Emergencies
- Trial name
- AIRPORT (NCT01502111)
- Where
- Norway
- Volunteers
- 2,333 people
- Sponsor
- Norwegian Air Ambulance Foundation
Endotracheal Intubation
Augmented Reality Smart Glasses Versus Video Laryngoscopy During Ambulance Transport
This randomized crossover simulation study evaluated the performance of augmented reality (AR) smart glasses compared with conventional video laryngoscopy (VL) for endotracheal intubation under simulated prehospital ambulance…
- Trial name
- AR-AMBULANCE (NCT07865663)
- Testing
- Augmented Reality-Assisted Laryngoscopy, Video Laryngoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ONUR KARAKAYALI
Telemedicine, Intubation; Difficult or Failed
Teleguidance-facilitated Airway Management
The advent of telemedicine has introduced teleguidance as a promising support to enhance endotracheal intubation skills among inexperienced operators.
- Conditions
- Telemedicine, Intubation; Difficult or Failed, Emergencies
- Trial name
- NCT06497725
- Testing
- Teleguidance-facilitated Airway Management
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Acute Respiratory Failure
Examination of Personalized SpO2 Targets
Mechanical ventilation involves titrating the fraction of inspired oxygen to maintain arterial oxygen saturation (SpO2). The SpO2 target that results in the best outcomes for critically ill adults has historically been unknown.
- Trial name
- EXPRESS (NCT07536984)
- Testing
- Personalized SpO2 Target, Usual Care
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Vanderbilt University Medical Center
Cardiac Arrest
Laryngeal Tube vs Laryngeal Mask Airway
Introduction: The laryngeal mask airway (LMA) is used as the primary airway by paramedics in Singapore Civil Defense Force's Emergency Ambulance Service (SCDF's EAS) in the management of out-of-hospital cardiac arrest, because…
- Trial name
- NCT02607644
- Testing
- Laryngeal Mask Airway (LMA), Laryngeal Tube (LT)
- Where
- Singapore
- Volunteers
- 965 people
- Sponsor
- Singapore General Hospital
Airway Management, Endotracheal Intubation
Novel Integrated Tube-Bougie Prototype for Endotracheal Intubation in Airway Simulation
Endotracheal intubation is a critical airway management procedure that frequently requires adjunctive devices, such as stylets or elastic bougies, to facilitate successful tube placement.
- Conditions
- Airway Management, Endotracheal Intubation, Difficult Airway
- Trial name
- ITBP (NCT07747922)
- Testing
- EPATS (Integrated Tube-Bougie Prototype), Standard gum elastic bougie, Standard stylet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huseyin Cahit Halhalli, MD
Intubation
Biphasic Ventilation Airway Management Clinical Trial
Investigators intend to determine if the use of Biphasic Cuirass Ventilation (BCV) improves patient safety (avoiding hypoxia) during emergency rapid sequence intubation .
- Trial name
- BVAM (NCT03042598)
- Testing
- Biphasic Cuirass Ventilation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University Medical Center of Southern Nevada
Endotracheal Intubation
Retrospective Study of Airway Management in Dutch ED's
Describing characteristics of the practice of airway management in Dutch emergency departments, including information about patient demographics, indications, performer characteristics, equipment and medication used and…
- Trial name
- NCT06374030
- Testing
- Endotracheal intubation
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Frisius Medisch Centrum
Airway Management, Tracheal Intubation
Taiwan ED Airway Quality Surveillance Registry (TEAR)
This prospective, multicenter observational registry systematically captures all emergency department tracheal intubations across participating hospitals in Taiwan.
- Conditions
- Airway Management, Tracheal Intubation, Emergency Department, Peri-intubation Adverse Events
- Trial name
- NCT07574450
- Where
- Taiwan
- Volunteers
- 1,200 people
- Sponsor
- Chang Gung Memorial Hospital
Endotracheal Intubation, Endotracheal Tube Placement
Bedside Ultrasound for Confirmation of Endotracheal Tube Placement in the Emergency Department
This prospective observational study evaluated the role of bedside ultrasound in confirming endotracheal tube placement in adult patients who underwent endotracheal intubation in the emergency department.
- Conditions
- Endotracheal Intubation, Endotracheal Tube Placement, Airway Management, Ultrasonographic
- Trial name
- NCT07669259
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Antalya Health Sciences University
Pulmonary Aspiration of Gastric Contents, Emergency Surgery
Gastric Ultrasound for Airway Management in Emergency Patients
This prospective observational cohort study evaluates the association between gastric residual content and volume, assessed by point-of-care gastric ultrasound (PoCUS), and the choice of airway management technique (Rapid…
- Conditions
- Pulmonary Aspiration of Gastric Contents, Emergency Surgery, Gastric Residual Volume, Airway Management
- Trial name
- NCT07640165
- Testing
- Preoperative Gastric Point-of-Care Ultrasound (PoCUS)
- Where
- Indonesia
- Volunteers
- 43 people
- Sponsor
- Universitas Indonesia
Prehospital Airway Management in Patients With Cardiac Arrest
A RCT on Supraglottic Airway Versus Endotracheal Intubation in OHCA
In this 3-year successive research plan, investigators will conduct a prehospital randomized controlled trial to address the following question: In adult patients with non-traumatic cause of out-of-hospital cardiac arrest…
- Trial name
- SAVE (NCT02967952)
- Testing
- supraglottic airway (SGA) V.S. endotracheal intubation (ETI)
- Volunteers
- 852 people
- Sponsor
- National Taiwan University Hospital
Airway Management, Tracheal Intubation
Evaluation of SaCoVLM™ Video Laryngeal Mask for Airway Management in Military Medics
A prospective, two-phase interventional study evaluating the performance, safety, and usability of the SaCoVLM™ video laryngeal mask airway for airway management by military medics with limited intubation experience.
- Conditions
- Airway Management, Tracheal Intubation, Anesthesia
- Trial name
- SAVER (NCT07249983)
- Testing
- SaCoVLM™ Video Laryngeal Mask
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Intubation in Intensive Care Units
Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
The goal of this clinical trial is to learn if it is feaseble to conduct a superiority trial comparing two methods for endotracheal intubation in critically ill patients.
- Trial name
- DARSITUBE (NCT06940219)
- Testing
- Delayed Sequence Induction, Modified Rapid Sequence Induction
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Leipzig University Medical Center
Out-Of-Hospital Cardiac Arrest
First Responder Airway & Compression Rate Trial
The First responder Airway \& Compression rate Trial (FACT) Study will address basic life support (BLS) treatments administered by Emergency Medical Services (EMS) first responders to patients who suffer a sudden circulatory…
- Trial name
- FACT (NCT05969028)
- Testing
- igel, Compression Rate
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- University of Washington